1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. iGluR
  3. MRZ 2-514

MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with Ki of 33 μM.

For research use only. We do not sell to patients.

MRZ 2-514 Chemical Structure

MRZ 2-514 Chemical Structure

CAS No. : 202808-11-5

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Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE MRZ 2-514

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Description

MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with Ki of 33 μM.

IC50 & Target

Ki: 33 μM (glycineB)[1]

In Vitro

MRZ 2-514 has IC50 values against peak AMPA-induced currents of 72.7 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MRZ 2/514 has anticonvulsive action in the MES model in mice, and the effect is prolonged by probenecid[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

308.09

Formula

C11H6BrN3O3

CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C1NNC(C2=C1C=C3C=C(Br)C=CC3=[N+]2[O-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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MRZ 2-514 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MRZ 2-514
Cat. No.:
HY-101620
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