human+insulin

By Targets:	Biochemical Assay Reagents (1) IGF-1R (2) Insulin Receptor (7) mRNA (9) NF-κB (2) p38 MAPK (2)
By Research Areas:	Infection (2) Inflammation/Immunology (3) Metabolic Disease (18)
Oligonucleotides:	mRNA (9)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2093

S961 5+ Cited Publications	Insulin Receptor	Metabolic Disease
S961 is an high-affinity and selective insulin receptor (IR) antagonist with IC₅₀s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively .

HY-P2358

PSMα3	NF-κB p38 MAPK	Infection Inflammation/Immunology
PSMα3 is an inhibitor of NF-κB p65 and p38 MAPK. PSMα3 forms membrane pores and binds to residues of human insulin B chain to inhibit insulin aggregation. PSMα3 forms α-type amyloid-like fibrils to exert cytotoxic effects, and acts as a functional amyloid virulence determinant of Staphylococcus aureus. PSMα3 is applicable to research related to spondyloarthritis, rheumatoid arthritis, insulin-derived amyloidosis, and Staphylococcus aureus infection .

HY-P2093B

S961 acetate 5+ Cited Publications	Insulin Receptor	Metabolic Disease
S961 acetate is an high-affinity and selective insulin receptor (IR) antagonist with IC₅₀s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively .

HY-108905

Mecasermin Human IGF-I; FK 780	IGF-1R	Metabolic Disease
Mecasermin (Human IGF-I; FK 780) is a recombinant human insulin-like growth factor I (IGF-I). Mecasermin has the potential for the study of the growth failure of growth hormone (GH) insensitivity caused by GH receptor defects or GH-inhibiting antibodies .

HY-P99530

Valanafusp alfa AGT-181; HIRMAb-IDUA	Insulin Receptor	Metabolic Disease
Valanafusp alfa (AGT-181) is a chimeric monoclonal antibody that fuses human α-L-iduronidase (IDUA) and targets the human insulin receptor (HIR). Valanafusp alfa has brain penetrating properties, making it useful for research on mucopolysaccharidosis type I (MPS I) .

HY-174655

Human IGF1 mRNA	mRNA	Metabolic Disease
Human IGF1 mRNA encodes the human insulin like growth factor 1 (IGF1) protein which is involved in mediating growth and development.

HY-109530

Insulin lispro	Insulin Receptor	Metabolic Disease
Insulin lispro is a recombinant human insulin analogue and is one of three rapid-acting insulin analogues available. Insulin lispro can be used for the research of hyperglycaemia in diabetes mellitus .

HY-101962

HNMPA	Insulin Receptor	Metabolic Disease
HNMPA is a membrane impermeable insulin receptor tyrosine kinase inhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the human insulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities

HY-P2093A

S961 TFA	Insulin Receptor	Metabolic Disease
S961 TFA is an high-affinity and selective insulin receptor (IR) antagonist with IC₅₀s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively .

HY-P991134

Elegrobart	IGF-1R	Inflammation/Immunology
Elegrobart is an immunoglobulin G1-κ monoclonal antibody targeting the human insulin-like growth factor 1 receptor (IGF1R). Elegrobart is promising for research of diseases associated with abnormal IGF1R signaling, especially thyroid eye disease .

HY-W337897

Tetradecyl-β-D-maltoside	Biochemical Assay Reagents	Metabolic Disease
Tetradecyl-β-D-maltoside is an absorption enhancer which can increase the nasal absorption of regular human insulin or the fast acting insulin analog lyspro-insulin .

HY-174652

Human IGFBP1 mRNA	mRNA	Metabolic Disease
Human IGFBP1 mRNA encodes the human insulin like growth factor binding protein 1 (IGFBP1) protein, a member of the insulin-like growth factor binding protein (IGFBP) family. IGFBP1 is important in cell migration and metabolism.

HY-174647

Human IGFBP6 mRNA	mRNA	Metabolic Disease
Human IGFBP6 mRNA encodes the human insulin like growth factor binding protein 6 (IGFBP6) protein. IGFBP6 probably involves in prolong the half-life of the IGFs and either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.

HY-174648

Human IGFBP5 mRNA	mRNA	Metabolic Disease
Human IGFBP5 mRNA encodes the human insulin like growth factor binding protein 5 (IGFBP5) protein. IGFBP5 probably involves in prolong the half-life of the IGFs and either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.

HY-174649

Human IGFBP4 mRNA	mRNA	Metabolic Disease
Human IGFBP4 mRNA encodes the human insulin like growth factor binding protein 4 (IGFBP4) protein, a member of the insulin-like growth factor binding protein (IGFBP) family. IGFBP4 can bind both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.

HY-174650

Human IGFBP3 mRNA	mRNA	Metabolic Disease
Human IGFBP3 mRNA encodes the human insulin like growth factor binding protein 3 (IGFBP3) protein, a member of the insulin-like growth factor binding protein (IGFBP) family. IGFBP3 can form a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors.

HY-P2358A

PSMα3 TFA	NF-κB p38 MAPK	Infection Inflammation/Immunology
PSMα3 TFA is an inhibitor of NF-κB p65 and p38 MAPK. PSMα3 TFA forms membrane pores and binds to residues of human insulin B chain to inhibit insulin aggregation. PSMα3 TFA forms α-type amyloid-like fibrils to exert cytotoxic effects, and acts as a functional amyloid virulence determinant of Staphylococcus aureus. PSMα3 TFA is applicable to research related to spondyloarthritis, rheumatoid arthritis, insulin-derived amyloidosis, and Staphylococcus aureus infection .

HY-174654

Human IGF1R mRNA	mRNA	Metabolic Disease
Human IGF1R mRNA encodes the human insulin like growth factor 1 receptor (IGF1R) protein. IGF1R plays a critical role in transformation events.

HY-174651

Human IGFBP2 mRNA	mRNA	Metabolic Disease
Human IGFBP2 mRNA encodes the human insulin like growth factor binding protein 2 (IGFBP2) protein, is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II).

HY-174653

Human IGF2 mRNA	mRNA	Metabolic Disease
Human IGF2 mRNA encodes the human insulin like growth factor 2 (IGF2) protein, a member of the insulin family of polypeptide growth factors. IGF2 plays a key role in regulating fetoplacental development and also involves in tissue differentiation.

HY-P992048

AGT-182 HIRMab; SHP-631; TAK-531	Insulin Receptor	Metabolic Disease
AGT-182 (HIRMab; SHP-631; TAK-531) is a brain-penetrating anti-human insulin receptor antibody and iduronate-2-sulfatase conjugation. AGT-182 can be used for the research of mucopolysaccharidosis type II (MPS II, Hunter syndrome) .

Cat. No.	Product Name	Type

HY-W337897

Tetradecyl-β-D-maltoside	Biochemical Assay Reagents
Tetradecyl-β-D-maltoside is an absorption enhancer which can increase the nasal absorption of regular human insulin or the fast acting insulin analog lyspro-insulin .

Cat. No.	Product Name	Target	Research Area

HY-P2093

S961 5+ Cited Publications	Insulin Receptor	Metabolic Disease
S961 is an high-affinity and selective insulin receptor (IR) antagonist with IC₅₀s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively .

HY-P2358

PSMα3	NF-κB p38 MAPK	Infection Inflammation/Immunology
PSMα3 is an inhibitor of NF-κB p65 and p38 MAPK. PSMα3 forms membrane pores and binds to residues of human insulin B chain to inhibit insulin aggregation. PSMα3 forms α-type amyloid-like fibrils to exert cytotoxic effects, and acts as a functional amyloid virulence determinant of Staphylococcus aureus. PSMα3 is applicable to research related to spondyloarthritis, rheumatoid arthritis, insulin-derived amyloidosis, and Staphylococcus aureus infection .

HY-P2093B

S961 acetate 5+ Cited Publications	Insulin Receptor	Metabolic Disease
S961 acetate is an high-affinity and selective insulin receptor (IR) antagonist with IC₅₀s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively .

HY-108905

Mecasermin Human IGF-I; FK 780	IGF-1R	Metabolic Disease
Mecasermin (Human IGF-I; FK 780) is a recombinant human insulin-like growth factor I (IGF-I). Mecasermin has the potential for the study of the growth failure of growth hormone (GH) insensitivity caused by GH receptor defects or GH-inhibiting antibodies .

HY-P2093A

S961 TFA	Insulin Receptor	Metabolic Disease
S961 TFA is an high-affinity and selective insulin receptor (IR) antagonist with IC₅₀s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively .

HY-P2358A

PSMα3 TFA	NF-κB p38 MAPK	Infection Inflammation/Immunology
PSMα3 TFA is an inhibitor of NF-κB p65 and p38 MAPK. PSMα3 TFA forms membrane pores and binds to residues of human insulin B chain to inhibit insulin aggregation. PSMα3 TFA forms α-type amyloid-like fibrils to exert cytotoxic effects, and acts as a functional amyloid virulence determinant of Staphylococcus aureus. PSMα3 TFA is applicable to research related to spondyloarthritis, rheumatoid arthritis, insulin-derived amyloidosis, and Staphylococcus aureus infection .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99530

Valanafusp alfa AGT-181; HIRMAb-IDUA	Insulin Receptor	Metabolic Disease
Valanafusp alfa (AGT-181) is a chimeric monoclonal antibody that fuses human α-L-iduronidase (IDUA) and targets the human insulin receptor (HIR). Valanafusp alfa has brain penetrating properties, making it useful for research on mucopolysaccharidosis type I (MPS I) .

HY-P991134

Elegrobart	IGF-1R	Inflammation/Immunology
Elegrobart is an immunoglobulin G1-κ monoclonal antibody targeting the human insulin-like growth factor 1 receptor (IGF1R). Elegrobart is promising for research of diseases associated with abnormal IGF1R signaling, especially thyroid eye disease .

HY-P992048

AGT-182 HIRMab; SHP-631; TAK-531	Insulin Receptor	Metabolic Disease
AGT-182 (HIRMab; SHP-631; TAK-531) is a brain-penetrating anti-human insulin receptor antibody and iduronate-2-sulfatase conjugation. AGT-182 can be used for the research of mucopolysaccharidosis type II (MPS II, Hunter syndrome) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P2358

PSMα3	Structural Classification Natural Products Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	NF-κB p38 MAPK
PSMα3 is an inhibitor of NF-κB p65 and p38 MAPK. PSMα3 forms membrane pores and binds to residues of human insulin B chain to inhibit insulin aggregation. PSMα3 forms α-type amyloid-like fibrils to exert cytotoxic effects, and acts as a functional amyloid virulence determinant of Staphylococcus aureus. PSMα3 is applicable to research related to spondyloarthritis, rheumatoid arthritis, insulin-derived amyloidosis, and Staphylococcus aureus infection .

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (1)
Application:	IHC-P (1) ICC/IF (2) IHC-F (1) WB (2) ELISA (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Polyclonal (1) Monoclonal (1) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81116

	IRS-1 Antibody IRS1_HUMAN; Insulin receptor substrate 1; IRS-1; IRS 1;	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	IRS-1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IRS-1.

HY-P81795

	Insulin Receptor Antibody (YA1540) CD220; HHF5; human insulin receptor; Insr; Insulin receptor subunit beta; IR 1; IR	WB, ICC/IF	Human, Rat
	Insulin Receptor Antibody (YA1540) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Insulin Receptor.

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Cat. No.	Product Name		Classification

HY-174655

Human IGF1 mRNA		mRNA
Human IGF1 mRNA encodes the human insulin like growth factor 1 (IGF1) protein which is involved in mediating growth and development.

HY-174652

Human IGFBP1 mRNA		mRNA
Human IGFBP1 mRNA encodes the human insulin like growth factor binding protein 1 (IGFBP1) protein, a member of the insulin-like growth factor binding protein (IGFBP) family. IGFBP1 is important in cell migration and metabolism.

HY-174647

Human IGFBP6 mRNA		mRNA
Human IGFBP6 mRNA encodes the human insulin like growth factor binding protein 6 (IGFBP6) protein. IGFBP6 probably involves in prolong the half-life of the IGFs and either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.

HY-174648

Human IGFBP5 mRNA		mRNA
Human IGFBP5 mRNA encodes the human insulin like growth factor binding protein 5 (IGFBP5) protein. IGFBP5 probably involves in prolong the half-life of the IGFs and either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.

HY-174649

Human IGFBP4 mRNA		mRNA
Human IGFBP4 mRNA encodes the human insulin like growth factor binding protein 4 (IGFBP4) protein, a member of the insulin-like growth factor binding protein (IGFBP) family. IGFBP4 can bind both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.

HY-174650

Human IGFBP3 mRNA		mRNA
Human IGFBP3 mRNA encodes the human insulin like growth factor binding protein 3 (IGFBP3) protein, a member of the insulin-like growth factor binding protein (IGFBP) family. IGFBP3 can form a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors.

HY-174654

Human IGF1R mRNA		mRNA
Human IGF1R mRNA encodes the human insulin like growth factor 1 receptor (IGF1R) protein. IGF1R plays a critical role in transformation events.

HY-174651

Human IGFBP2 mRNA		mRNA
Human IGFBP2 mRNA encodes the human insulin like growth factor binding protein 2 (IGFBP2) protein, is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II).

HY-174653

Human IGF2 mRNA		mRNA
Human IGF2 mRNA encodes the human insulin like growth factor 2 (IGF2) protein, a member of the insulin family of polypeptide growth factors. IGF2 plays a key role in regulating fetoplacental development and also involves in tissue differentiation.

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Inhibitors & Agonists

Biochemical Assay Reagents

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human+insulin

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Biochemical Assay Reagents

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Oligonucleotides

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