2. Anti-infection
  3. Antibiotic Bacterial Fungal
  4. Antibacterial agent 131

Antibacterial agent 131 is a quinoline derivative. Antibacterial agent 131 has antimicrobial effect. Antibacterial agent 131 destroys the integrity of the fungal cells via blocking ergosterol production.

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Antibacterial agent 131 Chemical Structure

Antibacterial agent 131 Chemical Structure

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Based on 1 publication(s) in Google Scholar

Antibacterial agent 131 Related Antibodies

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Description

Antibacterial agent 131 is a quinoline derivative. Antibacterial agent 131 has antimicrobial effect. Antibacterial agent 131 destroys the integrity of the fungal cells via blocking ergosterol production[1].

In Vitro

Antibacterial agent 131 (compound 4m) has antimicrobial activity with MIC90 values of 9.81 μg/mL for Escherichia coli ATCC 35218, E. coli ATCC 25922, Staphylococcus aureus ATCC 6538, and methicillin-resistant S. aureus (MRSA), respectively[1].
Antibacterial agent 131 has anti-candida effect with MIC90 values of ≤0.06, 0.24, 1.95, and 1.95 μg/mL for Candida krusei ATCC 6258, Candida parapsilosis ATCC 22019, Candida albicans ATCC 24433, and C. glabrata ATCC 90030, respectively[1].
Antibacterial agent 131 (24 h) has low cytotoxicity with an IC50 value of 34.51 μM in NIH/3T3 cells[1].
Antibacterial agent 131 (0.06-3.91 μg/mL) inhibits DNA-Gyrase Enzyme against E. coli[1].
Antibacterial agent 131 has antifungal activity via blocking ergosterol production[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 131 Related Antibodies
Molecular Weight

444.94

Formula

C24H17ClN4OS
Appearance

Solid

Color

Light yellow to yellow

SMILES

COC1=CC=C2N=C(C(/C=N/NC3=NC(C4=C5C=CC=CC5=CC=C4)=CS3)=CC2=C1)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (140.47 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2475 mL 11.2375 mL 22.4749 mL
5 mM 0.4495 mL 2.2475 mL 4.4950 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2475 mL 11.2375 mL 22.4749 mL 56.1874 mL
5 mM 0.4495 mL 2.2475 mL 4.4950 mL 11.2375 mL
10 mM 0.2247 mL 1.1237 mL 2.2475 mL 5.6187 mL
15 mM 0.1498 mL 0.7492 mL 1.4983 mL 3.7458 mL
20 mM 0.1124 mL 0.5619 mL 1.1237 mL 2.8094 mL
25 mM 0.0899 mL 0.4495 mL 0.8990 mL 2.2475 mL
30 mM 0.0749 mL 0.3746 mL 0.7492 mL 1.8729 mL
40 mM 0.0562 mL 0.2809 mL 0.5619 mL 1.4047 mL
50 mM 0.0449 mL 0.2247 mL 0.4495 mL 1.1237 mL
60 mM 0.0375 mL 0.1873 mL 0.3746 mL 0.9365 mL
80 mM 0.0281 mL 0.1405 mL 0.2809 mL 0.7023 mL
100 mM 0.0225 mL 0.1124 mL 0.2247 mL 0.5619 mL
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Antibacterial agent 131 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 131Antibacterial agent131Antibacterial agent-131AntibioticBacterialFungalanticandidalC. parapsilosisC. kruseiaromatase enzymeNIH/3T3Inhibitorinhibitorinhibit

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