1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. D-Leucine

D-Leucine (Synonyms: (R)-Leucine)

Cat. No.: HY-Y0378
Handling Instructions

D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro.

For research use only. We do not sell to patients.

D-Leucine Chemical Structure

D-Leucine Chemical Structure

CAS No. : 328-38-1

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Description

D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

In a screen of candidate neuronal receptors, D-leucine failed to compete for binding by cognate ligands, potentially suggesting a novel target. Even at low doses, D-leucine suppressed ongoing seizures at least as effectively as diazepam but without sedative effects. These studies raise the possibility that D-leucine may represent a new class of anti-seizure agents, and that D-leucine may have a previously unknown function in eukaryotes[1].

Molecular Weight

131.17

Formula

C₆H₁₃NO₂

CAS No.

328-38-1

SMILES

N[[email protected]](CC(C)C)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

D-Leucine(R)-LeucineEndogenous MetaboliteInhibitorinhibitorinhibit

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