Search Result

Results for "

phosphoglycerate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Phosphoglycerate Dehydrogenase (PHGDH) (7) CDK (1) Endogenous Metabolite (1) Keap1-Nrf2 (1) Phosphatase (5)
By Research Areas:	Cancer (14) Endocrinology (1) Infection (1) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Recombinant Proteins

Targets Recommended: Phosphoglycerate Dehydrogenase (PHGDH)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2822

Phosphoglycerate kinase, yeast PGK	Endogenous Metabolite	Infection Endocrinology Cancer
Phosphoglycerate kinase, yeast (PGK), namely phosphoglycerate kinase, is a glycolytic enzyme commonly used in biochemical research. Phosphoglycerate kinase can catalyze the reversible transfer of phosphate groups from 1,3-bisphosphoglycerate (1,3-BPG) to ADP to generate 3-phosphoglycerate (3-PG) and ATP. At the same time, it can also participate in gluconeogenesis, catalyzing the opposite reaction to produce 1,3BPGA and ADP. Phosphoglycerate kinase is involved in energy metabolism, interaction with nucleic acid, tumor progression, cell death and virus replication and other related processes .

HY-148570

PHGDH-IN-3	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor. PHGDH-IN-3 inhibits PHGDH with an IC₅₀ value of 2.8 μM. PHGDH-IN-3 can be used for the research of cancer .

HY-134205A

CBR-470-1 1 Publications Verification	Keap1-Nrf2	Neurological Disease Metabolic Disease
CBR-470-1 is an inhibitor of the *glycolytic enzyme phosphoglycerate* kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2** activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP ⁺-induced cytotoxicity through activation of the Keap1-Nrf2 cascade .

HY-101966

NCT-503

10+ Cited Publications

Phosphoglycerate Dehydrogenase (PHGDH) Cancer

NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC₅₀ of 2.5 µM.
HY-101143

PGMI-004A

Phosphatase Cancer

PGMI-004A is a potent phosphoglycerate mutase 1 (PGAM1) inhibitor with an IC₅₀ of 13.1 μM.
HY-160252

PHGDH-IN-4

Phosphoglycerate Dehydrogenase (PHGDH) Cancer

PHGDH-IN-4 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor. PHGDH-IN-4 can be used for the research of cancer .
HY-128681

PGAM1-IN-1

1 Publications Verification

Phosphatase Cancer

PGAM1-IN-1 is a phosphoglycerate mutase 1 (PGAM1) inhibitor with an IC₅₀ of 6.4 μM .
HY-128682

PGAM1-IN-2

Phosphatase Cancer

PGAM1-IN-2 is a phosphoglycerate mutase 1 (PGAM1) inhibitor with an IC₅₀ of 2.1 μM .

NCT-503 10+ Cited Publications	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC₅₀ of 2.5 µM.

PGMI-004A	Phosphatase	Cancer
PGMI-004A is a potent phosphoglycerate mutase 1 (PGAM1) inhibitor with an IC₅₀ of 13.1 μM.

PHGDH-IN-4	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
PHGDH-IN-4 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor. PHGDH-IN-4 can be used for the research of cancer .

PGAM1-IN-1 1 Publications Verification	Phosphatase	Cancer
PGAM1-IN-1 is a phosphoglycerate mutase 1 (PGAM1) inhibitor with an IC₅₀ of 6.4 μM .

PGAM1-IN-2	Phosphatase	Cancer
PGAM1-IN-2 is a phosphoglycerate mutase 1 (PGAM1) inhibitor with an IC₅₀ of 2.1 μM .

HY-123269

PKUMDL-WQ-2101	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
PKUMDL-WQ-2101 is a non-NAD ⁺-competing allosteric phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC₅₀ of 34.8 μM. PKUMDL-WQ-2101 exhibits antitumor activity .

HY-117240

NCT-502 5 Publications Verification	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
NCT-502 is a human phosphoglycerate dehydrogenase (PHGDH) inhibitor, cytotoxic to PHGDH-dependent cancer cells, and reduces glucose-derived serine production, with an IC₅₀ of 3.7 μM against PHGDH .

HY-138877A

Phosphoglycolic acid lithium	Phosphatase	Cancer
Phosphoglycolic acid (lithium) is a competitive inhibitor of phosphoglycerate mutase (PGAM)-B, an enzyme of the glycolytic pathway. Phosphoglycolic acid increases basal and fMLF-induced levels of G6P in intact neutrophils. Phosphoglycolic acid thereby increases upstream intermediates in neutrophils, thereby amplifying the respiratory oxidative burst .

HY-126254

BI-4924 1 Publications Verification	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC₅₀=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC₅₀ of 2200 nM at 72 h .

HY-100012

CBR-5884 Maximum Cited Publications 16 Publications Verification	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC₅₀ of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis .

HY-148510

HKB99	Phosphatase	Cancer
HKB99 is an allosteric inhibitor of phosphoglycerate mutase 1 (PGAM1). HKB99 inhibits the formation of invasive pseudopodia and increases the level of PAI-2 in vitro. HKB99 increases the oxidative stress, activates JNK/c-Jun and suppresses AKT and ERK. HKB99 can be used for the research of non-small-cell lung cancer (NSCLC) .

HY-15154

NG 52 4 Publications Verification Compound 52	CDK	Cancer
NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC₅₀s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC₅₀ of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p .

Species:	Human (5) Mouse (1)
Tag:	His (5) Tag Free (1) Strep (1)
Source:	HEK293 (1) Sf9 insect cells (2) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P74634

	PGK1 Protein, Mouse (sf9, His) phosphoglycerate kinase 1; Primer recognition protein 2; PGK1; PGKA	Mouse	Sf9 insect cells
	PGK1 protein catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate, playing a central role in ATP production. It also acts as a polymerase alpha cofactor protein, potentially involved in primer recognition. PGK1's importance extends beyond glycolysis, with potential implications in sperm motility and reproduction. Overall, PGK1 is a multifaceted protein that influences energy metabolism and cellular functions, contributing to cellular physiology. PGK1 Protein, Mouse (sf9, His) is the recombinant mouse-derived PGK1 protein, expressed by Sf9 insect cells, with C-His labeled tag. The total length of PGK1 Protein, Mouse (sf9, His) is 417 a.a., with molecular weight of ~46 kDa.

HY-P71049

	PGK1 Protein, Human (HEK293, His) phosphoglycerate kinase 1; Cell migration-inducing gene 10 protein; Primer recognition protein 2; PGK1; PGKA	Human	HEK293
	The PGK1 protein plays a key role in the glycolysis pathway by catalyzing one of two ATP-generating reactions, promoting the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate. In addition to its glycolytic function, PGK1 appears to act as a cofactor protein for polymerase α, playing a role in primer recognition. PGK1 Protein, Human (HEK293, His) is the recombinant human-derived PGK1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PGK1 Protein, Human (HEK293, His) is 416 a.a., with molecular weight of 46-50 kDa.

HY-P701962

	PGAM1 Protein, Human PGAM1; phosphoglycerate mutase 1; BPG-dependent PGAM 1; phosphoglycerate mutase isozyme B; PGAM-B	Human	E. coli
	PGAM1 protein plays a pivotal role in glycolysis by catalyzing the vital interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Additionally, it is instrumental in the conversion of (2R)-2,3-bisphosphoglycerate to (2R)-3-phospho-glyceroyl phosphate, further contributing to the intricate metabolic processes associated with glycolytic pathways. PGAM1 Protein, Human is the recombinant human-derived PGAM1 protein, expressed by E. coli , with tag free. The total length of PGAM1 Protein, Human is 254 a.a., .

HY-P701963

	PGAM1 Protein, Human (His, Strep) PGAM1; phosphoglycerate mutase 1; BPG-dependent PGAM 1; phosphoglycerate mutase isozyme B; PGAM-B	Human	E. coli
	PGAM1 protein plays a pivotal role in glycolysis by catalyzing the vital interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Additionally, it is instrumental in the conversion of (2R)-2,3-bisphosphoglycerate to (2R)-3-phospho-glyceroyl phosphate, further contributing to the intricate metabolic processes associated with glycolytic pathways. PGAM1 Protein, Human (His, Strep) is the recombinant human-derived PGAM1 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of PGAM1 Protein, Human (His, Strep) is 254 a.a., .

HY-P75972

	PGK2 Protein, Human (sf9, His) phosphoglycerate kinase 2; PGK2; PGKB	Human	Sf9 insect cells
	The PGK2 protein is indispensable for sperm motility and male fertility, and studies have confirmed the critical role of the PGK2 protein in these processes. Its presence is essential to ensure the normal movement and function of sperm. PGK2 Protein, Human (sf9, His) is the recombinant human-derived PGK2 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of PGK2 Protein, Human (sf9, His) is 416 a.a., with molecular weight of ~43.5 kDa.

HY-P74633A

	PHGDH Protein, Human (C-His) D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; PGDH3	Human	E. coli
	PHGDH protein plays a key role in cellular metabolism by catalyzing the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, marking the first step in the phosphorylated L-serine biosynthetic pathway. PHGDH Protein, Human (C-His) is the recombinant human-derived PHGDH protein, expressed by E. coli , with C-6*His labeled tag. The total length of PHGDH Protein, Human (C-His) is 533 a.a., with molecular weight of ~57 kDa.


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.