D-Phenylalanine
Based on 1 Customer Validation
D-Phenylalanine is an atypical D-amino acid and an inhibitor of bacterial biofilm formation. D-Phenylalanine mainly replaces D-alanine (D-Ala) by incorporating into the fourth and fifth positions of bacterial peptidoglycan (PG), changing the cell wall structure, enhancing bacterial acid resistance and affecting biofilm formation. D-Phenylalanine may promote the secretion of peptide tyrosine tyrosine (PYY) in mammals by activating the intestinal GPR109B receptor. D-Phenylalanine can inhibit the maturation of microbial biofilms and promote the release of specific hormones. It can be used for antibacterial preservation, improving the yield of probiotics in the food industry, and studying appetite regulation and blood sugar control in metabolic diseases such as diabetes.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 673-06-3
- Formula: C9H11NO2
- Molecular Weight:165.19
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Biological Activity
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Human Endogenous Metabolite |
D-Phenylalanine (50 mM; 1.5 h, 2 h) improves the survival rate of Lactococcus lactis F44 at pH 3.0[1].
D-Phenylalanine (50 mM; 6 h, 8 h, 10 h) increases the production of Nisin (HY-P1607) in Lactococcus lactis F44[1].
D-Phenylalanine (10 mM; 2-10 days) inhibits the maturation of multilayer biofilms of the marine microorganism Pseudoalteromonas sp. SC2014, reduces the number of attached cells, and promotes the decomposition of the formed multilayer biofilm into a monolayer structure, but does not affect the viability of planktonic cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Lactococcus lactis F44
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Concentration:50 mM
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Incubation Time:1.5 h, 2 h
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Result:Increased the survival rate of L. lactis F44 at pH 3.0 by 58.33% and 79.53% after 1.5 h and 2 h of acid shock, respectively.
Chemical Information
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CAS No. 673-06-3
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Appearance Solid
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Molecular Weight 165.19
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Formula C9H11NO2
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Color White to off-white
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SMILES
N[C@H](CC1=CC=CC=C1)C(O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
H2O : 4.17 mg/mL (25.24 mM; Need ultrasonic)
DMSO : 1 mg/mL (6.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 2 mg/mL (12.11 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Purity & Documentation
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Data Sheet (274 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Wu H, et al. d-Methionine and d-Phenylalanine Improve Lactococcus lactis F44 Acid Resistance and Nisin Yield by Governing Cell Wall Remodeling. Appl Environ Microbiol. 2020 Apr 17;86(9):e02981-19. [Content Brief]
[2]. Li E, et al. D-Phenylalanine inhibits biofilm development of a marine microbe, Pseudoalteromonas sp. SC2014. FEMS Microbiol Lett. 2016 Sep;363(18). [Content Brief]
[3]. Amin A, et al. Differential effects of L- and D-phenylalanine on pancreatic and gastrointestinal hormone release in humans: A randomized crossover study. Diabetes Obes Metab. 2021 Jan;23(1):147-157. [Content Brief]
[4]. Walsh NE, et al. Analgesic effectiveness of D-phenylalanine in chronic pain patients. Arch Phys Med Rehabil. 1986 Jul;67(7):436-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 6.0536 mL | 30.2682 mL | 60.5364 mL | 151.3409 mL |
| 5 mM | 1.2107 mL | 6.0536 mL | 12.1073 mL | 30.2682 mL | |
| H2O | 10 mM | 0.6054 mL | 3.0268 mL | 6.0536 mL | 15.1341 mL |
| 15 mM | 0.4036 mL | 2.0179 mL | 4.0358 mL | 10.0894 mL | |
| 20 mM | 0.3027 mL | 1.5134 mL | 3.0268 mL | 7.5670 mL | |
| 25 mM | 0.2421 mL | 1.2107 mL | 2.4215 mL | 6.0536 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
D-Phenylalanine Related Classifications
HY-Y0079 Related Classifications
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