Alpitatug
Based on 1 Customer Validation
Alpitatug (JNJ-69086420 antibody) is a humanized monoclonal antibody against KLK2. When radiolabeled, it forms [111In]-DOTA-Alpitatug, which can be used in research on metastatic castration-resistant prostate cancer.
For research use only. We do not sell to patients.
- Purity : 99.13%
- CAS No.: 2921676-05-1
- Molecular Weight:145.30 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
All Radionuclide-Drug Conjugates (RDCs) Isoforms
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Biological Activity
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
RDC Antibody |
KLK2 |
Gene ID
Accession
Conjugated
Unconjugated
Reconstitution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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IgG1-kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized Human Kallikrein can bind Alpitatug. The EC50 for this effect is 227.9 ng/mL. -
Flow cytometric analysis of 1.5×106 HT-29 cells with Alpitatug (HY-P990608, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 2921676-05-1
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Appearance Liquid
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Molecular Weight 145.30 kDa
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Color Colorless to light yellow
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Synonyms
JNJ-69086420 antibody; Anti-KLK2 Antibody (h11B6)
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- Alpitatug
- 2921676-05-1
- JNJ-69086420 antibody
- Anti-KLK2 Antibody (h11B6)
- Radionuclide-Drug Conjugates (RDCs)
- Kallikrein
- KLK
- Kallikrein-related peptidase
- rats
- advanced solid tumors
- angiogenesis
- VEGFR3
- proteinuric nephropathy
- tumor lymphangiogenesis
- male Wistar rats
- renal lymphangiogenesis
- tubulointerstitial lymphatic vessel
- Inhibitor
- inhibitor
- inhibit