2. Neuronal Signaling
  3. Amyloid-β
  4. Solanezumab

Solanezumab  (Synonyms: LY-2062430)

Cat. No.: HY-P99317 Pureza: ≥99.0%
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Solanezumab (LY-2062430) is a humanized monoclonal IgG1 antibody directed against the mid-domain of the amyloid-β (Aβ) peptide. Solanezumab binds to the mid-domain of monomeric amyloid-beta to slow brain amyloid accumulation. Solanezumab can be used for the research of Alzheimer’s disease.

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No. CAS : 955085-14-0

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Solanezumab Related Antibodies

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Descripciòn

Solanezumab (LY-2062430) is a humanized monoclonal IgG1 antibody directed against the mid-domain of the amyloid-β (Aβ) peptide. Solanezumab binds to the mid-domain of monomeric amyloid-beta to slow brain amyloid accumulation. Solanezumab can be used for the research of Alzheimer’s disease[1].
Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

Amyloid Beta/Aβ
In Vivo

Solanezumab can reduces increased amyloid levels in brain but does not slow cognitive decline in Alzheimer’s diseas models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
Gene ID

351  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Peso molecular

144.8 kDa

No. CAS
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Solanezumab]
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized β-Amyloid (12-28) (TFA, HY-P1051A) can bind Solanezumab. The EC50 for this effect is 1.187 ng/mL.
  • Flow cytometric analysis of 1.5×106 HUVEC cells with Solanezumab (HY-P99317, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa, Isotype Control (HY-P99001, blue) was used as the isotype control.
Pureza y Documentación
Referencias
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Solanezumab Related Classifications

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Solanezumab955085-14-0LY-2062430LY2062430LY 2062430Amyloid-ββ-amyloid peptideAβAbetabrain amyloid accumulationpreclinical Alzheimer’s diseasemonomeric amyloid-betaamyloid-beta (Aβ)Inhibitorinhibitorinhibit

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Inquiry Information

Nombre del producto:
Solanezumab
Cat. No.:
HY-P99317
Cantidad:
MCE Japan Authorized Agent:

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