2. Metabolic Enzyme/Protease
  3. PEPCK
  4. SKF-34288 hydrochloride

SKF-34288 hydrochloride  (Synonyms: 3-Mercaptopicolinic acid hydrochloride; 3-MPA hydrochloride)

Art. -Nr.: HY-128923 Reinheit: 98.61%
COA
SDS
Handling Instructions Technical Support

SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor (Ki: 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides.

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SKF-34288 hydrochloride

SKF-34288 hydrochloride Chemische Struktur

CAS. Nr. : 320386-54-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Solution
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Based on 8 publication(s) in Google Scholar

SKF-34288 hydrochloride Related Antibodies

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Beschreibung

SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor (Ki: 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides[1][2].

IC50 & Target

Ki: 2-9 μM (PEPCK)[1]
In Vitro

SKF-34288 hydrochloride (0.01-1 mM, 48 h) inhibits C2C12 cell proliferation[4].
SKF-34288 hydrochloride (0.25-1 mM, 0-5 day) induces myogenic differentiation of C2C12 cells[4].
SKF-34288 hydrochloride (0.25 or 1 mM) reduces mRNA expression of Pck2 and genes associated with serine biosynthesis[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SKF-34288 hydrochloride Related Antibodies

Cell Viability Assay[4]

Cell Line: C2C12 cell
Concentration: 0, 0.01, 0.1, 0.25, 0.5, 1 mM
Incubation Time: 48 h
Result: Dose-dependently inhibited C2C12 cell proliferation.
In Vivo

SKF-34288 hydrochloride (37.5-150mg/kg, p.o.) reduces blood glucose in starved rats[6].
SKF-34288 hydrochloride (25 mg/kg, s.c.) neutralizes Salbutamol- mediated hyperglycaemia in rabbits[3].
SKF-34288 hydrochloride (30 and 300 mg/kg, i.p.) reduces Pyruvate-induced blood glucose level in rats[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Starved rats[6]
Dosage: 37.5, 75 and 150mg/kg
Administration: Oral administration (p.o.)
Result: Showed dose-dependent magnitude and duration of the hypoglycaemic effect.
Molekulargewicht

191.64

Formel

C6H6ClNO2S
CAS. Nr.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=NC=CC=C1S)O.[H]Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit
In Vitro: 

H2O : 5 mg/mL (26.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2181 mL 26.0906 mL 52.1812 mL
5 mM 1.0436 mL 5.2181 mL 10.4362 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 3.33 mg/mL (17.38 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Reinheit & Dokumentation

Purity: 98.61%

SDS (393 KB)

COA (246 KB) HNMR (240 KB) RP-HPLC (248 KB) MS (228 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.2181 mL 26.0906 mL 52.1812 mL 130.4529 mL
5 mM 1.0436 mL 5.2181 mL 10.4362 mL 26.0906 mL
10 mM 0.5218 mL 2.6091 mL 5.2181 mL 13.0453 mL
15 mM 0.3479 mL 1.7394 mL 3.4787 mL 8.6969 mL
20 mM 0.2609 mL 1.3045 mL 2.6091 mL 6.5226 mL
25 mM 0.2087 mL 1.0436 mL 2.0872 mL 5.2181 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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SKF-34288 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKF-34288320386-54-73-Mercaptopicolinic acid3-MPASKF34288SKF 34288PEPCKPhosphoenolpyruvate CarboxykinaseC2C12glucose synthesishypoglycemicblood glucoseInhibitorinhibitorinhibit

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