modulatory

By Targets:	Bacterial (3) Endogenous Metabolite (1) Enterovirus (1) HDAC (2) Histamine Receptor (1) iGluR (1) Imidazoline Receptor (1) Isotope-Labeled Compounds (2) Keap1-Nrf2 (1) LPL Receptor (1) mGluR (3) NF-κB (3) NO Synthase (1) Potassium Channel (1) Reactive Oxygen Species (1) TGF-β Receptor (1) Virus Protease (1)
By Research Areas:	Cancer (4) Endocrinology (1) Infection (3) Inflammation/Immunology (11) Metabolic Disease (3) Neurological Disease (8)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138799

KA2507	HDAC	Cancer
KA2507 is a potent, orally active and selective HDAC6 inhibitor, with an IC₅₀ of 2.5 nM. KA2507 shows antitumor activities and immune modulatory effects in preclinical models .

HY-101620

MRZ 2-514 1 Publications Verification	iGluR	Neurological Disease
MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with K_i of 33 μM.

HY-103562

DMeOB

3,3'-Dimethoxybenzaldazine
mGluR Neurological Disease

DMeOB is an agonist of mGluR5 receptor with an IC₅₀ of 3 μM. DMeOB has a negative modulatory effect .

DMeOB 3,3'-Dimethoxybenzaldazine	mGluR	Neurological Disease
DMeOB is an agonist of mGluR5 receptor with an IC₅₀ of 3 μM. DMeOB has a negative modulatory effect .

HY-138799A

KA2507 monohydrochloride	HDAC	Inflammation/Immunology Cancer
KA2507 hydrochloride is a potent and highly selective inhibitor of HDAC6 (IC₅₀=2.5 nM) with no significant toxicities. KA2507 hydrochloride shows antitumor efficacy and immune modulatory effects .

HY-148801

Tamuzimod

LPL Receptor Inflammation/Immunology

Tamuzimod is a potent immunomodulator. Tamuzimod has S1P Receptor modulatory activity with EC₅₀s <1 μM .

Tamuzimod	LPL Receptor	Inflammation/Immunology
Tamuzimod is a potent immunomodulator. Tamuzimod has S1P Receptor modulatory activity with EC₅₀s <1 μM .

HY-101238

Agmatine sulfate	Imidazoline Receptor NO Synthase Endogenous Metabolite	Neurological Disease Cancer
Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor.

HY-B0289

Erdosteine 1 Publications Verification RV 144	NF-κB Bacterial	Infection Metabolic Disease Inflammation/Immunology
Erdosteine inhibits lipopolysaccharide (LPS)-induced NF-κB activation . Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects .

HY-B0289S2

Erdosteine-d4 RV 144-d₄	Bacterial NF-κB	Inflammation/Immunology
Erdosteine-d₄ is a deuterium labeled Erdosteine (HY-B0289). Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects[1].

HY-120530

JNJ-46281222	mGluR	Neurological Disease
JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (K_d = 1.7 nM) and a high modulatory potency (pEC₅₀ = 7.71) .

HY-B0289S

Erdosteine-13C4 RV 144-¹³C₄	Isotope-Labeled Compounds NF-κB Bacterial	Infection Metabolic Disease Inflammation/Immunology
Erdosteine- ¹³C₄ is a ¹³C-labeled Erdosteine. Erdosteine inhibits lipopolysaccharide (LPS)-induced NF-κB activation[1][2]. Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects[3].

HY-103021

LY3200882 Maximum Cited Publications 6 Publications Verification	TGF-β Receptor	Inflammation/Immunology Cancer
LY3200882 is a potent, highly selective, ATP-competitive and orally active TGF-β receptor type 1 (ALK5) inhibitor with an IC₅₀ of 38.2 nM. LY3200882 inhibits various pro-tumorigenic activities and is also used as an immune modulatory agent .

HY-100808

D-Serine 1 Publications Verification (R)-Serine
D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration .

HY-103561

DCB	mGluR	Neurological Disease
DCB (3,3′-dichlorobenzaldazine) is an neutral allosteric modulator of themetabotropic glutamate receptor metabotropic glutamate receptor subtype 5 (mGluR5) . DCB blocks the positive allosteric regulation of mGluRs (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB). DCB shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB) .

HY-106161

Rupintrivir 5 Publications Verification AG7088	Virus Protease Enterovirus	Infection Inflammation/Immunology
Rupintrivirvr (AG7088), an antiviral agent, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC₅₀ of 0.023 μM. Rupintrivirvr shows immune-modulatory effect .

HY-17039

Alcaftadine R89674	Histamine Receptor	Inflammation/Immunology Endocrinology
Alcaftadine (R89674) is a histamine H1 receptor antagonist, which is used to prevent eye irritation brought on by allergic conjunctivitis. Alcaftadine is a broad-spectrum antihistamine displaying a high affinity for histamine H1 and H2 receptors and a lower affinity for H4 receptors. Alcaftadine also exhibits modulatory action on immune cell recruitment and mast cell stabilizing effects .

HY-108584

Flindokalner BMS-204352	Potassium Channel	Neurological Disease
Flindokalner (BMS-204352) is a potassium channel modulator. Flindokalner is a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is also a large conductance calcium-activated K channel (BKca) positive modulator. Flindokalner shows a negative modulatory activity at Kv7.1 channels (K_i=3.7 μM), and acts as a negative modulator of GABAA receptors. Flindokalner shows anxiolytic efficacy in vivo .

HY-100808S

D-Serine-d3 (R)-Serine-d₃	Isotope-Labeled Compounds	Neurological Disease
D-Serine-d₃ ((R)-Serine-d₃) is a deuterium labeled D-Serine (HY-100808). D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration .

HY-136651

BNTA	Reactive Oxygen Species	Inflammation/Immunology
BNTA, a potent extracellular matrix (ECM) modulator, facilitates cartilage structural molecule synthesis on chondrocytes by activating superoxide dismutase 3 (SOD3). BNTA shows a promising potential for osteoarthritis alleviation by modulating cartilage generation .

HY-147517

Keap1-Nrf2-IN-9	Keap1-Nrf2	Neurological Disease Inflammation/Immunology
Keap1-Nrf2-IN-9 (compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC₅₀ of 0.575 µM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows not cytotoxic activity in ARPE19 cells .

Cat. No.	Product Name	Target	Research Area

HY-105063

DiaPep277	Peptides	Metabolic Disease Inflammation/Immunology
DiaPep277 is a 24 amino acid peptide derived from positions 437-460 in HSP60. DiaPep277 arrests the progression of β-cell destruction in NOD mice. DiaPep277 has an immune modulatory effect on diabetogenic T cells in animal models of diabetes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-101238

Agmatine sulfate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Imidazoline Receptor NO Synthase Endogenous Metabolite
Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor.

Cat. No.	Compare	Product Name	Species	Source

HY-P75691

	CSEN Protein, Human (His) Calsenilin; A-type potassium channel modulatory protein 3; DREAM; KCNIP3; KCHIP3	Human	E. coli
	CSEN, a calcium-dependent transcriptional repressor, binds to the DRE element of genes including PDYN and FOS. Its affinity for DNA is influenced by calcium, with reduced binding in the presence of calcium and enhanced binding when bound to magnesium. CSEN is implicated in nociception, suggesting a potential role in the regulation of pain sensation. Additionally, it serves as a regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, specifically interacting with channels such as KCND2/Kv4.2 and KCND3/Kv4.3. CSEN modulates these channels' expression at the cell membrane, influencing gating characteristics, inactivation kinetics, and the rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. The diverse functions of CSEN highlight its involvement in both transcriptional regulation and the modulation of ion channel activity, suggesting a multifaceted role in cellular processes. CSEN Protein, Human (His) is the recombinant human-derived CSEN protein, expressed by E. coli , with N-His labeled tag. The total length of CSEN Protein, Human (His) is 256 a.a., with molecular weight of ~29 kDa.


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Cat. No.	Product Name	Chemical Structure

HY-B0289S2

Erdosteine-d4

Erdosteine-d₄ is a deuterium labeled Erdosteine (HY-B0289). Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects[1].

Erdosteine-d4
Erdosteine-d₄ is a deuterium labeled Erdosteine (HY-B0289). Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects[1].

HY-B0289S

Erdosteine-13C4
Erdosteine- ¹³C₄ is a ¹³C-labeled Erdosteine. Erdosteine inhibits lipopolysaccharide (LPS)-induced NF-κB activation[1][2]. Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects[3].

HY-100808S

D-Serine-d3
D-Serine-d₃ ((R)-Serine-d₃) is a deuterium labeled D-Serine (HY-100808). D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration .

D-Serine-d3

D-Serine-d₃ ((R)-Serine-d₃) is a deuterium labeled D-Serine (HY-100808). D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration .

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