1. Neuronal Signaling
  2. Monoamine Oxidase
  3. (2-Chloropyridin-4-yl)methanamine hydrochloride

(2-Chloropyridin-4-yl)methanamine hydrochloride 

Cat. No.: HY-101771A Purity: 98.70%
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(2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM.

For research use only. We do not sell to patients.

(2-Chloropyridin-4-yl)methanamine hydrochloride Chemical Structure

(2-Chloropyridin-4-yl)methanamine hydrochloride Chemical Structure

CAS No. : 916210-98-5

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Based on 1 publication(s) in Google Scholar

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(2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM.

IC50 & Target

IC50: 126 nM (LOXL2)[1]

In Vitro

(2-Chloropyridin-4-yl)methanamine hydrochloride is shown to be selective for LOXL2 over LOX and three other amine oxidases (MAO-A, MAO-B and SSAO). In the human whole blood LOXL2 assay, (2-Chloropyridin-4-yl)methanamine hydrochloride has an IC50 of 1.45 µM compared to 126 nM in the absence of blood proteins. (2-Chloropyridin-4-yl)methanamine hydrochloride shows a 31-fold selectivity for LOXL2+BSA (IC50=190 nM) over LOX+BSA (IC50=5.91 µM). Against a panel of non-LTQ-containing AO enzymes (MAO-A, MAO-B and SSAO), LOXL2-IN-1 is found to be inactive at 30 µM. (2-Chloropyridin-4-yl)methanamine hydrochloride is profiled for the inhibition of three different CYP enzymes (CYPs 3A4, 2C9 and 2D6) and in each case the IC50 is more than 30 µM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (279.25 mM)

DMSO : ≥ 33 mg/mL (184.31 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5850 mL 27.9252 mL 55.8503 mL
5 mM 1.1170 mL 5.5850 mL 11.1701 mL
10 mM 0.5585 mL 2.7925 mL 5.5850 mL
*Please refer to the solubility information to select the appropriate solvent.

Purity: 98.70%

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(2-Chloropyridin-4-yl)methanamineMonoamine OxidaseMAOInhibitorinhibitorinhibit

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