Benzo[h]quinoline
Based on 1 Customer Validation
Benzo[h]quinolone is a widespread environmental pollutant. Benzo[h]quinolone is mutagenic. Benzo(h)quinoline derivatives can serve as G-quadruplex binding agents.
For research use only. We do not sell to patients.
- Purity : 99.86%
- CAS No.: 230-27-3
- Formula: C13H9N
- Molecular Weight:179.22
-
Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
![Benzo[h]quinoline Chemical Structure](https://file.medchemexpress.com/product_pic/hy-w004769.gif "Click to View Benzo[h]quinoline Chemical Structure")
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-W016840
8-Hydroxyquinoline-2-carbaldehydeBiochemical Assay Reagents -
HY-Y0057
4-Quinolinecarboxylic acidEndogenous Metabolite -
HY-Y0057R
4-Quinolinecarboxylic acid (Standard)Reference Standard -
HY-Y1685
2,4-DihydroxyquinolineBiochemical Reagent -
HY-59243
4,7-DichloroquinolineQuinoline -
HY-59243R
4,7-Dichloroquinoline (Standard)Standard
Biological Activity
Description
Chemical Information
-
CAS No. 230-27-3
-
Appearance Solid
-
Molecular Weight 179.22
-
Formula C13H9N
-
SMILES
C12=CC=CN=C1C3=C(C=CC=C3)C=C2
-
Synonyms
α-Naphthoquinoline
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (557.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
-
Genotoxicity/Mutagenicity Study
The bacterial reverse mutation assay detects point mutations that restore amino-acid prototrophy in auxotrophic Salmonella typhimurium or Escherichia coli tester strains; after exposure to a test article, mutagenic activity is read out as an increased number of revertant colonies on minimal agar compared with the vehicle control. The assay uses tester strains with different mutation targets so that base-substitution and frameshift mutagens can be detected, and testing is performed with and without exogenous mammalian metabolic activation because some chemicals require biotransformation to become mutagenic.
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
[1]. LaVoie EJ, et al. Identification of the metabolites of benzo[f]quinoline and benzo[h]quinoline formed by rat liver homogenate. Carcinogenesis. 1983 Sep;4(9):1133-8. [Content Brief]
[2]. Paritala H, et al. Benzo(h)quinoline derivatives as G-quadruplex binding agents. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1584-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.5797 mL | 27.8987 mL | 55.7973 mL | 139.4934 mL |
| 5 mM | 1.1159 mL | 5.5797 mL | 11.1595 mL | 27.8987 mL | |
| 10 mM | 0.5580 mL | 2.7899 mL | 5.5797 mL | 13.9493 mL | |
| 15 mM | 0.3720 mL | 1.8599 mL | 3.7198 mL | 9.2996 mL | |
| 20 mM | 0.2790 mL | 1.3949 mL | 2.7899 mL | 6.9747 mL | |
| 25 mM | 0.2232 mL | 1.1159 mL | 2.2319 mL | 5.5797 mL | |
| 30 mM | 0.1860 mL | 0.9300 mL | 1.8599 mL | 4.6498 mL | |
| 40 mM | 0.1395 mL | 0.6975 mL | 1.3949 mL | 3.4873 mL | |
| 50 mM | 0.1116 mL | 0.5580 mL | 1.1159 mL | 2.7899 mL | |
| 60 mM | 0.0930 mL | 0.4650 mL | 0.9300 mL | 2.3249 mL | |
| 80 mM | 0.0697 mL | 0.3487 mL | 0.6975 mL | 1.7437 mL | |
| 100 mM | 0.0558 mL | 0.2790 mL | 0.5580 mL | 1.3949 mL |
Benzo[h]quinoline Related Classifications
HY-W004769 Related Classifications
Powered by Bioz