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Isoforms Recommended:	KLK2

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klk2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Kallikrein (1) Androgen Receptor (4) c-Myc (2) CD3 (2) Orphan Nuclear Receptor (2) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (5) Inflammation/Immunology (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Kallikrein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P991015

Pasritamig JNJ-78278343; KLCB-245	CD3	Cancer
Pasritamig (JNJ-78278343; KLCB-245) is a bispecific T-cell engager (BiTE) that targets the complex of human kallikrein *KLK2* and CD3 receptor. Pasritamig redirects the cytotoxicity of T cells to *KLK2*-expressing tumor cells and induces T cell-mediated lysis of *KLK2*-expressing prostate cancer cells. Administered via subcutaneous injection, subcutaneous infusion or intravenous infusion, Pasritamig exhibits antitumor activity against metastatic castration-resistant prostate cancer. Pasritamig has a safety profile with an extremely low incidence of cytokine release syndrome and can be safely administered in an outpatient setting. Pasritamig is applicable to the research of metastatic castration-resistant prostate cancer ^[2] .

HY-P990608

Alpitatug IMC 3C5; JNJ-69086420 antibody; Anti-klk2 Antibody (h11B6)	CD3	Inflammation/Immunology
Alpitatug (IMC 3C5) is a CHO-expressed human antibody that targets KLK2/Kallikrein 2. Alpitatug has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.3 kDa. The isotype control for Alpitatug can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-RS07380

KLK2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
KLK2 Human Pre-designed siRNA Set A contains three designed siRNAs for KLK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

KLK2 Human Pre-designed siRNA Set A KLK2 Human Pre-designed siRNA Set A

HY-181971

XY25028	Orphan Nuclear Receptor Androgen Receptor c-Myc	Cancer
XY25028 is an orally active LRH-1 inhibitor with an IC₅₀ of 0.30 μM. XY25028 inhibits the proliferation of androgen receptor (AR)-positive prostate cancer cells and suppresses the expression of AR target genes KLK2 and KLK3. XY25028 can be used in the research of castration-resistant prostate cancer .

HY-181970

XY25026	Orphan Nuclear Receptor Androgen Receptor c-Myc	Cancer
XY25026 is an orally active LRH-1 inhibitor with an IC₅₀ of 0.28 μM. XY25026 inhibits the proliferation of androgen receptor (AR)-positive prostate cancer cells, suppresses the expression of AR target genes KLK2 and KLK3, and inhibits tumor growth in xenograft models. XY25026 is applicable to the research of castration-resistant prostate cancer .

HY-183667

JNJ-pan-AR	Androgen Receptor Kallikrein	Cancer
JNJ-pan-AR is an orally active androgen receptor (AR) inhibitor with an IC₅₀ of 19 nM and a K_i of 8.4 nM against human wild-type AR. JNJ-pan-AR abolishes androgen-induced *KLK2* and *KLK3* mRNA expression and reduces androgen-dependent colony formation in prostate cancer cells. JNJ-pan-AR blocks AR nuclear translocation, inhibits PSA protein expression, and represses the growth of AR-dependent tumor cells and ARF877L-driven tumor xenografts. JNJ-pan-AR blocks transactivation and signaling of wild-type AR and various mutant AR variants. JNJ-pan-AR is applicable for research on castration-resistant prostate cancer ^[2].

HY-183287

Androgen receptor antagonist-14	Androgen Receptor	Cancer
Androgen receptor antagonist-14 (Compound S-94) is a selective antagonist of the T878A mutant androgen receptor (AR) with an IC₅₀ of 0.38 μM. Androgen receptor antagonist-14 selectively antagonizes the transcriptional activity of the AR ^T878A, AR ^F877L/T878A and AR ^H875Y/T878A mutant androgen receptors. Androgen receptor antagonist-14 exhibits anticancer activity against prostate cancer. Androgen receptor antagonist-14 can be used in the research of prostate cancer .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991015

Pasritamig JNJ-78278343; KLCB-245	CD3	Cancer
Pasritamig (JNJ-78278343; KLCB-245) is a bispecific T-cell engager (BiTE) that targets the complex of human kallikrein *KLK2* and CD3 receptor. Pasritamig redirects the cytotoxicity of T cells to *KLK2*-expressing tumor cells and induces T cell-mediated lysis of *KLK2*-expressing prostate cancer cells. Administered via subcutaneous injection, subcutaneous infusion or intravenous infusion, Pasritamig exhibits antitumor activity against metastatic castration-resistant prostate cancer. Pasritamig has a safety profile with an extremely low incidence of cytokine release syndrome and can be safely administered in an outpatient setting. Pasritamig is applicable to the research of metastatic castration-resistant prostate cancer ^[2] .

HY-P990608

Alpitatug IMC 3C5; JNJ-69086420 antibody; Anti-klk2 Antibody (h11B6)	CD3	Inflammation/Immunology
Alpitatug (IMC 3C5) is a CHO-expressed human antibody that targets KLK2/Kallikrein 2. Alpitatug has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.3 kDa. The isotype control for Alpitatug can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P704731

	Kallikrein-2 Protein, Human (Active, HEK293) rHuKallikrein 2/klk2; His; Kallikrein-2; Glandular Kallikrein-1; hGK-1; Tissue Kallikrein-2; klk2	Human	HEK293
	The Kallikrein-2 protein is a member of the glandular kallikrein family and is critical in the enzymatic process as it selectively cleaves the Met-Lys and Arg-Ser bonds in kininogen, thereby releasing Lys-bradykinin . This proteolytic activity contributes to the production of bradykinin, a bioactive peptide with multiple roles in regulating blood pressure, inflammation, and vascular permeability. Kallikrein-2 Protein, Human (Active, HEK293) is the recombinant human-derived Kallikrein-2 protein, expressed by HEK293, with tag free.

HY-P70317

	Kallikrein-2 Protein, Human (HEK293, His) rHuKallikrein 2/klk2, His; Kallikrein-2; Glandular Kallikrein-1; hGK-1; Tissue Kallikrein-2; klk2	Human	HEK293
	The Kallikrein-2 protein is a member of the glandular kallikrein family and is critical in the enzymatic process as it selectively cleaves the Met-Lys and Arg-Ser bonds in kininogen, thereby releasing Lys-bradykinin . This proteolytic activity contributes to the production of bradykinin, a bioactive peptide with multiple roles in regulating blood pressure, inflammation, and vascular permeability. Kallikrein-2 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-2 protein, expressed by HEK293 , with C-6*His labeled tag.

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Host:	Mouse (4) Rabbit (1)
Reactivity:	Human (5) Rat (1) Mouse (1)
Application:	IHC-P (4) ICC/IF (3) WB (1) FC (4) ELISA (4)
Isotype:	IgG (1) IgG1 (4)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (1) Monoclonal Antibody (2) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82984

	Kallikrein 2 Antibody (YA2729) hK2; hGK-1; klk2A2	WB, ICC/IF	Human, Mouse, Rat
	Kallikrein 2 Antibody (YA2729) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Kallikrein 2.

HY-P84164

	Kallikrein 2 Antibody (YA3861) hK2; hGK-1; klk2A2	IHC-P, ICC/IF, FC, ELISA	Human
	Kallikrein 2 Antibody (YA3861) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Kallikrein 2.

HY-P83986

	Prostate Specific Antigen Antibody (YA3683) APS; PSA; hK3; klk2A1; klk3	IHC-P, FC, ELISA	Human
	Prostate Specific Antigen Antibody (YA3683) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Prostate Specific Antigen.

HY-P84164A

	Kallikrein 2 Antibody (YA3861)(PBS only) hK2; hGK-1; klk2A2	IHC-P, ICC/IF, FC, ELISA	Human
	Kallikrein 2 Antibody (YA3861) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Kallikrein 2.

HY-P83986A

	Prostate Specific Antigen Antibody (YA3683)(PBS only) APS; PSA; hK3; klk2A1; klk3	IHC-P, FC, ELISA	Human
	Prostate Specific Antigen Antibody (YA3683) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Prostate Specific Antigen.

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KLK2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
KLK2 Human Pre-designed siRNA Set A contains three designed siRNAs for KLK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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