1. Anti-infection
  2. Virus Protease
    Enterovirus
  3. Rupintrivir

Rupintrivir (Synonyms: AG7088)

Cat. No.: HY-106161
Handling Instructions

Rupintrivirvr (AG7088), an antiviral drug, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC50 of 0.023 μM. Rupintrivirvr shows immune-modulatory effect.

For research use only. We do not sell to patients.

Rupintrivir Chemical Structure

Rupintrivir Chemical Structure

CAS No. : 223537-30-2

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Description

Rupintrivirvr (AG7088), an antiviral drug, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC50 of 0.023 μM. Rupintrivirvr shows immune-modulatory effect[1][2].

In Vitro

In H1-HeLa and MRC-5 cell protection assays, Rupintrivirvr (AG7088) inhibited the replication of all HRV serotypes (48 of 48) tested with a mean 50% effective concentration (EC50) of 0.023 μM (range, 0.003 to 0.081 μM) and a mean EC90 of 0.082 μM (range, 0.018 to 0.261 μM) as well as that of related picornaviruses including coxsackieviruses A21 and B3, enterovirus 70, and echovirus 11[1].

In Vivo

Rupintrivirvr (AG7088) reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo[2].

Molecular Weight

598.66

Formula

C₃₁H₃₉FN₄O₇

CAS No.

223537-30-2

SMILES

O=C(OCC)/C=C/[[email protected]@H](NC([[email protected]](CC1=CC=C(F)C=C1)CC([[email protected]@H](NC(C2=NOC(C)=C2)=O)C(C)C)=O)=O)C[[email protected]]3C(NCC3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

RupintrivirAG7088AG 7088AG-7088Virus ProteaseEnterovirusRhinovirusHRVHRVsHEVHEVsantiviralreplicationserotypeimmune-modulatorycytokinelungslicesInhibitorinhibitorinhibit

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Rupintrivir
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HY-106161
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