2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. iGluR Endogenous Metabolite
  4. D-Serine

D-Serine  (Synonyms: (R)-Serine)

Cat. No.: HY-100808 Purity: ≥98.0%
COA Handling Instructions

D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration.

For research use only. We do not sell to patients.

D-Serine Chemical Structure

D-Serine Chemical Structure

CAS No. : 312-84-5

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Solution
10 mM * 1 mL in Water USD 61 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 61 In-stock
Solid
500 mg USD 55 In-stock
1 g USD 66 In-stock
5 g USD 77 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of D-Serine:

D-Serine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE D-Serine

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2].

IC50 & Target

NMDA Receptor

 

Human Endogenous Metabolite

 

In Vitro

(R)-Serine is synthesized from L-Ser by serine racemase (SR) and degraded by D-amino acid oxidase (DAAO) and SR. Distribution of D-Ser and NMDAR as determined by chemical measurement and immunohistochemistry supports D-Ser as an endogenous coagonist acting on the glycine modulatory site of the NR1 subunits of the NMDAR[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

D-Serine Related Antibodies
In Vivo

(R)-Serine (10 g/L; p.o.; throughout 8 weeks) regulates HFD induced weight gain[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four week old male C57Bl/6 mice
Dosage: 10 g/L
Administration: Oral administration (drinking water supplemented with 10 g/l D-serine); throughout 8 weeks
Result: Showed strongly reduced weight gain during the first week of supplementation with paralleled weight gain to HFD fed mice, but no catch up thereafter.
Clinical Trial
Molecular Weight

105.09

Appearance

Solid

Formula

C3H7NO3
CAS No.
SMILES

N[C@H](CO)C(O)=O
Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (475.78 mM)

Methanol : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.5157 mL 47.5783 mL 95.1565 mL
5 mM 1.9031 mL 9.5157 mL 19.0313 mL
10 mM 0.9516 mL 4.7578 mL 9.5157 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (475.78 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

COA (245 KB) HNMR (83 KB)

Handling Instructions (2659 KB)
References
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D-Serine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

D-Serine312-84-5(R)-SerineiGluREndogenous MetaboliteIonotropic glutamate receptorsInhibitorinhibitorinhibit

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