714932-54-4
714932-54-4
Chemical Structure
NCGC00063279
- CAS No.: 714932-54-4
- Formula:C18H13N3O3
- Molecular Weight:319.31
InChIKey: BRKAIFLXINCNLS-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C=C1C3=NOC(C4=CC=CC=C4)=N3)C=C(OC)C=C2
Biological Activity: NCGC00063279 is a reversible Werner Syndrome Helicase-Nuclease (WRN) helicase inhibitor with modest selectivity over BLM and FANCJ helicases, and does not inhibit WRN exonuclease activity at active concentrations. NCGC00063279 inhibits Hematopoietic Protein Tyrosine Phosphatase (HePTP) and reduces proliferation of cancer cells. NCGC00063279 can be used for the research of osteosarcoma[1].
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NCGC00063279 | NCGC00063279 is a reversible Werner Syndrome Helicase-Nuclease (WRN) helicase inhibitor with modest selectivity over BLM and FANCJ helicases, and does not inhibit WRN exonuclease activity at active concentrations. NCGC00063279 inhibits Hematopoietic Protein Tyrosine Phosphatase (HePTP) and reduces proliferation of cancer cells. NCGC00063279 can be used for the research of osteosarcoma. | |||||||||||||||||||||
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References
Keywords
