taxanes

By Targets:	Antibody-Drug Conjugates (ADCs) (1) Apoptosis (2) Aurora Kinase (1) CD276/B7-H3 (1) HIF/HIF Prolyl-Hydroxylase (1) Microtubule/Tubulin (2)
By Research Areas:	Cancer (10) Metabolic Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7483

1-Dehydroxybaccatin IV	Others	Metabolic Disease
1-Dehydroxybaccatin IV is a taxane diterpene. 1-Dehydroxybaccatin IV shows concentration-dependent NO inhibition, with an IC₅₀ of 32.2 μM .

HY-133194

Taxinine M

Others Others

Taxinine M, a tetracyclic taxane, can be isolated from Taxus brevifolia .
HY-N8070

13-O-Cinnamoylbaccatin III

Baccatin III 13-cinnamate
Others Others

13-O-Cinnamoylbaccatin III (Baccatin III 13-cinnamate) is a taxane that can be found in the twigs of Taxus mairei .

Taxinine M	Others	Others
Taxinine M, a tetracyclic taxane, can be isolated from Taxus brevifolia .

13-O-Cinnamoylbaccatin III Baccatin III 13-cinnamate	Others	Others
13-O-Cinnamoylbaccatin III (Baccatin III 13-cinnamate) is a taxane that can be found in the twigs of Taxus mairei .

HY-W778562

10-Deacetyl-13-oxobaccatin III	Others	Cancer
10-Deacetyl-13-oxobaccatin III is an taxane that can be isolated from Taxus sumatrana. 10-Deacetyl-13-oxobaccatin III (30 μg/mL) shows cytotoxicity against A498, NCI-H226, A549, PC-3 cells, with inhibition a rate of 29.7%, 49.2%, 43.9%, 65.3% .

HY-N7366

Taxachitriene A

Others Others

Taxachitriene A is a bicyclic taxane diterpenoid that can be found in the needles of Taxus chinensis .
HY-126655

Yunnanxane

Others Others

Yunnanxane (compound 1) is a taxane diterpenoid that can be found in Taxus chinensis var. .
HY-N9043

Tasumatrol L

Others Others

Tasumatrol L (compound 5) is a 21-carbon taxane ester that can be found in Taxus sumatrana .
HY-N1173

Taxayuntin

Taxayunnansin A; 13-Decinnamoyltaxchinin B

Taxayuntin (Taxayunnansin A; 13-Decinnamoyltaxchinin B) is a taxane diterpenoid isolated from Taxus yunnanensis .

Taxachitriene A	Others	Others
Taxachitriene A is a bicyclic taxane diterpenoid that can be found in the needles of Taxus chinensis .

Yunnanxane	Others	Others
Yunnanxane (compound 1) is a taxane diterpenoid that can be found in Taxus chinensis var. .

Tasumatrol L	Others	Others
Tasumatrol L (compound 5) is a 21-carbon taxane ester that can be found in Taxus sumatrana .

Taxayuntin Taxayunnansin A; 13-Decinnamoyltaxchinin B
Taxayuntin (Taxayunnansin A; 13-Decinnamoyltaxchinin B) is a taxane diterpenoid isolated from Taxus yunnanensis .

HY-16491

Tesetaxel DJ-927	Microtubule/Tubulin	Cancer
Tesetaxel is a orally active, semisynthetic microtubule inhibitor of the taxane class for the research of cancer, including colorectal and gastric cancer.

HY-N9168

Baccatin IV

Others Others

Baccatin IV is a taxane diterpenoid. Baccatin IV can be isolated and identified from the root bark of Taxus mairei .

Baccatin IV	Others	Others
Baccatin IV is a taxane diterpenoid. Baccatin IV can be isolated and identified from the root bark of Taxus mairei .

HY-125374

Larotaxel XRP9881	Apoptosis	Cancer
Larotaxel (XRP9881) is a taxane analogue with preclinical activity against taxane-resistant breast cancer. Larotaxel (XRP9881) exerts its cytotoxic effect by promoting tubulin assembly and stabilizing microtubules, ultimately leading to cell death by apoptosis. It presents the ability to cross the blood brain barrier and has a much lower affinity for P-glycoprotein 1 than Docetaxel .

HY-125374A

Larotaxel dihydrate XRP9881 dihydrate	Others	Cancer
Larotaxel (dihydrate) (XRP9881 (dihydrate)), a new taxane compound prepared by partial synthesis from 10-deacetyl baccatin III, is active against tumors .

HY-121524

DJ101	Microtubule/Tubulin	Cancer
DJ101 is a potent and metabolically stable tubulin inhibitor. DJ101 targets the colchicine binding site and overcomes taxane resistance. DJ101 also inhibits melanoma tumor growth and lung metastasis. DJ101 can be used for prostate cancer research .

HY-137377

TAS-119	Aurora Kinase	Cancer
TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC₅₀ of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC₅₀ of 95 nM). TAS-119 has potent antitumor activites .

HY-N1391

10-Deacetyltaxol 10-Deacetylpaclitaxel
10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

HY-P4073

ANG1005 GRN1005; Paclitaxel trevatide	Antibody-Drug Conjugates (ADCs)	Cancer
ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system .

HY-P99740

Mirzotamab	CD276/B7-H3	Cancer
Mirzotamab is an IgG1κ antibody targeting to CD276/B7-H3. Mirzotamab can conjugates with Clezutoclax (HY-137774), an BCL inhibitor to form Mirzotamab clezutoclax (HY-P99741), involving in research with taxane research in relapsed/refractory solid tumors. Mirzotamab clezutoclax (ABBV-155) is a targeted antibody drug conjugate (ADC) .

HY-16187

EL-102	HIF/HIF Prolyl-Hydroxylase Apoptosis	Cancer
EL-102 is a hypoxia-induced factor 1 (Hif1α) inhibitor. EL-102 induces apoptosis, inhibits tubulin polymerisation and shows activities against prostate cancer. EL-102 can be used for the research of cancer .

HY-N12004

19-Hydroxy-10-deacetylbaccatin III	Others	Cancer
19-Hydroxy-10-deacetylbaccatin III (compound 13) is a taxane with potential antitumor activity. 19-Hydroxy-10-deacetylbaccatin III has weak cytotoxicity against A498 and NCI-H226 cell lines. The study found that the inhibition rates of 30 μg/mL 19-Hydroxy-10-deacetylbaccatin III on A498, NCI-H226 and PC-3 were 16.6% and 32% respectively .

Cat. No.	Product Name	Target	Research Area

HY-P4073

ANG1005 GRN1005; Paclitaxel trevatide	Antibody-Drug Conjugates (ADCs)	Cancer
ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system .

Cat. No.	Product Name	Target	Research Area

HY-P99740

Mirzotamab	CD276/B7-H3	Cancer
Mirzotamab is an IgG1κ antibody targeting to CD276/B7-H3. Mirzotamab can conjugates with Clezutoclax (HY-137774), an BCL inhibitor to form Mirzotamab clezutoclax (HY-P99741), involving in research with taxane research in relapsed/refractory solid tumors. Mirzotamab clezutoclax (ABBV-155) is a targeted antibody drug conjugate (ADC) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7483

1-Dehydroxybaccatin IV	Structural Classification Natural Products Classification of Application Fields Source classification Taxaceae Metabolic Disease Taxus yunnanensis W.C.Cheng & L.K.Fu Plants Disease Research Fields	Others
1-Dehydroxybaccatin IV is a taxane diterpene. 1-Dehydroxybaccatin IV shows concentration-dependent NO inhibition, with an IC₅₀ of 32.2 μM .

HY-133194

Taxinine M	Structural Classification Natural Products Taxus cuspidata Siebold & Zucc. Source classification Taxaceae Plants	Others
Taxinine M, a tetracyclic taxane, can be isolated from Taxus brevifolia .

HY-W778562

10-Deacetyl-13-oxobaccatin III	Structural Classification Terpenoids Source classification Taxaceae Diterpenoids Plants Taxus baccata L.	Others
10-Deacetyl-13-oxobaccatin III is an taxane that can be isolated from Taxus sumatrana. 10-Deacetyl-13-oxobaccatin III (30 μg/mL) shows cytotoxicity against A498, NCI-H226, A549, PC-3 cells, with inhibition a rate of 29.7%, 49.2%, 43.9%, 65.3% .

HY-N7366

Taxachitriene A	Structural Classification Ketones, Aldehydes, Acids Source classification Taxaceae Plants Taxus chinensis (Pilger) Rehd.	Others
Taxachitriene A is a bicyclic taxane diterpenoid that can be found in the needles of Taxus chinensis .

HY-126655

Yunnanxane	Structural Classification Terpenoids Source classification Taxaceae Diterpenoids Taxus yunnanensis W.C.Cheng & L.K.Fu Plants	Others
Yunnanxane (compound 1) is a taxane diterpenoid that can be found in Taxus chinensis var. .

HY-N9043

Tasumatrol L	Structural Classification Ketones, Aldehydes, Acids Source classification Taxaceae Taxus sumatrana (Miq.) de Laub. Plants	Others
Tasumatrol L (compound 5) is a 21-carbon taxane ester that can be found in Taxus sumatrana .

HY-N9168

Baccatin IV	Structural Classification Ketones, Aldehydes, Acids Source classification Taxaceae Plants Taxus chinensis (Pilger) Rehd.	Others
Baccatin IV is a taxane diterpenoid. Baccatin IV can be isolated and identified from the root bark of Taxus mairei .

HY-N12004

19-Hydroxy-10-deacetylbaccatin III	Structural Classification Terpenoids Source classification Taxaceae Diterpenoids Plants Taxus chinensis (Pilger) Rehd.	Others
19-Hydroxy-10-deacetylbaccatin III (compound 13) is a taxane with potential antitumor activity. 19-Hydroxy-10-deacetylbaccatin III has weak cytotoxicity against A498 and NCI-H226 cell lines. The study found that the inhibition rates of 30 μg/mL 19-Hydroxy-10-deacetylbaccatin III on A498, NCI-H226 and PC-3 were 16.6% and 32% respectively .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Name
Email *

	Sorry, but the email address you supplied was invalid.

taxanes

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

NaturalProducts

Natural
Products