1. Apoptosis
  2. Apoptosis
  3. Larotaxel

Larotaxel (Synonyms: XRP9881)

Cat. No.: HY-125374 Purity: 98.62%
Handling Instructions

Larotaxel (XRP9881) is a taxane analogue with preclinical activity against taxane-resistant breast cancer. Larotaxel (XRP9881) exerts its cytotoxic effect by promoting tubulin assembly and stabilizing microtubules, ultimately leading to cell death by apoptosis. It presents the ability to cross the blood brain barrier and has a much lower affinity for P-glycoprotein 1 than Docetaxel.

For research use only. We do not sell to patients.

Larotaxel Chemical Structure

Larotaxel Chemical Structure

CAS No. : 156294-36-9

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1 mg USD 160 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Larotaxel (XRP9881) is a taxane analogue with preclinical activity against taxane-resistant breast cancer. Larotaxel (XRP9881) exerts its cytotoxic effect by promoting tubulin assembly and stabilizing microtubules, ultimately leading to cell death by apoptosis. It presents the ability to cross the blood brain barrier and has a much lower affinity for P-glycoprotein 1 than Docetaxel[1][2][3].

Molecular Weight

831.90

Formula

C₄₅H₅₃NO₁₄

CAS No.

156294-36-9

SMILES

O=C([[email protected]]1([H])OC(C)=O)[[email protected]@]23[[email protected]@]([[email protected]@H]([[email protected]@]4(O)C(C)(C)C1=C([[email protected]](OC([[email protected]](O)[[email protected]](C5=CC=CC=C5)NC(OC(C)(C)C)=O)=O)C4)C)OC(C6=CC=CC=C6)=O)([H])[[email protected]]7([[email protected]@](OC7)([H])C[[email protected]@H]2C3)OC(C)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (60.10 mM)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2021 mL 6.0103 mL 12.0207 mL
5 mM 0.2404 mL 1.2021 mL 2.4041 mL
10 mM 0.1202 mL 0.6010 mL 1.2021 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Larotaxel
Cat. No.:
HY-125374
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