320386-54-7
320386-54-7
Chemical Structure
SKF-34288 hydrochloride
Synonym(s): 3-Mercaptopicolinic acid hydrochloride; 3-MPA hydrochloride
- CAS No.: 320386-54-7
- Formula:C6H6ClNO2S
- Molecular Weight:191.64
IUPAC Name: 3-mercaptopicolinic acid hydrochloride
InChIKey: DYGYEUUVNLEHJP-UHFFFAOYSA-N
SMILES: O=C(C1=NC=CC=C1S)O.[H]Cl
Biological Activity: SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor (Ki: 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides[1][2].
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SKF-34288 hydrochloride | 98.61% | SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor (Ki: 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides. | ||||||||||||||||||||
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References
- [1]. Balan MD, et al. Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid. Biochemistry. 2015 Sep 29;54(38):5878-87. [Content Brief]
- [2]. Bailey KJ, et al. Nitrogen recycling from the xylem in rice leaves: dependence upon metabolism and associated changes in xylem hydraulics. J Exp Bot. 2016 Apr;67(9):2901-11. [Content Brief]
