(2-Chloropyridin-4-yl)methanamine hydrochloride
Based on 9 publication(s) in Google Scholar
(2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.87%
- No. CAS: 916210-98-5
- Fòrmula: C6H8Cl2N2
- Peso molecular:179.05
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) (2-Chloropyridin-4-yl)methanamine hydrochloride
More- Bone Res. 2024 Apr 10;12(1):24. [Abstract]
- Chem Eng J. 2025 Aug 1.
- Cell Death Dis. 2025 May 27;16(1):419. [Abstract]
- Aging Cell. 2022 Jul;21(7):e13659. [Abstract]
- Int J Pharm. 2025 Jun 30:679:125730. [Abstract]
- Oncol Rep. 2020 May;43(5):1641-1649. [Abstract]
- Exp Eye Res. 2025 Nov:260:110588. [Abstract]
- Discov Oncol. 2025 Apr 30;16(1):644. [Abstract]
- Cerebrovasc Dis. 2022;51(2):188-198. [Abstract]
Actividad biológica
Descripciòn
IC50 & Target
IC50: 126 nM (LOXL2)[1]
In Vitro
(2-Chloropyridin-4-yl)methanamine hydrochloride is shown to be selective for LOXL2 over LOX and three other amine oxidases (MAO-A, MAO-B and SSAO). In the human whole blood LOXL2 assay, (2-Chloropyridin-4-yl)methanamine hydrochloride has an IC50 of 1.45 μM compared to 126 nM in the absence of blood proteins. (2-Chloropyridin-4-yl)methanamine hydrochloride shows a 31-fold selectivity for LOXL2+BSA (IC50=190 nM) over LOX+BSA (IC50=5.91 μM). Against a panel of non-LTQ-containing AO enzymes (MAO-A, MAO-B and SSAO), LOXL2-IN-1 is found to be inactive at 30 μM. (2-Chloropyridin-4-yl)methanamine hydrochloride is profiled for the inhibition of three different CYP enzymes (CYPs 3A4, 2C9 and 2D6) and in each case the IC50 is more than 30 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 916210-98-5
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Appearance Solid
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Peso molecular 179.05
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Fòrmula C6H8Cl2N2
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Color Light yellow to yellow
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SMILES
[H]Cl.ClC1=NC=CC(CN)=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (9)
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Journal Impact Factor
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Most Recent
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Bone Res
Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization. [Abstract]2024 Apr 10;12(1):24. PMID: 38594260 -
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Cell Death Dis
MMA-induced LOXL2+ PSCs promote linear ECM alignment in the aging pancreas leading to pancreatic cancer progression. [Abstract]2025 May 27;16(1):419. PMID: 40425551 -
Aging Cell
2022 Jul;21(7):e13659. PMID: 35712918 -
Int J Pharm
Bone marrow-targeted LOXL2 inhibitor-loaded yolk-shell nanoparticle overcomes extracellular matrix-mediated chemotherapy resistance in acute myeloid leukemia. [Abstract]2025 Jun 30:679:125730. PMID: 40389070 -
Oncol Rep
LOXL2 upregulates hypoxia‑inducible factor‑1α signaling through Snail‑FBP1 axis in hepatocellular carcinoma cells. [Abstract]2020 May;43(5):1641-1649. PMID: 32323822 -
Exp Eye Res
Lysyl oxidase-like 2 inhibition alleviates subretinal fibrosis in neovascular age-related macular degeneration model. [Abstract]2025 Nov:260:110588. PMID: 40846247 -
Discov Oncol
The increased matrix stiffness caused by LOXL2 activates Piezo1 channels to promote the migration and invasion of cervical cancer cells. [Abstract]2025 Apr 30;16(1):644. PMID: 40304808 -
Cerebrovasc Dis
LOXL2 Inhibitor Attenuates Angiotensin II-Induced Atrial Fibrosis and Vulnerability to Atrial Fibrillation through Inhibition of Transforming Growth Factor Beta-1 Smad2/3 Pathway. [Abstract]2022;51(2):188-198. PMID: 34515064
Solvente y solubilidad
In Vitro:
H2O : 100 mg/mL (558.50 mM; Need ultrasonic)
DMSO : 87.5 mg/mL (488.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (27.93 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 5.5850 mL | 27.9252 mL | 55.8503 mL | 139.6258 mL |
| 5 mM | 1.1170 mL | 5.5850 mL | 11.1701 mL | 27.9252 mL | |
| 10 mM | 0.5585 mL | 2.7925 mL | 5.5850 mL | 13.9626 mL | |
| 15 mM | 0.3723 mL | 1.8617 mL | 3.7234 mL | 9.3084 mL | |
| 20 mM | 0.2793 mL | 1.3963 mL | 2.7925 mL | 6.9813 mL | |
| 25 mM | 0.2234 mL | 1.1170 mL | 2.2340 mL | 5.5850 mL | |
| 30 mM | 0.1862 mL | 0.9308 mL | 1.8617 mL | 4.6542 mL | |
| 40 mM | 0.1396 mL | 0.6981 mL | 1.3963 mL | 3.4906 mL | |
| 50 mM | 0.1117 mL | 0.5585 mL | 1.1170 mL | 2.7925 mL | |
| 60 mM | 0.0931 mL | 0.4654 mL | 0.9308 mL | 2.3271 mL | |
| 80 mM | 0.0698 mL | 0.3491 mL | 0.6981 mL | 1.7453 mL | |
| 100 mM | 0.0559 mL | 0.2793 mL | 0.5585 mL | 1.3963 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(2-Chloropyridin-4-yl)methanamine hydrochloride Related Classifications
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