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Results for "

quinoline+derivative

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (3) Apoptosis (2) ATP Synthase (1) Bacterial (4) Caspase (2) DNA/RNA Synthesis (2) Drug Derivative (1) Drug Intermediate (4) Drug Isomer (1) Endogenous Metabolite (2) Environmental Pollutants (1) Fungal (3) HBV (1) Influenza Virus (1) Integrin (2) Isotope-Labeled Compounds (1) JNK (2) Mas-related G-protein-coupled Receptor (MRGPR) (1) Microtubule/Tubulin (2) Parasite (3) PDGFR (1) Platelet-activating Factor Receptor (PAFR) (1) Raf (1) Reference Standards (2)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Infection (9) Inflammation/Immunology (6) Metabolic Disease (1) Neurological Disease (3)

By Targets:

Antibiotic (3)

Apoptosis (2)

ATP Synthase (1)

Bacterial (4)

Caspase (2)

DNA/RNA Synthesis (2)

Drug Derivative (1)

Drug Intermediate (4)

Drug Isomer (1)

Endogenous Metabolite (2)

Environmental Pollutants (1)

Fungal (3)

HBV (1)

Influenza Virus (1)

Integrin (2)

Isotope-Labeled Compounds (1)

JNK (2)

Mas-related G-protein-coupled Receptor (MRGPR) (1)

Microtubule/Tubulin (2)

Parasite (3)

PDGFR (1)

Platelet-activating Factor Receptor (PAFR) (1)

Raf (1)

Reference Standards (2)

By Research Areas:

Cancer (6)

Cardiovascular Disease (1)

Infection (9)

Inflammation/Immunology (6)

Metabolic Disease (1)

Neurological Disease (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-137817

BCH001	DNA/RNA Synthesis	Metabolic Disease
BCH001, a quinoline derivative, is a specific PAPD5 inhibitor. BCH001 restores telomerase activity and telomere length in dyskeratosis congenita (DC) induced pluripotent stem cells. BCH001 shows no inhibition of poly(A)-specific ribonuclease (PARN) or several other canonical and non-canonical polynucleotide polymerases. BCH001 is used to regulate aging .

HY-W015503

4-Methylquinaldine	Drug Intermediate	Others
4-Methylquinaldine is a quinoline derivative and can be used as a drug intermediate.

HY-W004769

Benzo[h]quinoline α-Naphthoquinoline	Environmental Pollutants Drug Intermediate	Others
Benzo[h]quinolone is a widespread environmental pollutant. Benzo[h]quinolone is mutagenic. Benzo(h)quinoline derivatives can serve as G-quadruplex binding agents .

HY-59208

4-Quinolinol Kynurine	Endogenous Metabolite	Neurological Disease Cancer
4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune .

HY-W008168

Quinoline-2-carboxaldehyde 2-Quinolinecarboxaldehyde	Drug Intermediate	Others
Quinoline-2-carboxaldehyde (2-Quinolinecarboxaldehyde) is a quinoline derivative that serves as a synthetic precursor for Schiff base copper complexes. Quinoline-2-carboxaldehyde is applicable to research related to the synthetic design of biomaterials or organic compounds, such as fluorescent sensors .

HY-W012637

3-Acetylaniline 3'-Aminoacetophenone	Drug Intermediate	Others
3-Acetylaniline (3'-Aminoacetophenone) is a drug intermediate that can be used for the synthesis of quinoline derivatives .

HY-101287

MPT0B392	Microtubule/Tubulin JNK Apoptosis Caspase	Cancer
MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line .

HY-116021

Buquinolate	Parasite	Infection
Buquinolate is a quinoline derivative. Buquinolate is effective in preventing coccidiosis of chickens .

HY-152249

Antibacterial agent 131	Antibiotic Bacterial Fungal	Infection
Antibacterial agent 131 is a quinoline derivative. Antibacterial agent 131 has antimicrobial effect. Antibacterial agent 131 destroys the integrity of the fungal cells via blocking ergosterol production .

HY-172228

RPR-101511	PDGFR	Cardiovascular Disease
RPR-101511 is a 3-substituted quinoline derivative. RPR-101511 is a PDGF receptor tyrosine kinase inhibitor (IC₅₀: 0.001-0.02 μM) .

HY-121647

Nopol	Parasite	Others
Nopol is a quinoline derivative based on nopol that has inhibitory activity against the asexual blood stage of Plasmodium falciparum. Derivatives with different structures have different activities against different Plasmodium strains, and some derivatives have submicromolar EC₅₀ values in specific strains.

HY-164298

MRGPRX2 modulator-3	Mas-related G-protein-coupled Receptor (MRGPR)	Neurological Disease Inflammation/Immunology
MRGPRX2 modulator-3 (Compound 4-400) is a quinoline derivative and a MRGPRX2 modulator. MRGPRX2 modulator-3 can be used in the research of MRGPRX2-related diseases, such as allergies, pruritus, pain, inflammation and autoimmune diseases, etc .

HY-114002

Anticancer agent 129	Drug Derivative	Cancer
Anticancer agent 129 (Compound 3a), a quinoline derivative, predicting to has anti-cancer activity .

HY-105507

PF-10040	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
PF-10040 is a quinoline derivative that can inhibit PAF-induced airway hyperresponsiveness. PF-10040 also shows protective effect in experimental NSAID-gastritis .

HY-116021S

Buquinolate-13C3	Isotope-Labeled Compounds Parasite	Infection
Buquinolate-13C3 is the ¹³C₃ labeled Buquinolate. Buquinolate is a quinoline derivative, which is developed as a coccidiostat for the prevention of coccidiosis in poultry .

HY-146303

C-RAF kinase-IN-1	Raf	Cancer
C-RAF kinase-IN-1 (compound 1l) is a potent inhibitor of C-RAF kinase with an IC₅₀ of 0.193 μM. C-RAF kinase-IN-1 is a quinoline derivative. C-RAF kinase-IN-1 has the potential for the research of cancer diseases .

HY-144047

HBV-IN-16	HBV DNA/RNA Synthesis	Infection
HBV-IN-16 is a potent inhibitor of covalently closed circular DNA (cccDNA). cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-16 is a quinoline derivative. HBV-IN-16 has the potential for the research of HBV infection (extracted from patent WO2019121357A1, compound 1) .

HY-170646

Influenza A virus-IN-15	Influenza Virus	Infection
Influenza A virus-IN-15 (Compound 9b), a quinoline derivative, is a broad-spectrum inhibitor of influenza A viruses with acceptable cytotoxicity (IC₅₀: 0.88-6.33 μM). Influenza A virus-IN-15 can inhibit the transcription and replication of viral RNA and is used in research for its antiviral effects against influenza A viruses (IAV) .

HY-157045

ATP Synthesis-IN-1	ATP Synthase	Infection
ATP Synthesis-IN-1 (Compound 4), quinoline derivative, is a potent inhibitor of PA ATP synthesis activity. ATP Synthesis-IN-1 has PA ATP synthesis inhibition with IC₅₀ value of 11.1μg/mL. ATP Synthesis-IN-1 also has antibacterial activity. ATP Synthesis-IN-1 can be used for the research of drug-resistant PA infection .

HY-152137

Antituberculosis agent-7	Bacterial Fungal Antibiotic	Infection Inflammation/Immunology
Antituberculosis agent-7, an oxetanyl-quinoline derivative, has shown good antibacterial activity against P. mirabilis with a MIC of 31.25 μM. Antituberculosis agent-7 shows good antifungal activity against A. niger with a MIC of 62.5 μM. Antituberculosis agent-7 shows excellent antimycobacterial activity with MIC 3.41 μM for M. tuberculosis H37Rv .

HY-152139

Antibacterial agent 129	Bacterial Fungal Antibiotic	Infection Inflammation/Immunology
Antibacterial agent 129, an oxetanyl-quinoline derivative, has shown good antibacterial activity against P. mirabilis and B. subtilis with MICs of 31.25 μM and 31.5 μM and . Antibacterial agent 129 shows good antifungal activity against A. niger with a MIC of 31.25 μM. Antibacterial agent 129 shows excellent antimycobacterial activity with MIC 57.73 μM for M. tuberculosis H37Rv .

HY-183687

(rel)-Bedaquinoline impurity 12	Bacterial	Infection
(rel)-Bedaquinoline impurity 12 is a substituted quinoline derivative and anti-mycobacterial inhibitor. (rel)-Bedaquinoline impurity 12 can be used for the research of tuberculosis .

HY-186079

Deethyl-emvistegrast	Integrin	Inflammation/Immunology
Deethyl-emvistegrast is a quinoline derivative and also a α4β7 integrin inhibitor. Deethyl-emvistegrast is the hydrolytic product of Emvistegrast (HY-177080). Deethyl-emvistegrast modulates inflammatory pathways. Deethyl-emvistegrast can be used in research related to inflammatory bowel disease (Crohn's disease and ulcerative colitis) .

HY-59208R

4-Quinolinol (Standard) Kynurine (Standard)	Endogenous Metabolite Reference Standards	Neurological Disease Cancer
4-Quinolinol (Standard) is the analytical standard of 4-Quinolinol. This product is intended for research and analytical applications. 4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune .

HY-186079A

(S)-Deethyl-emvistegrast	Drug Isomer Integrin	Inflammation/Immunology
(S)-Deethyl-emvistegrast is the S-enantiomer of Deethyl-emvistegrast (HY-186079). Deethyl-emvistegrast is a quinoline derivative and also a α4β7 integrin inhibitor. It acts as the hydrolysis product of Emvistegrast (HY-177080). Deethyl-emvistegrast modulates inflammatory pathways and can be used in research related to inflammatory bowel diseases (Crohn's disease and ulcerative colitis) .

HY-101287R

MPT0B392 (Standard)	Microtubule/Tubulin Reference Standards JNK Apoptosis Caspase	Cancer
MPT0B392 (Standard) is the analytical standard of MPT0B392 (HY-101287). This product is intended for research and analytical applications. MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line .

Cat. No.	Product Name	Type