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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
45 Results for "
tumor vasculature
" in MedChemExpress (MCE) Product Catalog:
Products (45)
45 Results for "tumor vasculature" in MCE Product Catalog:
59
59 Publications Verification
Synonyms: XL184; BMS-907351
Target:
Research Areas:
Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis .
2
2 Cited Publications
Cat. No.: HY-P99279
CAS No.: 648904-28-3
Synonyms: Anti-Human Phosphatidylserine Recombinant Antibody; PGN-401; CH3G4
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2
2 Cited Publications
Target:
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L748337 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The Ki values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively . L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6 . L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases .
Cat. No.: HY-P991097
Synonyms: PM-8002; BNT-327
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Cat. No.: HY-P10709A
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Cat. No.: HY-13016R
CAS No.: 849217-68-1
Synonyms: XL184 (Standard); BMS-907351 (Standard)
Research Areas:
Cabozantinib (Standard) is the analytical standard of Cabozantinib. This product is intended for research and analytical applications. Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis .
Cat. No.: HY-161248
Target:
Research Areas:
E7130 is a microtubule inhibitor, which ameliorates the tumor microenvironment through suppression of cancer-associated fibroblasts (CAF) and promotion of tumor vasculature remodeling .
Cat. No.: HY-13016A
CAS No.: 1817759-42-4
Synonyms: XL184 hydrochloride; BMS-907351 hydrochloride
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Cabozantinib hydrochloride is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035 and 1.3 nM, respectively. Cabozantinib hydrochloride displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib hydrochloride shows antiangiogenic activity. Cabozantinib hydrochloride disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis .
Cat. No.: HY-175323
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Cat. No.: HY-P991330
Cat. No.: HY-172497
DSPE-PEG2000-CREKA is a PEG compound which composed of DSPE and a fibrin-targeting peptide (CREKA). CREKA peptide can be used to target tumor cells and tumor vasculature, exhibiting antitumor activity. DSPE-PEG2000-CREKA can be used for drug delivery .
Cat. No.: HY-116135
CAS No.: 151417-66-2
Research Areas:
R24 is a type of flavonoid derivative. R24 exhibits strong anti-angiogenic and anti-proliferative effects. R24 induces cell apoptosis and promotes the production of reactive oxygen species (ROS). R24 can be used for the study of cancers such as lung cancer and colorectal cancer .
Cat. No.: HY-P991384
Cat. No.: HY-P10770
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Cat. No.: HY-P10705
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Cat. No.: HY-172496
DSPE-PEG1000-CREKA is a PEG compound which composed of DSPE and a fibrin-targeting peptide (CREKA). CREKA peptide can be used to target tumor cells and tumor vasculature, exhibiting antitumor activity. DSPE-PEG1000-CREKA can be used for drug delivery .
Cat. No.: HY-172497A
DSPE-PEG3400-CREKA is a PEG compound which composed of DSPE and a fibrin-targeting peptide (CREKA). CREKA peptide can be used to target tumor cells and tumor vasculature, exhibiting antitumor activity. DSPE-PEG3400-CREKA can be used for drug delivery .
Cat. No.: HY-172498
DSPE-PEG5000-CREKA is a PEG compound which composed of DSPE and a fibrin-targeting peptide (CREKA). CREKA peptide can be used to target tumor cells and tumor vasculature, exhibiting antitumor activity. DSPE-PEG5000-CREKA can be used for drug delivery .
Cat. No.: HY-187399A
Synonyms: DOPE-PEG2000-Mal-Cys-NGR
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DOPE-PEG2000-NGR (DOPE-PEG2000-Mal-Cys-NGR) is an amphiphilic lipid-PEG-peptide conjugate composed of DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine), PEG2000, and the NGR (Asn-Gly-Arg) peptide, a tumor-homing tripeptide motif. NGR peptide specifically binds to aminopeptidase N (CD13) that is overexpressed on angiogenic tumor vasculature. DOPE-PEG2000-NGR is used for tumor vasculature-targeted drug delivery and anti-angiogenic research.
Cat. No.: HY-187415A
Synonyms: DOPE-PEG2000-Mal-Cys-TAASGVRSMH
Target:
Research Areas:
DOPE-PEG2000-TAASGVRSMH is an amphiphilic lipid-PEG-peptide conjugate composed of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) , polyethylene glycol 2000 (PEG2000) , and the TAASGVRSMH peptide.
DOPE provides a hydrophobic phospholipid anchor for membrane insertion, PEG2000 forms a hydrophilic spacer that enhances circulation stability, and the TAASGVRSMH peptide serves as a tumor-vasculature-homing ligand identified by in vivo phage display.
This conjugate can be used to functionalize liposomes and lipid nanoparticles for targeted drug delivery to tumor vasculature.
DOPE provides a hydrophobic phospholipid anchor for membrane insertion, PEG2000 forms a hydrophilic spacer that enhances circulation stability, and the TAASGVRSMH peptide serves as a tumor-vasculature-homing ligand identified by in vivo phage display.
This conjugate can be used to functionalize liposomes and lipid nanoparticles for targeted drug delivery to tumor vasculature.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
