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BNTA 

Cat. No.: HY-136651
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BNTA, a potent extracellular matrix (ECM) modulator, facilitates cartilage structural molecule synthesis on chondrocytes by activating superoxide dismutase 3 (SOD3). BNTA promotes cartilage extracellular matrix generation and inhibits osteoarthritis development. BNTA has the potential for the research of osteoarthritis.

For research use only. We do not sell to patients.

BNTA Chemical Structure

BNTA Chemical Structure

CAS No. : 685119-25-9

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10 mM * 1 mL in DMSO USD 301 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
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10 mg USD 500 In-stock
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25 mg USD 950 In-stock
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50 mg USD 1550 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

BNTA, a potent extracellular matrix (ECM) modulator, facilitates cartilage structural molecule synthesis on chondrocytes by activating superoxide dismutase 3 (SOD3). BNTA promotes cartilage extracellular matrix generation and inhibits osteoarthritis development. BNTA has the potential for the research of osteoarthritis[1].

In Vitro

BNTA (0.01-10 μM; 1-7 d) does not decrease cell viability of human osteoarthritis chondrocytes and rat primary chondrocytes[1].
BNTA (0.1 μM; 2 d) increases SOX9 protein markedly[1].
BNTA (0.1 μM; 2 d) remarkably increases the COL2A1 and SOX9 protein levels in IL1β-induced rat OA chondrocytes[1].
BNTA (10 μM; 5 d) increases proteoglycan staining in ATDC5 cells[1].
BNTA (0.01-10 μM; 6 h) upregulates the expression levels of ECM-related genes COL2A1, ACAN, proteoglycan 4 (PRG4), and SRY-box 9 (SOX9) in human OA chondrocytes[1].
BNTA (0.01-10 μM; 6 h) increases Col2a1, Acan, Prg4, and Sox9 mRNA levels, with maximum effects around 0.1 μM in IL1β-induced rat OA chondrocytes[1].
BNTA (0.01-1 μM; 2 or 3 w) enhances anabolism and inhibited inflammatory response in osteoarthritis cartilage explants[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human OA chondrocytes
Concentration: 0.01, 0.1, 1, 10 μM
Incubation Time: 1, 3, 5, 7 d
Result: No toxicity was observed.

Western Blot Analysis[1]

Cell Line: Human OA chondrocytes
Concentration: 0.1 μM
Incubation Time: 2 d
Result: Elevated SOX9 protein compared with vehicle.
In Vivo

BNTA (0.015-1.5 mg/kg; intra-articular injection; twice a week for 4 and 8 weeks) could attenuate OA progression developed after anterior cruciate ligament transection (ACLT) in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SD rats weighing 80 g are induced by ACLT[1]
Dosage: 0.015, 0.15, 1.5 mg/kg
Administration: Intra-articular injection; twice a week for 4 and 8 weeks
Result: Attenuated post-traumatic osteoarthritis development after intra-articular injection for 4 and 8 weeks and was well tolerated.
Molecular Weight

456.76

Formula

C₁₇H₁₁BrClNO₃S₂

CAS No.

685119-25-9

SMILES

O=C(NC1=C(Br)SC=C1S(=O)(C2=CC=CC=C2)=O)C3=CC=CC=C3Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BNTAOthersextracellularmatrixECMmodulatorypropertiescartilagechondrocytessuperoxidedismutase3SOD3osteoarthritisInhibitorinhibitorinhibit

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