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Cat. No.: HY-125374S

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Larotaxel-d₉

Name: Larotaxel-d9
Brand: MedChemExpress
SKU: HY-125374S
Availability: PreOrder

(Synonyms: XRP9881-d₉)

Larotaxel-d₉ (XRP9881-d₉) is the d₉-labeled Larotaxel (HY-125374). Larotaxel (XRP9881) is an orally active and blood-brain barrier penetrant Microtubule stabilizer with an IC₅₀ of 0.21 μM. Larotaxel shows activity in Taxane-resistant tumor models. Larotaxel exhibits antitumor activity in intracranial glioblastoma models. Larotaxel can be used for research on advanced solid tumors.

For research use only. We do not sell to patients.

Formula: C₄₅H₄₄D₉NO₁₄
Molecular Weight:840.96

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Please store the product under the recommended conditions in the Certificate of Analysis.

Larotaxel-d₉ Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled CAS 156294-36-9
Molecular Weight 840.96
Formula C₄₅H₄₄D₉NO₁₄
SMILES

O=C([C@]1([H])OC(C)=O)[C@@]23[C@@]([C@@H]([C@@]4(O)C(C)(C)C1=C([C@H](OC([C@H](O)[C@H](C5=CC=CC=C5)NC(OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=O)C4)C)OC(C6=CC=CC=C6)=O)([H])[C@]7([C@@](OC7)([H])C[C@@H]2C3)OC(C)=O
Synonyms

XRP9881-d₉
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yamamoto N, et al. Phase I study of larotaxel administered as a 1-h intravenous infusion every 3 weeks to Japanese patients with advanced solid tumours. Cancer chemotherapy and pharmacology. 2009 Dec;65(1):129-36.

[2]. Men L, et al. Metabolism of TM-2, a potential antitumor drug, in rats by using LC-MS. Journal of separation science. 2014 Mar;37(6):625-9.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Larotaxel-d9

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