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Pathways Recommended:	Neuronal Signaling

Results for "

neuronal nuclei

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AP-1 (2) Cyclic GMP-AMP Synthase (1) DNA Alkylator/Crosslinker (1) Photosensitizer (1) PKA (2) STING (1)
By Research Areas:	Cancer (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P10927A

BRP TFA BRINP2-related peptide TFA	PKA AP-1	Metabolic Disease
BRP (BRINP2-related peptide) TFA is a 12-peptide derived from BRINP2 that can cross the blood-brain barrier. BRP TFA induces the central activation of FOS in neuronal cells via the cAMP-PKA-CREB signaling pathway. BRP TFA exerts anorectic and anti-obesity effects without triggering nausea or aversive responses. The action of BRP TFA is independent of the leptin, GLP-1 receptor and melanocortin 4 receptor pathways. BRP TFA is applicable to obesity-related research .

HY-P10927

BRP BRINP2-related peptide	AP-1 PKA	Metabolic Disease
BRP is a 12-peptide derived from BRINP2 that can cross the blood-brain barrier. BRP induces the central activation of FOS in neuronal cells via the cAMP-PKA-CREB signaling pathway. BRP exerts anorectic and anti-obesity effects without triggering nausea or aversive responses. The action of BRP is independent of the leptin, GLP-1 receptor and melanocortin 4 receptor pathways. BRP is applicable to obesity-related research .

HY-W112938

TMPyP tetrachloride	DNA Alkylator/Crosslinker Photosensitizer	Infection Cancer
TMPyP tetrachloride is a DNA-binding agent, singlet oxygen Sensitizer and photobleaching agent. TMPyP tetrachloride binds to DNA via intercalation or external groove complexation; irradiation induces its photoinduced release from DNA. TMPyP tetrachloride sensitizes the generation of singlet molecular oxygen upon irradiation, and prolonged irradiation leads to photobleaching. TMPyP tetrachloride initially localizes preferentially in neuronal nuclei and cytoplasm, and irradiation triggers its subcellular relocalization. TMPyP tetrachloride binds to K ⁺-free single-molecule G4-DNA nanowires via intercalation, and binds to K ⁺-type variants via non-intercalation. TMPyP tetrachloride can be used in studies related to cancer, HIV infection and bacterial infection .

HY-138646

Poly(deoxyadenylic-thymidylic) acid sodium 4 Publications Verification Poly(dA:dT) sodium	Cyclic GMP-AMP Synthase STING	Inflammation/Immunology
Poly(deoxyadenylic-thymidylic) acid (Poly(dA:dT)) sodium is a double-stranded DNA stimulant. Poly(deoxyadenylic-thymidylic) acid sodium is recognized by the intracellular DNA sensor DDX41 and activates the innate immune pathway via the adaptor protein STING, inducing the production of cytokines such as type I interferons. Poly(deoxyadenylic-thymidylic) acid sodium also serves as an in vitro transcription template for free RNA polymerase .

Cat. No.	Product Name	Type

HY-W112938

TMPyP tetrachloride	Biochemical Assay Reagents
TMPyP tetrachloride is a DNA-binding agent, singlet oxygen Sensitizer and photobleaching agent. TMPyP tetrachloride binds to DNA via intercalation or external groove complexation; irradiation induces its photoinduced release from DNA. TMPyP tetrachloride sensitizes the generation of singlet molecular oxygen upon irradiation, and prolonged irradiation leads to photobleaching. TMPyP tetrachloride initially localizes preferentially in neuronal nuclei and cytoplasm, and irradiation triggers its subcellular relocalization. TMPyP tetrachloride binds to K ⁺-free single-molecule G4-DNA nanowires via intercalation, and binds to K ⁺-type variants via non-intercalation. TMPyP tetrachloride can be used in studies related to cancer, HIV infection and bacterial infection .

TMPyP tetrachloride

Biochemical Assay Reagents

TMPyP tetrachloride is a DNA-binding agent, singlet oxygen Sensitizer and photobleaching agent. TMPyP tetrachloride binds to DNA via intercalation or external groove complexation; irradiation induces its photoinduced release from DNA. TMPyP tetrachloride sensitizes the generation of singlet molecular oxygen upon irradiation, and prolonged irradiation leads to photobleaching. TMPyP tetrachloride initially localizes preferentially in neuronal nuclei and cytoplasm, and irradiation triggers its subcellular relocalization. TMPyP tetrachloride binds to K ⁺-free single-molecule G4-DNA nanowires via intercalation, and binds to K ⁺-type variants via non-intercalation. TMPyP tetrachloride can be used in studies related to cancer, HIV infection and bacterial infection .

Cat. No.	Product Name	Target	Research Area

HY-P10927A

BRP TFA BRINP2-related peptide TFA	PKA AP-1	Metabolic Disease
BRP (BRINP2-related peptide) TFA is a 12-peptide derived from BRINP2 that can cross the blood-brain barrier. BRP TFA induces the central activation of FOS in neuronal cells via the cAMP-PKA-CREB signaling pathway. BRP TFA exerts anorectic and anti-obesity effects without triggering nausea or aversive responses. The action of BRP TFA is independent of the leptin, GLP-1 receptor and melanocortin 4 receptor pathways. BRP TFA is applicable to obesity-related research .

HY-P10927

BRP BRINP2-related peptide	AP-1 PKA	Metabolic Disease
BRP is a 12-peptide derived from BRINP2 that can cross the blood-brain barrier. BRP induces the central activation of FOS in neuronal cells via the cAMP-PKA-CREB signaling pathway. BRP exerts anorectic and anti-obesity effects without triggering nausea or aversive responses. The action of BRP is independent of the leptin, GLP-1 receptor and melanocortin 4 receptor pathways. BRP is applicable to obesity-related research .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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