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loxl2 inhibitor

" in MedChemExpress (MCE) Product Catalog:

標的別:	Apoptosis (2) Cytochrome P450 (1) FAK (1) Guanylate Cyclase (1) HIV Protease (2) Lipoxygenase (1) Lysyl Oxidase (3) Monoamine Oxidase (16) Reactive Oxygen Species (ROS) (1) Reference Standards (3)
研究分野別:	Cancer (6) Cardiovascular Disease (5) Infection (2) Inflammation/Immunology (10) Metabolic Disease (2)

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天然物

製品番号	製品名	Target	研究分野	構造式

HY-127009

Levoleucovorin Levofolinic acid; Levofolene	Lysyl Oxidase Apoptosis	Metabolic Disease Cancer
Levoleucovorin (Levofolinic acid; Levofolene) is the pharmacologically and orally active levoisomer of Folinic acid (HY-17556), a synthetic folate analogue. Levoleucovorin can inhibit *LOXL2* with an IC₅₀ of 68.81 μM. Levoleucovorin can inhibit cancer cells proliferation, migration and induce apoptosis. Levoleucovorin can be used as a rescue agent for high-dose Methotrexate (HY-14519). Levoleucovorin can reduce the frequency of embryonic malformations. Levoleucovorin can be used for the research of can and endocrinology, such as breast cancer and osteosarcoma .

HY-101771A

(2-Chloropyridin-4-yl)methanamine hydrochloride Maximum Cited Publications 9 Publications Verification	Monoamine Oxidase	Cardiovascular Disease Inflammation/Immunology
(2-Chloropyridin-4-yl)methanamine hydrochloride is a selective *LOXL2* inhibitor with an IC₅₀ of 126 nM.

HY-N0554

Escin IA 1 Publications Verification	HIV Protease Monoamine Oxidase	Infection Inflammation/Immunology Cancer
Escin IA is an oral *LOXL2* inhibitor and EMT inhibitor, with selectivity for *LOXL2*-expressing cells. Escin IA suppresses invasion, migration, and metastasis of breast cancer cells, and acts as the primary anti-TNBC metastasis constituent of Aesculus chinensis Bunge fruit saponin fraction. Escin IA can be used for the research of triple-negative breast cancer, acute inflammation, and ethanol-induced gastric mucosal lesions .

HY-107422

Lenumlostat 3 Publications Verification PAT-1251; GB2064	Monoamine Oxidase	Inflammation/Immunology
PAT-1251 is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC₅₀s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC₅₀s, 0.10, 0.12, and 0.16 μM, respectively); PAT-1251 is used in the research of fibrotic diseases .

HY-130242

PXS-5120A	Monoamine Oxidase	Inflammation/Immunology
PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of Lysyl Oxidase-like 2/3 (LOXL2/3) with anti-fibrotic activity. PXS-5120A is >300-fold selective for *LOXL2* (K_i of 83 nM; pIC₅₀ of 8.4) over *LOXL* (pIC₅₀ of 5.8) .

HY-114286A

PXS-5153A monohydrochloride 1 Publications Verification	Monoamine Oxidase	Inflammation/Immunology
PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic *(LOXL2/LOXL3)* inhibitor, with an IC₅₀ of <40 nM for LOXL2 across all mammalian species and an IC₅₀ of 63 nM for human LOXL3. PXS-5153A monohydrochloride could reduce crosslinks and ameliorates fibrosis.

HY-151499A

PXS-6302 hydrochloride	Monoamine Oxidase	Inflammation/Immunology
PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor with IC₅₀s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 hydrochloride has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance .

HY-171955

LXG6403	Lipoxygenase Apoptosis Reactive Oxygen Species (ROS) FAK	Cancer
LXG6403 is an orally active and irreversible LOX inhibitor (IC₅₀ = 1.3 μM). LXG6403 is ~3.5-fold more specific for LOX than LOXL2 and does not inhibit LOXL1. LXG6403 inhibits FAK signaling and induces ROS generation and DNA damage, leading to G1 arrest and apoptosis in chemoresistant triple-negative breast cancer (TNBC) cell lines. LXG6403 alters the extracellular matrix (ECM) and collagen structure, reducing collagen cross-linking and deposition, thereby increasing drug penetration and reducing tumor stiffness. LXG6403 overcomes Doxorubicin (HY-15142) resistance in chemoresistant TNBC PDX in vivo and can be used to study high-stiffness resistant tumors .

HY-151499

PXS-6302	Monoamine Oxidase	Others
PXS-6302 is an irreversible lysyl oxidase inhibitor with IC₅₀s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance .

HY-170538

SNT-5382	Lysyl Oxidase Cytochrome P450	Cardiovascular Disease Metabolic Disease
SNT-5382 is a lysyl oxidase family (LOX) inhibitor and anti-fibrotic agent. SNT-5382 binds to the LTQ cofactor of *LOXL2* and inhibits the enzymatic activities of *LOXL3, LOXL4, LOXL1, CYP2C9, and CYP2C19*. SNT-5382 reduces cardiac and liver fibrosis as well as collagen crosslinks, and improves cardiac function. SNT-5382 can be used for the research of heart failure, myocardial infarction, and nonalcoholic steatohepatitis-related liver fibrosis .

HY-114286

PXS-5153A	Monoamine Oxidase	Inflammation/Immunology
PXS-5153A is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic *(LOXL2/LOXL3)* inhibitor, with an IC₅₀ of <40 nM for LOXL2 across all mammalian species and an IC₅₀ of 63 nM for human LOXL3. PXS-5153A could reduce crosslinks and ameliorates fibrosis.

HY-170573A

LOXL2-IN-1 tosylate	Monoamine Oxidase	Cancer
LOX-IN-5 tosylate (compound 22) is a selective and orally active lysyl oxidase-like 2 (LOXL2) inhibitor with an IC₅₀ of <300 nM. LOX-IN-5 tosylate possess anti-fibrosis properties .

HY-151498A

PXS-4787 hydrochloride	Monoamine Oxidase	Others
PXS-4787 hydrochloride is a specific and effective pan-LOX (lysyl oxidase) inhibitor for abolishing lysyl oxidase activity. PXS-4787 hydrochloride inhibits LOX with IC₅₀s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), 0.2 μM (rh LOXL4), respectively. PXS-4787 hydrochloride reduces deposition and crosslinking of collagen I secreted by human fibroblasts .

HY-151498

PXS-4787	Monoamine Oxidase	Others
PXS-4787 is a specific and effective pan-LOX (lysyl oxidase) inhibitor for abolishing lysyl oxidase activity. PXS-4787 inhibits LOX with IC₅₀s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), 0.2 μM (rh LOXL4), respectively .

HY-170573

LOXL2-IN-1	Monoamine Oxidase	Cancer
LOX-IN-5 (compound 22) is a selective and orally active lysyl oxidase-like 2 (LOXL2) inhibitor with an IC₅₀ of <300 nM. LOX-IN-5 possess anti-fibrosis properties .

HY-N0554R

Escin IA (Standard)	Reference Standards HIV Protease	Infection Cancer
Escin IA (Standard) is the analytical standard of Escin IA. This product is intended for research and analytical applications. Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .

HY-107422A

Lenumlostat hydrochloride PAT-1251 hydrochloride; GB2064 hydrochloride	Monoamine Oxidase	Inflammation/Immunology
PAT-1251 Hydrochloride is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC₅₀s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC₅₀s, 0.10, 0.12, and 0.16 μM, respectively). PAT-1251 Hydrochloride is used in the research of fibrotic diseases.

HY-180581

LOXL2/sGC modulator-1	Monoamine Oxidase Guanylate Cyclase	Cardiovascular Disease
LOXL2/sGC modulator-1 (Compound 11k) is a *LOXL2* inhibitor (IC₅₀ = 0.13 μM) and an sGC activator. LOXL2/sGC modulator-1 shows good selectivity for LOX (IC₅₀ > 45.9 μM) and LOXL3 (IC₅₀ = 1.30 μM). LOXL2/sGC modulator-1 significantly increases intracellular cGMP levels in the presence of the gGC inhibitor ODQ (HY-101255). LOXL2/sGC modulator-1 significantly inhibits hypoxia-induced collagen deposition and cross-linking, while promoting vasodilation. LOXL2/sGC modulator-1 can be used for the study of pulmonary arterial hypertension .

HY-183644

LNO 9	Lysyl Oxidase	Cardiovascular Disease
LNO 9 is an orally active *LOXL2* inhibitor and NO donor, with an IC₅₀ of 0.17 μM against human *LOXL2. LNO 9 competitively binds to the LTQ cofactor of LOXL2* to form an irreversible complex, thereby inhibiting collagen oxidation and abnormal cross-linking. LNO 9 releases nitric oxide (NO) to increase cGMP levels in pulmonary artery smooth muscle cells. LNO 9 inhibits hypoxia-induced collagen modification and possesses vasodilatory activity. LNO 9 ameliorates right ventricular hypertrophy and pulmonary artery medial thickness in rat models induced by hypoxia and Monocrotaline (HY-N0750), and can be used for research on pulmonary hypertension .

HY-107422R

Lenumlostat (Standard) PAT-1251 (Standard); GB2064 (Standard)	Reference Standards Monoamine Oxidase	Inflammation/Immunology
Lenumlostat (Standard) is the analytical standard of Lenumlostat (HY-107422). This product is intended for research and analytical applications. PAT-1251 is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC₅₀s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC₅₀s, 0.10, 0.12, and 0.16 μM, respectively); PAT-1251 is used in the research of fibrotic diseases .

HY-101771AR

(2-Chloropyridin-4-yl)methanamine hydrochloride (Standard)	Reference Standards Monoamine Oxidase	Cardiovascular Disease Inflammation/Immunology
(2-Chloropyridin-4-yl)methanamine hydrochloride (Standard) is the analytical standard of (2-Chloropyridin-4-yl)methanamine hydrochloride (HY-101771A). This product is intended for research and analytical applications. (2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor with an IC₅₀ of 126 nM.

Levoleucovorin Levofolinic acid; Levofolene	Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	Lysyl Oxidase Apoptosis
Levoleucovorin (Levofolinic acid; Levofolene) is the pharmacologically and orally active levoisomer of Folinic acid (HY-17556), a synthetic folate analogue. Levoleucovorin can inhibit *LOXL2* with an IC₅₀ of 68.81 μM. Levoleucovorin can inhibit cancer cells proliferation, migration and induce apoptosis. Levoleucovorin can be used as a rescue agent for high-dose Methotrexate (HY-14519). Levoleucovorin can reduce the frequency of embryonic malformations. Levoleucovorin can be used for the research of can and endocrinology, such as breast cancer and osteosarcoma .

Escin IA 1 Publications Verification	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Hippocastanaceae Aesculus hippocastanum Plants Disease Research Fields Source Classification Cancer	HIV Protease Monoamine Oxidase
Escin IA is an oral *LOXL2* inhibitor and EMT inhibitor, with selectivity for *LOXL2*-expressing cells. Escin IA suppresses invasion, migration, and metastasis of breast cancer cells, and acts as the primary anti-TNBC metastasis constituent of Aesculus chinensis Bunge fruit saponin fraction. Escin IA can be used for the research of triple-negative breast cancer, acute inflammation, and ethanol-induced gastric mucosal lesions .

Escin IA (Standard)	Triterpenes Structural Classification other families Terpenoids Hippocastanaceae Aesculus hippocastanum Plants Source Classification	Reference Standards HIV Protease
Escin IA (Standard) is the analytical standard of Escin IA. This product is intended for research and analytical applications. Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .

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