2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. DMeOB

DMeOB  (Synonyms: 3,3'-Dimethoxybenzaldazine)

Cat. No.: HY-103562 Purity: 98.55%
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DMeOB is an agonist of mGluR5 receptor with an IC50 of 3 μM. DMeOB has a negative modulatory effect.

For research use only. We do not sell to patients.

DMeOB Chemical Structure

DMeOB Chemical Structure

CAS No. : 40252-74-2

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5 mg USD 80 In-stock
10 mg USD 130 In-stock
25 mg USD 260 In-stock
50 mg USD 400 In-stock
100 mg USD 600 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

DMeOB is an agonist of mGluR5 receptor with an IC50 of 3 μM. DMeOB has a negative modulatory effect[1].

Molecular Weight

268.31

Formula

C16H16N2O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

COC1=CC(/C=N/N=C/C2=CC=CC(OC)=C2)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (372.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7270 mL 18.6352 mL 37.2703 mL
5 mM 0.7454 mL 3.7270 mL 7.4541 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7270 mL 18.6352 mL 37.2703 mL 93.1758 mL
5 mM 0.7454 mL 3.7270 mL 7.4541 mL 18.6352 mL
10 mM 0.3727 mL 1.8635 mL 3.7270 mL 9.3176 mL
15 mM 0.2485 mL 1.2423 mL 2.4847 mL 6.2117 mL
20 mM 0.1864 mL 0.9318 mL 1.8635 mL 4.6588 mL
25 mM 0.1491 mL 0.7454 mL 1.4908 mL 3.7270 mL
30 mM 0.1242 mL 0.6212 mL 1.2423 mL 3.1059 mL
40 mM 0.0932 mL 0.4659 mL 0.9318 mL 2.3294 mL
50 mM 0.0745 mL 0.3727 mL 0.7454 mL 1.8635 mL
60 mM 0.0621 mL 0.3106 mL 0.6212 mL 1.5529 mL
80 mM 0.0466 mL 0.2329 mL 0.4659 mL 1.1647 mL
100 mM 0.0373 mL 0.1864 mL 0.3727 mL 0.9318 mL
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DMeOB Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DMeOB40252-74-23,3'-DimethoxybenzaldazinemGluRMetabotropic glutamate receptorsmGluRsAnxietySchizophreniaInhibitorinhibitorinhibit

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