Art. -Nr.: HY-Y0030

3-Hydroxypicolinic acid

Name: 3-Hydroxypicolinic acid
Brand: MedChemExpress
SKU: HY-Y0030
Price: 30.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: 3-hydroxypyridine-2-carboxylic acid)

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3-Hydroxypicolinic acid is a heterocyclic carboxylic acid ligand and cytotoxin, with a MIC₉₀ of >25 μg/mL against Mycobacterium tuberculosis H37Rv. 3-Hydroxypicolinic acid inhibits the growth of cancer cells and normal fibroblasts. 3-Hydroxypicolinic acid is applicable to research related to chronic myeloid leukemia, human lung adenocarcinoma, and tuberculosis.

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Reinheit: 99.92%
CAS. Nr.: 874-24-8
Formel: C₆H₅NO₃
Molecular Weight:139.11

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

3-Hydroxypicolinic acid Chemical Structure

CAS. Nr.: 874-24-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

3-Hydroxypicolinic acid (72 h) inhibits K562 chronic myelogenous leukemia cell proliferation with an IC₅₀ of 130.0 μM following 72 h of incubation^[1].
3-Hydroxypicolinic acid (24-72 h) inhibits MRC-5 normal pulmonary fibroblast cell proliferation with IC₅₀ values of 2767.6 μM (72 h incubation) and 2228.4 μM (24 h incubation)^[1].
3-Hydroxypicolinic acid (24 h) inhibits A549 human lung adenocarcinoma epithelial cell proliferation with an IC₅₀ of 2264.4 μM following 24 h of incubation^[1].
3-Hydroxypicolinic acid (7 days) does not inhibit Mycobacterium tuberculosis H37Rv growth at concentrations up to 179.7 μM following 7 days of incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

K562 chronic myelogenous leukemia cells
Concentration:

130.0 μM
Incubation Time:

72 h
Result:

Inhibited 50% of K562 cell proliferation at a concentration of 130.0 μM after 72 h of incubation.

Cell Cytotoxicity Assay^[1]

Cell Line:

MRC-5 normal pulmonary fibroblast cells
Concentration:

2767.6 μM (72 h incubation); 2228.4 μM (24 h incubation)
Incubation Time:

72 h, 24 h
Result:

Inhibited 50% of MRC-5 cell proliferation at a concentration of 2767.6 μM after 72 h of incubation.
Inhibited 50% of MRC-5 cell proliferation at a concentration of 2228.4 μM after 24 h of incubation.

Cell Cytotoxicity Assay^[1]

Cell Line:

A549 human lung adenocarcinoma epithelial cells
Concentration:

2264.4 μM
Incubation Time:

24 h
Result:

Inhibited 50% of A549 cell proliferation at a concentration of 2264.4 μM after 24 h of incubation.

Chemical Information

CAS. Nr. 874-24-8
Appearance Solid
Molecular Weight 139.11
Formel C₆H₅NO₃
Color White to light yellow
SMILES

O=C(C1=NC=CC=C1O)O
Synonyms

3-hydroxypyridine-2-carboxylic acid
Structure Classification
- Phenols
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (359.43 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

7.1886 mL

35.9428 mL

71.8856 mL

5 mM

1.4377 mL

7.1886 mL

14.3771 mL

10 mM

0.7189 mL

3.5943 mL

7.1886 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 1.25 mg/mL (8.99 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 1.25 mg/mL (8.99 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1.25 mg/mL (8.99 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (291 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Janaina do Couto Almeida, et al. Synthesis, cytotoxic and antitubercular activities of copper(II) complexes with heterocyclic bases and 3-hydroxypicolinic acid. Inorganica Chimica Acta 446 (2016) 87–92.

[2]. Zhou L, et al. A mixed matrix of 3-hydroxypicolinic acid and pyrazinecarboxylic acid for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of oligodeoxynucleotides. Rapid Commun Mass Spectrom. 2004;18(7):787-794. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	7.1886 mL	35.9428 mL	71.8856 mL	179.7139 mL
	5 mM	1.4377 mL	7.1886 mL	14.3771 mL	35.9428 mL
	10 mM	0.7189 mL	3.5943 mL	7.1886 mL	17.9714 mL
	15 mM	0.4792 mL	2.3962 mL	4.7924 mL	11.9809 mL
	20 mM	0.3594 mL	1.7971 mL	3.5943 mL	8.9857 mL
	25 mM	0.2875 mL	1.4377 mL	2.8754 mL	7.1886 mL
	30 mM	0.2396 mL	1.1981 mL	2.3962 mL	5.9905 mL
	40 mM	0.1797 mL	0.8986 mL	1.7971 mL	4.4928 mL
	50 mM	0.1438 mL	0.7189 mL	1.4377 mL	3.5943 mL
	60 mM	0.1198 mL	0.5990 mL	1.1981 mL	2.9952 mL
	80 mM	0.0899 mL	0.4493 mL	0.8986 mL	2.2464 mL
	100 mM	0.0719 mL	0.3594 mL	0.7189 mL	1.7971 mL

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3-Hydroxypicolinic acid