Protein Kinase D2/PRKD2 Protein, Human (Active, sf9)

Protein Kinase D2 (PRKD2), a serine/threonine-protein kinase, acts as a pivotal mediator of diverse cellular processes. It translates transient diacylglycerol (DAG) signals into sustained physiological effects downstream of PKC, influencing cell proliferation through MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, T-cell antigen receptor (TCR) and cytokine production, Golgi membrane trafficking, angiogenesis, secretory granule release, and cell adhesion. PRKD2 may enhance mitogenesis induced by neuropeptide bombesin by prolonging MAPK1/3 signaling, leading to the accumulation of immediate-early gene products, including FOS, promoting cell cycle progression. Phosphorylation of PRKD2 at Tyr-438 and Tyr-717 by ABL1 in response to oxidative stress activates NF-kappa-B. Additionally, PRKD2, in response to gastrin receptor CCKBR activation, phosphorylates HDAC7, inhibiting its transcriptional repression of NR4A1/NUR77. The kinase also plays essential roles in T-cell activation, angiogenesis, secretion, and tumor growth, demonstrating its multifaceted involvement in cellular functions.