1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. iGluR
    Endogenous Metabolite
  3. (R)-Serine

(R)-Serine 

Cat. No.: HY-100808 Purity: >98.0%
Handling Instructions

(R)-Serine, an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. (R)-Serine has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration.

For research use only. We do not sell to patients.

(R)-Serine Chemical Structure

(R)-Serine Chemical Structure

CAS No. : 312-84-5

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Based on 1 publication(s) in Google Scholar

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Description

(R)-Serine, an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. (R)-Serine has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

(R)-Serine is synthesized from L-Ser by serine racemase (SR) and degraded by D-amino acid oxidase (DAAO) and SR. Distribution of D-Ser and NMDAR as determined by chemical measurement and immunohistochemistry supports D-Ser as an endogenous coagonist acting on the glycine modulatory site of the NR1 subunits of the NMDAR[3].

In Vivo

(R)-Serine (10 g/L; p.o.; throughout 8 weeks) regulates HFD induced weight gain[4].

Animal Model: Four week old male C57Bl/6 mice
Dosage: 10 g/L
Administration: Oral administration (drinking water supplemented with 10 g/l D-serine); throughout 8 weeks
Result: Showed strongly reduced weight gain during the first week of supplementation with paralleled weight gain to HFD fed mice, but no catch up thereafter.
Molecular Weight

105.09

Formula

C₃H₇NO₃

CAS No.

312-84-5

SMILES

N[[email protected]](CO)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (475.78 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.5157 mL 47.5783 mL 95.1565 mL
5 mM 1.9031 mL 9.5157 mL 19.0313 mL
10 mM 0.9516 mL 4.7578 mL 9.5157 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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(R)-Serine
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HY-100808
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