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S961 TFA

9 Cited Publications
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Based on 9 publication(s) in Google Scholar

S961 TFA is an high-affinity and selective insulin receptor (IR) antagonist with IC50s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively.

For research use only. We do not sell to patients.

  • Formula: C211H295N55O71S2.xC2HF3O2
  • Molecular Weight:4802.12 (free acid)
  • Storage:

    Sealed storage, away from moisture and light.

    Powder   -80°C, 2 years , -20°C, 1 year

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

  • S961 TFA Chemical Structure
    S961 TFA Chemical Structure
  • Experimental Validation Results for S961 TFA
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Publications Citing Use of MedChemExpress (MCE) S961 TFA

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  • Bio/Physico-chemical Assay

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  • S961 TFA Chemical Structure
    S961 TFA Chemical Structure
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    S961 TFA purchased from MedChemExpress. Usage Cited in: Nature. 2026 Jun;654(8120):1065-1075. [Abstract]

    Customer Validation
     Panc02, a murine pancreatic cancer cell line was used as positive control for staining Insr. Mice were injected with Insr blocking chemical S961 (1 mg/kg; i.p.) during fasting/fed period. OCR and ECAR were measured of ex vivo CD8+ T cells purified from pool of respective group. OCR and ECAR associated parameters were calculated (right) (n = 3 wells). The results showed that blocking insulin receptors (using S961) did not show significant changes in vivo under fasting and full conditions, indicating that the insulin signaling pathway is not essential for the postprandial benefits observed in T cells.

  • S961 TFA