2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. REV-ERB
  4. SR8278

SR8278 is a REV-ERBα antagonist and inhibits the REV-ERBα transcriptional repression activity with an EC50 of 0.47 μM. SR8278 is used to regulate the metabolism in organisms and study biological rhythm. SR8278 also can be used for the research of Duchenne muscular dystrophy and Alzheimer's disease.

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CAS 番号 : 1254944-66-5

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 132 在庫あり
Solution
10 mM * 1 mL in DMSO USD 132 在庫あり
Solid
5 mg $120 在庫あり
10 mg $200 在庫あり
25 mg $400 在庫あり
50 mg $600 在庫あり
100 mg $900 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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カスタマーレビュー

Based on 15 publication(s) in Google Scholar

SR8278 関連抗体

Top Publications Citing Use of Products

    SR8278 purchased from MedChemExpress. Usage Cited in: Int J Oral Sci. 2025 Feb 25;17(1):14.  [Abstract]

    SR8278 (2.5 μM) increased the protein levels of BMAL1, NLRP3, and pro-CASPASE1 and downregulated the full length and N-terminal cleavage of GSDMD in mGFs.

    SR8278 purchased from MedChemExpress. Usage Cited in: Int J Oral Sci. 2025 Feb 25;17(1):14.  [Abstract]

    SR8278 (2.5 μM) ameliorated P. gingivalis LPS-induced death of mGFs.

    SR8278 purchased from MedChemExpress. Usage Cited in: Int J Oral Sci. 2025 Feb 25;17(1):14.  [Abstract]

    SR8278 (500 μM; 110 μL; i.p.; ZT 4) injection reduced GSDMD levels and alleviated alveolar bone resorption and periodontal destruction exacerbated by circadian disruption.

    SR8278 purchased from MedChemExpress. Usage Cited in: In Vitro Cell Dev Biol Anim. 2023 Jan;59(1):76-84.  [Abstract]

    SR8278 promotes the expression of ALPL, BSP, OPN, RUNX2, and OSX signifcantly in OCCM-30 cells.

    SR8278 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2021 Sep 7;12(1):5323.  [Abstract]

    Effects of SR8278 (100 mg/kg; i.g.; once daily for 4 weeks) on BMAL1 and DGAT2 expression in small intestine of HFD-fed mice.

    SR8278 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2021 Sep 7;12(1):5323.  [Abstract]

    SR8278 (100 mg/kg; i.g.; once daily for 4 weeks) significantly increased body weight gain, serum/hepatic/ intestinal TAG and FFA levels in HFD-fed mice.

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    製品説明

    SR8278 is a REV-ERBα antagonist and inhibits the REV-ERBα transcriptional repression activity with an EC50 of 0.47 μM. SR8278 is used to regulate the metabolism in organisms and study biological rhythm. SR8278 also can be used for the research of Duchenne muscular dystrophy and Alzheimer's disease[1][2][3].

    IC50 & Target

    EC50: 0.47 μM (REV-ERBα)[1].
    体外実験

    SR8278 has REV-ERBα transcriptional repression inhibitory activity with an EC50 of 0.47μM[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    SR8278 関連抗体
    体内実験

    SR8278 (slow microinjection; 20 μg/mouse) exerts antidepressant and anxiolytic effects in a circadian time-dependent manner in 6-OHDA-lesioned mice and restores the circadian rhythm of mood-related behaviors[1].
    SR8278 (slow microinjection; 20 μg/mouse) restores the binding activities of REV-ERBα and NURR1 to the tyrosine hydroxylase promoter and the induction of enrichment of the R/N motif, recognized by REV-ERBα and NURR1[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 6-OHDA-lesioned mice[1]
    Dosage: 20 μg/mouse
    Administration: slow microinjection; 20 μg/mouse
    Result: Recovered mood-related behavioral deficits shown in 6-OHDA-lesioned mice.
    Altered remaining DAergic neuron specific transcription levels of REV-ERBα and Nurr1 in the VTA.
    Restored antagonistic crosstalk of REV-ERBα and NURR1 binding activity to TH promoter and TH protein levels in VTA.
    Induced enrichments of REV-ERBα and NURR1 binding motifs at dawn.
    分子量

    361.48

    分子式

    C18H19NO3S2
    CAS 番号
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    CSC1=CC=C(C(N2C(C(OCC)=O)CC(C=CC=C3)=C3C2)=O)S1
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (276.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7664 mL 13.8320 mL 27.6640 mL
    5 mM 0.5533 mL 2.7664 mL 5.5328 mL
    10 mM 0.2766 mL 1.3832 mL 2.7664 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

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    体積 （開始）

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (6.92 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (6.92 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
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    +
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    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.89%

    COA (251 KB) HNMR (175 KB) RP-HPLC (226 KB) MS (230 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.7664 mL 13.8320 mL 27.6640 mL 69.1601 mL
    5 mM 0.5533 mL 2.7664 mL 5.5328 mL 13.8320 mL
    10 mM 0.2766 mL 1.3832 mL 2.7664 mL 6.9160 mL
    15 mM 0.1844 mL 0.9221 mL 1.8443 mL 4.6107 mL
    20 mM 0.1383 mL 0.6916 mL 1.3832 mL 3.4580 mL
    25 mM 0.1107 mL 0.5533 mL 1.1066 mL 2.7664 mL
    30 mM 0.0922 mL 0.4611 mL 0.9221 mL 2.3053 mL
    40 mM 0.0692 mL 0.3458 mL 0.6916 mL 1.7290 mL
    50 mM 0.0553 mL 0.2766 mL 0.5533 mL 1.3832 mL
    60 mM 0.0461 mL 0.2305 mL 0.4611 mL 1.1527 mL
    80 mM 0.0346 mL 0.1729 mL 0.3458 mL 0.8645 mL
    100 mM 0.0277 mL 0.1383 mL 0.2766 mL 0.6916 mL
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    SR8278 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SR82781254944-66-5SR 8278SR-8278REV-ERBREV-ERBαmetabolismbiological rhythmDuchenne muscular dystrophyAlzheimer's diseaseneurosurgeryInhibitorinhibitorinhibit

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    製品名:
    SR8278
    製品番号:
    HY-14415
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