1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. KA2507

KA2507 

Cat. No.: HY-138799
Handling Instructions

KA2507 is a potent and selective HDAC6 inhibitor, with an IC50 of 2.5 nM. KA2507 shows antitumor activities and immune modulatory effects in preclinical models.

For research use only. We do not sell to patients.

KA2507 Chemical Structure

KA2507 Chemical Structure

CAS No. : 1636894-46-6

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Description

KA2507 is a potent and selective HDAC6 inhibitor, with an IC50 of 2.5 nM. KA2507 shows antitumor activities and immune modulatory effects in preclinical models[1].

IC50 & Target[1]

HDAC6

2.5 nM (IC50)

HDAC1

9895 nM (IC50)

HDAC4

9613 nM (IC50)

HDAC5

1997 nM (IC50)

HDAC7

2333 nM (IC50)

HDAC8

621 (IC50)

HDAC9

5648 nM (IC50)

In Vitro

KA2507 did not inhibit the in vitro proliferation of mouse or human cancer cells at concentrations that are selective for HDAC6 inhibition[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KA2507 (100-200 mg/kg; i.g.; daily; for 20 days) inhibits tumor growth in the syngeneic B16-F10 mouse melanoma model[1].
KA2507 exhibits poor oral bioavailability (mice 15%) and Cmax (mice 300 ng/mL) following oral administration (mice 200 mg/kg)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice, B16-F10 melanoma model[1]
Dosage: 100 mg/kg, 200 mg/kg, 200 mg/kg
Administration: Oral gavage, daily, for 20 days
Result: Demonstrated antitumor efficacy.
Animal Model: Male C57BL/6 mice[1]
Dosage: 200 mg/kg (Pharmacokinetic Analysis)
Administration: Oral administration
Result: Oral bioavailability (15%), Cmax (300 ng/mL).
Molecular Weight

322.32

Formula

C₁₆H₁₄N₆O₂

CAS No.
SMILES

O=C(NO)C1=CC=C(CN(C2=NC=CN=C2)C3=NC=CN=C3)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

KA2507KA 2507KA-2507HDACHistone deacetylasesantitumorimmunemodulatorymelanomaInhibitorinhibitorinhibit

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KA2507
Cat. No.:
HY-138799
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