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Alpitatug

(別名: IMC 3C5; JNJ-69086420 antibody; Anti-KLK2 Antibody (h11B6))
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Based on 1 Customer Validation

Alpitatug (IMC 3C5) is a fully human monoclonal antibody and also a VEGFR3 inhibitor. Alpitatug blocks renal lymphangiogenesis, prevents the formation of tubulointerstitial lymphatic vessels, and reduces the number of lymphatic vessels in rats. Alpitatug does not alter the proteinuria level, inflammatory cell infiltration, fibrosis markers or renal function parameters in proteinuric rats. Alpitatug can be used in research related to proteinuric nephropathy and advanced solid tumors.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度 : 99.13%
  • CAS 番号: 2921676-05-1
  • 分子量:145.30 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Alpitatug
  • Experimental Validation Results for Alpitatug
  • Experimental Validation Results for Alpitatug
  • Alpitatug Chemical Structure
    Alpitatug 構造式
CAS 番号: 2921676-05-1
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    IgG1-kappa

  • 1/16

    Immobilized Human Kallikrein can bind Alpitatug. The EC50 for this effect is 227.9 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 HT-29 cells with Alpitatug (HY-P990608, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Alpitatug Chemical Structure
    1/16
  • Alpitatug
  • Immobilized Human Kallikrein can bind Alpitatug. The EC50 for this effect is 227.9 ng/mL.
  • Flow cytometric analysis of 1.5×106 HT-29 cells with Alpitatug (HY-P990608, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • IgG1-kappa