1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. D-Leucine

D-Leucine  (Synonyms: (R)-Leucine)

Cat. No.: HY-Y0378 Purity: ≥98.0%
COA Handling Instructions

D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro.

For research use only. We do not sell to patients.

D-Leucine Chemical Structure

D-Leucine Chemical Structure

CAS No. : 328-38-1

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Based on 1 publication(s) in Google Scholar

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Description

D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

In a screen of candidate neuronal receptors, D-leucine failed to compete for binding by cognate ligands, potentially suggesting a novel target. Even at low doses, D-leucine suppressed ongoing seizures at least as effectively as diazepam. These studies raise the possibility that D-leucine may represent a new class of anti-seizure agents, and that D-leucine may have a previously unknown function in eukaryotes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

131.17

Formula

C6H13NO2

CAS No.
SMILES

N[[email protected]](CC(C)C)C(O)=O

Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (76.24 mM; ultrasonic and warming and heat to 60°C)

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.6237 mL 38.1185 mL 76.2369 mL
5 mM 1.5247 mL 7.6237 mL 15.2474 mL
10 mM 0.7624 mL 3.8118 mL 7.6237 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: ≥98.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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D-Leucine
Cat. No.:
HY-Y0378
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