2. Membrane Transporter/Ion Channel
  3. Chloride Channel
  4. Stepronin

Stepronin  (Synonyms: Prostenoglycine; TTPG; Tiase)

製品番号: HY-A0234 純度: 99.54%
COA 取扱説明書 Technical Support

Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Stepronin

Stepronin 構造式

CAS 番号 : 72324-18-6

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 61 在庫あり
Solution
10 mM * 1 mL in DMSO USD 61 在庫あり
Solid
5 mg $56 在庫あり
10 mg $88 在庫あり
25 mg $150 在庫あり
50 mg $225 在庫あり
100 mg $360 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 2 publication(s) in Google Scholar

Other Forms of Stepronin:

Stepronin 関連抗体

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  • 生物活性

  • 純度とドキュメンテーション

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製品説明

Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands[1].

Cellular Effect
Cell Line Type Value Description References
KB 3-1 IC50
0.86 2
Compound: stepronin
Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay
[PMID: 21657271]
KB 3-1 IC50
0.86 2
Compound: stepronin
Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay
[PMID: 21657271]
KB 3-1 IC50
0.86 2
Compound: stepronin
Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay
[PMID: 21657271]
KB-V1 IC50
0.89 2
Compound: stepronin
Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay
Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay
[PMID: 21657271]
KB-V1 IC50
0.89 2
Compound: stepronin
Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay
Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay
[PMID: 21657271]
KB-V1 IC50
0.89 2
Compound: stepronin
Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay
Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay
[PMID: 21657271]
体外実験

Stepronin (0.1-100 μM; 20 min) induces significant reductions in ISOP(Isoproterenol)-evoked SCC (short circuit current) value in a dose-dependent manner in canine tracheal epithelium[1].
Stepronin (10-100 μM; 20 min) significantly inhibits the basal secretion and ISOP-evoked PD (potential difference) value in a dose-dependent manner in canine tracheal epithelium[1].
Stepronin (100 μM; 20 min) significantly inhibits ISOP-induced [3H]-glycoconjugate secretion in submucosal glands[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Stepronin 関連抗体

Cell Viability Assay[1]

Cell Line: Canine tracheal epithelium (from adult and 10 to 25 kg-weight mongrel dogs of both sexes)
Concentration: 0.1-100 µM; 10-100 µM
Incubation Time: 20 min (pre-treat)
Result: Significantly inhibited ISOP-induced SCC and PD values, as well as basal secretion.

Cell Viability Assay[1]

Cell Line: Submucosal glands (from adult and 10 to 25 kg-weight mongrel dogs of both sexes)
Concentration: 100 µM
Incubation Time: 20 min (pre-treat)
Result: Significantly inhibited ISOP- induced [3H]-glycoconjugate secretion.
分子量

273.33

分子式

C10H11NO4S2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CNC(C(SC(C1=CC=CS1)=O)C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 250 mg/mL (914.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6586 mL 18.2929 mL 36.5858 mL
5 mM 0.7317 mL 3.6586 mL 7.3172 mL
10 mM 0.3659 mL 1.8293 mL 3.6586 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
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純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6586 mL 18.2929 mL 36.5858 mL 91.4645 mL
5 mM 0.7317 mL 3.6586 mL 7.3172 mL 18.2929 mL
10 mM 0.3659 mL 1.8293 mL 3.6586 mL 9.1465 mL
15 mM 0.2439 mL 1.2195 mL 2.4391 mL 6.0976 mL
20 mM 0.1829 mL 0.9146 mL 1.8293 mL 4.5732 mL
25 mM 0.1463 mL 0.7317 mL 1.4634 mL 3.6586 mL
30 mM 0.1220 mL 0.6098 mL 1.2195 mL 3.0488 mL
40 mM 0.0915 mL 0.4573 mL 0.9146 mL 2.2866 mL
50 mM 0.0732 mL 0.3659 mL 0.7317 mL 1.8293 mL
60 mM 0.0610 mL 0.3049 mL 0.6098 mL 1.5244 mL
80 mM 0.0457 mL 0.2287 mL 0.4573 mL 1.1433 mL
100 mM 0.0366 mL 0.1829 mL 0.3659 mL 0.9146 mL
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Stepronin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Stepronin72324-18-6Prostenoglycine TTPG TiaseChloride ChannelCl− ChannelsSCCshort circuit currentpotential differencecanine tracheal epitheliumsubmucosal glandsInhibitorinhibitorinhibit

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製品名:
Stepronin
製品番号:
HY-A0234
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