2. NF-κB
  3. Keap1-Nrf2
  4. CBR-470-1

CBR-470-1 

Cat. No.: HY-134205A Purity: 98.03%
COA Handling Instructions

CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through activation of the Keap1-Nrf2 cascade.

For research use only. We do not sell to patients.

CBR-470-1 Chemical Structure

CBR-470-1 Chemical Structure

CAS No. : 2416095-06-0

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Solution
10 mM * 1 mL in DMSO USD 77 In-stock
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50 mg USD 390 In-stock
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Based on 1 publication(s) in Google Scholar

CBR-470-1 Related Antibodies

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Description

CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through activation of the Keap1-Nrf2 cascade[1][2].

IC50 & Target

Keap1-Nrf2[2]
In Vitro

CBR-470-1 (0.01-10 μM; 24 h) has an EC50 of 962 nM in ARE-LUC reporter assay of IMR32 cells[1].
CBR-470-1 (0.5-20 μM; 1-24 h) results in a dose- and time-dependent accumulation of Nrf2 protein in IMR32 cells[1].
CBR-470-1 (10 μM; 4 h) activates Nrf2 signaling cascade in SH-SY5Y cells[2].
CBR-470-1 (10 μM; 2 h) inhibits MPP+-induced oxidative injury in SH-SY5Y neuronal cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CBR-470-1 Related Antibodies

Western Blot Analysis[1]

Cell Line: IMR32 cells
Concentration: 0.5, 1, 5, 10, 20 μM
Incubation Time: 1, 2, 4, 8, 24 h
Result: Increased the Nrf2 protein in a dose- and time-dependent manner.
Increased both mRNA and protein levels of the Nrf2-responsive genes NQO1 and HMOX1.
Molecular Weight

365.90

Appearance

Solid

Formula

C14H20ClNO4S2
CAS No.
SMILES

CC(C)CN[C@H]([C@@H](S(=O)(C1=CC=C(Cl)C=C1)=O)C2)CS2(=O)=O.[Relative stereochemistry]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (546.60 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7330 mL 13.6649 mL 27.3299 mL
5 mM 0.5466 mL 2.7330 mL 5.4660 mL
10 mM 0.2733 mL 1.3665 mL 2.7330 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (13.66 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (13.66 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (13.66 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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CBR-470-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CBR-470-12416095-06-0Keap1-Nrf2glycolyticphosphoglyceratePGK1Nrf2neuronalMPP+cytotoxicity Inhibitorinhibitorinhibit

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