2. Vitamin D Related/Nuclear Receptor Apoptosis
  3. Orphan Nuclear Receptor Androgen Receptor c-Myc
  4. XY25026

XY25026 is an orally active LRH-1 inhibitor with an IC50 of 0.28 μM. XY25026 inhibits the proliferation of androgen receptor (AR)-positive prostate cancer cells, suppresses the expression of AR target genes KLK2 and KLK3, and inhibits tumor growth in xenograft models. XY25026 is applicable to the research of castration-resistant prostate cancer.

For research use only. We do not sell to patients.

XY25026

XY25026 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

XY25026 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

XY25026 is an orally active LRH-1 inhibitor with an IC50 of 0.28 μM. XY25026 inhibits the proliferation of androgen receptor (AR)-positive prostate cancer cells, suppresses the expression of AR target genes KLK2 and KLK3, and inhibits tumor growth in xenograft models. XY25026 is applicable to the research of castration-resistant prostate cancer[1].

In Vitro

XY25026 (1 h) potently inhibits the interaction between human LRH-1 LBD and SRC1 coactivator peptide in a cell-free AlphaScreen assay with an IC50 of 280 nM[1].
XY25026 (96 h) inhibits proliferation of 22Rv1, C4-2B, and LNCaP human prostate cancer cell lines with IC50 values of 13.29 μM, 14.56 μM, and 15.89 μM, respectively[1].
XY25026 (0-40 μM; 48 h) suppresses expression of AR target genes KLK2 and KLK3, and the oncogenic protein c-Myc, in 22Rv1 human prostate cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

XY25026 Related Antibodies

Real Time qPCR[1]

Cell Line: 22Rv1 cells
Concentration: 0, 10, 20 and 40 μM
Incubation Time: 48 h
Result: Suppressed expression of AR target genes KLK2 and KLK3.

Western Blot Analysis[1]

Cell Line: 22Rv1 cells
Concentration: 0, 2.5, 5, 10, 20 and 40 μM
Incubation Time: 48 h
Result: Inhibited the expression of c-Myc.
Parmacokinetics
Species Dose Route Cmax Tmax AUC0-t AUC0-∞ T1/2 CL F
Rat[1] 1 mg/kg i.v. 578 ng/mL 0.083 h 343 ng·h/mL 346 ng·h/mL 1.28 h 3071 mL/h/kg /
Rat[1] 5 mg/kg p.o. 37.1 ng/mL 0.833 h 94.6 ng·h/mL 98.5 ng·h/mL 1.63 h / 5.69 %
In Vivo

XY25026 (50-100 mg/kg; p.o.; once daily; 16 days) achieves tumor growth inhibition rates of 31.5% and 44.6%, respectively, in a 22Rv1 castration-resistant prostate cancer xenograft model with no detectable systemic toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c-Nude (male, 5 weeks old)[1]
Dosage: 50 mg/kg; 100 mg/kg
Administration: p.o.; once daily; 16 days
Result: Achieved a tumor growth inhibition (TGI) rate of 31.5%.
Achieved a tumor growth inhibition (TGI) rate of 44.6%.
Showed no significant body weight changes (a marker of systemic toxicity) throughout the study.
Molecular Weight

470.60

Formula

C30H34N2O3
SMILES

NC1=CC=C(N(CC2=CC=CC=C2)C=C3C4=CC=C(OCCCCC(OC(C)(C)C)=O)C=C4)C3=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

XY25026 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XY25026XY 25026XY-25026Orphan Nuclear ReceptorAndrogen Receptorc-MycMyc22Rv1C4-2Bxenograft modelKLK2micecastration-resistant prostate cancerLRH-1KLK3androgen receptor-positive prostate cancer cellsandrogen receptorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
XY25026
Cat. No.:
HY-181970
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.