Cat. No.: HY-100808

D-Serine

(Synonyms: (R)-Serine)

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration.

For research use only. We do not sell to patients.

Purity: 98.0%
CAS No.: 312-84-5
Formula: C₃H₇NO₃
Molecular Weight:105.09

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

D-Serine Chemical Structure

CAS No.: 312-84-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target

NMDA Receptor

Human Endogenous Metabolite

All iGluR Isoforms :

All Endogenous Metabolite Isoforms :

In Vitro

(R)-Serine is synthesized from L-Ser by serine racemase (SR) and degraded by D-amino acid oxidase (DAAO) and SR. Distribution of D-Ser and NMDAR as determined by chemical measurement and immunohistochemistry supports D-Ser as an endogenous coagonist acting on the glycine modulatory site of the NR1 subunits of the NMDAR^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(R)-Serine (10 g/L; p.o.; throughout 8 weeks) regulates HFD induced weight gain^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Four week old male C57Bl/6 mice
Dosage:

10 g/L
Administration:

Oral administration (drinking water supplemented with 10 g/l D-serine); throughout 8 weeks
Result:

Showed strongly reduced weight gain during the first week of supplementation with paralleled weight gain to HFD fed mice, but no catch up thereafter.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 312-84-5
Appearance Solid
Molecular Weight 105.09
Formula C₃H₇NO₃
Color White to off-white
SMILES

N[C@H](CO)C(O)=O
Synonyms

(R)-Serine
Structure Classification
- Amino acids
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (2)

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Journal Impact Factor

Front Immunol

Repetitive transcranial magnetic stimulation alleviates neuropathic pain via microglial polarization by modulating the METTL3/NMDAR2B/NLRP3 pathway. [Abstract]

2026 Jan 26:16:1666920. PMID: 41668762
Research Square Preprint

2022 Jan.

Solvent & Solubility

In Vitro:

H₂O : ≥ 50 mg/mL (475.78 mM)

Methanol : < 1 mg/mL (insoluble)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

9.5157 mL

47.5783 mL

95.1565 mL

5 mM

1.9031 mL

9.5157 mL

19.0313 mL

10 mM

0.9516 mL

4.7578 mL

9.5157 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 50 mg/mL (475.78 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Andrea R. Durrant, et al. D-Serine in Neuropsychiatric Disorders: New Advances.

[2]. MacKay MB, et al. D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression? Front Psychiatry. 2019 Feb 6;10:25. [Content Brief]

[3]. Dai X, et al. D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10(1):1986. [Content Brief]

[4]. Suwandhi L, et al. Chronic d-serine supplementation impairs insulin secretion. Mol Metab. 2018 Oct;16:191-202. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	9.5157 mL	47.5783 mL	95.1565 mL	237.8913 mL
	5 mM	1.9031 mL	9.5157 mL	19.0313 mL	47.5783 mL
	10 mM	0.9516 mL	4.7578 mL	9.5157 mL	23.7891 mL
	15 mM	0.6344 mL	3.1719 mL	6.3438 mL	15.8594 mL
	20 mM	0.4758 mL	2.3789 mL	4.7578 mL	11.8946 mL
	25 mM	0.3806 mL	1.9031 mL	3.8063 mL	9.5157 mL
	30 mM	0.3172 mL	1.5859 mL	3.1719 mL	7.9297 mL
	40 mM	0.2379 mL	1.1895 mL	2.3789 mL	5.9473 mL
	50 mM	0.1903 mL	0.9516 mL	1.9031 mL	4.7578 mL
	60 mM	0.1586 mL	0.7930 mL	1.5859 mL	3.9649 mL
	80 mM	0.1189 mL	0.5947 mL	1.1895 mL	2.9736 mL
	100 mM	0.0952 mL	0.4758 mL	0.9516 mL	2.3789 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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D-Serine

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Publications Citing Use of MedChemExpress (MCE) D-Serine

All iGluR Isoforms

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

D-Serine Related Classifications

Cat. No.: HY-100808