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Pathways Recommended:	Vitamin D Related/Nuclear Receptor

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protein kinase D (PKD)

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標的別:	PKD (4) PDK-1 (1) PKC (1)
研究分野別:	Cancer (4) Cardiovascular Disease (1) Metabolic Disease (2)

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Targets Recommended: PKD

製品番号	製品名	Target	研究分野	構造式

HY-151374

3-IN-PP1	PKD	Cancer
3-IN-PP1 is a **protein kinase D (PKD)** inhibitor. 3-IN-PP1 has potent pan-PKD inhibitory activity for PKD1, PKD2 and PKD3 with IC₅₀ values of 108, 94 and 108 nM, respectively. 3-IN-PP1 also is a broad spectrum anticancer agent and has inhibition of several tumor cells growth. 3-IN-PP1 can be used for the research of cancer .

HY-128142

PKC/PKD-IN-1	PKD PKC	Cardiovascular Disease
PKC/PKD-IN-1 (Compound 13C) is an orally active dual protein kinase C/D (PKC/PKD) inhibitor with an IC₅₀ value of 0.6 nM for *PKD1. PKC/PKD*-IN-1 can attenuate high-salt diet-induced cardiac hypertrophy and can be used in the study of heart failure .

HY-131962A

PKD-IN-1 dihydrochloride	PDK-1	Metabolic Disease Cancer
PKD-IN-1 dihydrochloride (compound 32), an aminoethylamino-aryl (AEAA) compound, acts as *PKD-1* inhibitor. PKD-IN-1 can be used for protein kinase D (PKD)-mediated diseases research .

HY-151372

Protein kinase D inhibitor 1	PKD	Cancer
Protein kinase D inhibitor 1 (compound 17m) is a pan-PKD inhibitor, with IC₅₀ values ranging from 17 to 35 nM. Protein kinase D inhibitor 1 inhibits PKD-dependent cortactin phosphorylation .

HY-131962

PKD-IN-1	PKD	Metabolic Disease Cancer
PKD-IN-1 (compound 32), an aminoethylamino-aryl (AEAA) compound, acts as *PKD-1* inhibitor. PKD-IN-1 can be used for protein kinase D (PKD)-mediated diseases research .

Species:	Human (2)
Tag:	His (1) Tag Free (1) GST (1)
Source:	sf9 insect cells (1) Sf9 insect cells (1)

製品番号	Compare	製品名	Species	Source	Image

HY-P705865

	Protein Kinase D2/PRKD2 Protein, Human (Active, sf9) Serine/threonine-protein kinase D2; PRKD2; PKD2; HSPC187	Human	sf9 insect cells

HY-P74615

	Protein Kinase D2/PRKD2 Protein, Human (Active, sf9, His-GST) Serine/threonine-protein kinase D2; PRKD2; PKD2; HSPC187	Human	Sf9 insect cells
	Protein kinase D2 (PRKD2) is a serine/threonine protein kinase that mediates various cellular processes downstream of PKC. It affects cell proliferation through MAPK1/3 (ERK1/2) signaling, activates NF-kappa-B under oxidative stress, inhibits HDAC7 transcriptional repression, and regulates T cell antigen receptor (TCR) signaling, cytokine production, Golgi trafficking, angiogenesis, particle release, and cell adhesion. Protein Kinase D2/PRKD2 Protein, Human (sf9, His-GST) is the recombinant human-derived protein Kinase D2/PRKD2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

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Host:	Rabbit (5)
Reactivity:	Human (5) Mouse (1) Rat (2)
Application:	IHC-P (1) ICC/IF (1) IP (2) WB (5) FC (1)
Isotype:	IgG (5)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (3) Recombinant (3)
Modification:	Phosphorylated (1) Unmodified (2)

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HY-P81914

	PKD1 Antibody (YA1659) PRKD1; PKD; PKD1; PRKCM; Serine/threonine-protein kinase D1; protein kinase C mu type; protein kinase D; nPKC-D1; nPKC-mu	WB	Human, Rat
	PKD1 Antibody (YA1659) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PKD1.

HY-P81914A

	PKD1 Antibody (YA1659)(PBS only) PRKD1; PKD; PKD1; PRKCM; Serine/threonine-protein kinase D1; protein kinase C mu type; protein kinase D; nPKC-D1; nPKC-mu	WB	Human, Rat
	PKD1 Antibody (YA1659) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PKD1.

HY-P81985

	PKD2 Antibody (YA1730) PRKD2; PKD2; HSPC187; Serine/threonine-protein kinase D2; nPKC-D2	WB, IHC-P, ICC/IF, FC	Human, Mouse
	PKD2 Antibody (YA1730) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PKD2.

HY-P81917

	Phospho-PRKD2 (Ser876) Antibody (YA1662) PRKD2; PKD2; HSPC187; Serine/threonine-protein kinase D2; nPKC-D2	WB, IP	Human
	Phospho-PRKD2 (Ser876) Antibody (YA1662) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PRKD2 (Ser876).

HY-P81917A

	Phospho-PRKD2 (Ser876) Antibody (YA1662)(PBS only) PRKD2; PKD2; HSPC187; Serine/threonine-protein kinase D2; nPKC-D2	WB, IP	Human
	Phospho-PRKD2 (Ser876) Antibody (YA1662) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PRKD2 (Ser876).

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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