1. Metabolic Enzyme/Protease
    Apoptosis
  2. HIF/HIF Prolyl-Hydroxylase
    Apoptosis
  3. EL-102

EL-102 

Cat. No.: HY-16187 Purity: 99.76%
COA Handling Instructions

EL-102 is a hypoxia-induced factor 1 (Hif1α) inhibitor. EL-102 induces apoptosis, inhibits tubulin polymerisation and shows activities against prostate cancer. EL-102 can be used for the research of cancer.

For research use only. We do not sell to patients.

EL-102 Chemical Structure

EL-102 Chemical Structure

CAS No. : 1233948-61-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 237 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 237 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 280 In-stock
Estimated Time of Arrival: December 31
10 mg USD 448 In-stock
Estimated Time of Arrival: December 31
50 mg USD 940 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1410 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

EL-102 is a hypoxia-induced factor 1 (Hif1α) inhibitor. EL-102 induces apoptosis, inhibits tubulin polymerisation and shows activities against prostate cancer. EL-102 can be used for the research of cancer[1].

IC50 & Target

IC50: 24 nM (CWR22), 21.7 nM (22Rv1), 40.3 nM (DU145), 37.0 nM (PC-3), 14.4 nM (DLKP), 16.3 nM (DLKPA)[1]

In Vitro

EL-102 (0-120 nM; 72 h) inhibits prostate cancer cells proliferation in vitro[1].
EL-102 (0-100 nM; 72 h) shows cytotoxicity to prostate cancer cell lines[1].
EL-102 (10-100 nM; 24-72 h) induces cellular apoptosis and affects cell cycle[1].
EL-102 (10-100 nM; 24-48 h) affects PARP cleavage in DU145 cells[1].
EL-102 (5 nM; 0-60 min) inhibits tubulin polymerisation activity[1].
EL-102 (0-100 nM; 1 hour) inhibits Hif1α protein expression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: CWR22, 22Rv1, DU145, PC-3, DLKP and DLKPA cell lines
Concentration: 0-120 nM
Incubation Time: 72 hours
Result: Inhibited proliferation of CWR22, 22Rv1, DU145, PC-3, DLKP and doxorubicin-selected variant DLKPA cells with IC50s of 24, 21.7, 40.3, 37.0, 14.4 and 16.3 nM, respectively.

Cell Cytotoxicity Assay[1]

Cell Line: CWR22, 22Rv1, DU145 and PC-3 cell lines
Concentration: 0-100 nM
Incubation Time: 72 hours
Result: Exibited cytotoxicity to prostate cancer cell lines, and showed no additive effect on the inhibition of cell viability with docetaxel.

Apoptosis Analysis[1]

Cell Line: CWR22, 22Rv1, DU145, PC-3, DLKP and DLKPA cell lines
Concentration: 10 and 100 nM
Incubation Time: 24, 48 and 72 hours
Result: Induced cell apoptosis to inhibits cell viability with a dose of 100 nM.

Western Blot Analysis[1]

Cell Line: DU145 cell line
Concentration: 10 and 100 nM
Incubation Time: 24 and 48 hours
Result: Increased PARP cleavage in DU145 cells and showed a more dramatic effect with docetaxel adding.

Cell Cycle Analysis[1]

Cell Line: DU145 cell line
Concentration: 10 and 100 nM
Incubation Time: 24, 48 and 72 hours
Result: Increased loss of cells from G1 phase and accumulated cells in G2/M phase.

Western Blot Analysis[1]

Cell Line: Prostate cancer cells
Concentration: 10 , 50 and 100 nM
Incubation Time: 24 and 48 hours
Result: Modestly inhibited Hif1α expression at doses of 50 and 100 nM in normoxia.
In Vivo

EL-102 (12 and 15 mg/kg; p.o. 5-day on and 2-day off, from 13 to 37 days after tumour transplantation) potentiates effects of docetaxel in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice with CWR22 xenografts[1]
Dosage: 12 and 15 mg/kg
Administration: Oral gavage; 12 and 15 mg/kg 5-day on and 2-day off; from 13 to 37 days after tumour transplantation
Result: Showed no effect on tumor growth, but enhanced the effect of docetaxel on tumor .
Molecular Weight

384.47

Formula

C19H16N2O3S2

CAS No.
SMILES

O=S(C1=CC=C(OC)C=C1)(NC2=CC(C3=CSC(C#N)=C3)=CC=C2C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 36 mg/mL (93.64 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6010 mL 13.0049 mL 26.0098 mL
5 mM 0.5202 mL 2.6010 mL 5.2020 mL
10 mM 0.2601 mL 1.3005 mL 2.6010 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
EL-102
Cat. No.:
HY-16187
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