Antibacterial agent 131
Based on 1 Customer Validation
Antibacterial agent 131 is a quinoline derivative. Antibacterial agent 131 has antimicrobial effect. Antibacterial agent 131 destroys the integrity of the fungal cells via blocking ergosterol production.
For research use only. We do not sell to patients.
- Purity: 98.52%
- CAS No.: 3026790-18-8
- Formula: C24H17ClN4OS
- Molecular Weight:444.94
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Antibacterial agent 131 (compound 4m) has antimicrobial activity with MIC90 values of 9.81 μg/mL for Escherichia coli ATCC 35218, E. coli ATCC 25922, Staphylococcus aureus ATCC 6538, and methicillin-resistant S. aureus (MRSA), respectively[1].
Antibacterial agent 131 has anti-candida effect with MIC90 values of ≤0.06, 0.24, 1.95, and 1.95 μg/mL for Candida krusei ATCC 6258, Candida parapsilosis ATCC 22019, Candida albicans ATCC 24433, and C. glabrata ATCC 90030, respectively[1].
Antibacterial agent 131 (24 h) has low cytotoxicity with an IC50 value of 34.51 μM in NIH/3T3 cells[1].
Antibacterial agent 131 (0.06-3.91 μg/mL) inhibits DNA-Gyrase Enzyme against E. coli[1].
Antibacterial agent 131 has antifungal activity via blocking ergosterol production[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3026790-18-8
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Appearance Solid
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Molecular Weight 444.94
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Formula C24H17ClN4OS
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Color Light yellow to yellow
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SMILES
COC1=CC=C2N=C(C(/C=N/NC3=NC(C4=C5C=CC=CC5=CC=C4)=CS3)=CC2=C1)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 62.5 mg/mL (140.47 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2475 mL | 11.2375 mL | 22.4749 mL | 56.1874 mL |
| 5 mM | 0.4495 mL | 2.2475 mL | 4.4950 mL | 11.2375 mL | |
| 10 mM | 0.2247 mL | 1.1237 mL | 2.2475 mL | 5.6187 mL | |
| 15 mM | 0.1498 mL | 0.7492 mL | 1.4983 mL | 3.7458 mL | |
| 20 mM | 0.1124 mL | 0.5619 mL | 1.1237 mL | 2.8094 mL | |
| 25 mM | 0.0899 mL | 0.4495 mL | 0.8990 mL | 2.2475 mL | |
| 30 mM | 0.0749 mL | 0.3746 mL | 0.7492 mL | 1.8729 mL | |
| 40 mM | 0.0562 mL | 0.2809 mL | 0.5619 mL | 1.4047 mL | |
| 50 mM | 0.0449 mL | 0.2247 mL | 0.4495 mL | 1.1237 mL | |
| 60 mM | 0.0375 mL | 0.1873 mL | 0.3746 mL | 0.9365 mL | |
| 80 mM | 0.0281 mL | 0.1405 mL | 0.2809 mL | 0.7023 mL | |
| 100 mM | 0.0225 mL | 0.1124 mL | 0.2247 mL | 0.5619 mL |
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