1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. L748337

L748337 

Cat. No.: HY-103211 Purity: 96.41%
Handling Instructions

L748337 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The Ki values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively. L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6. L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases.

For research use only. We do not sell to patients.

L748337 Chemical Structure

L748337 Chemical Structure

CAS No. : 244192-94-7

Size Price Stock Quantity
5 mg USD 530 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

L748337 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The Ki values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively[1]. L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6[2]. L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases[1][2][3].

IC50 & Target[1]

Beta-3 adrenergic receptor

4 nM (Ki)

Beta-2 adrenergic receptor

204 nM (Ki)

Beta-1 adrenergic receptor

390 nM (Ki)

In Vitro

L748337 (1 μM) inhibits iNOS expression in B16F10 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

L-748337 (intraperitoneal injection; 5 mg/kg; beginning 10 days until D18) decreases the growth of melanoma induced by B16F10 cell inoculation and decreases tumor vasculature in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fifty male C57BL/6 J mice (8 weeks of age) bearing syngeneic B16F10 cell[1]
Dosage: 5 mg/kg
Administration: Beginning 10 days until D18
Result: Exhibited anti-cancer effects.
Molecular Weight

497.61

Formula

C₂₆H₃₁N₃O₅S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

Ethanol : 30 mg/mL (60.29 mM; Need ultrasonic and warming)

DMSO : 25 mg/mL (50.24 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0096 mL 10.0480 mL 20.0961 mL
5 mM 0.4019 mL 2.0096 mL 4.0192 mL
10 mM 0.2010 mL 1.0048 mL 2.0096 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.02%

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L748337
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HY-103211
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