2. Immunology/Inflammation
  3. CD3
  4. Talquetamab

Talquetamab  (Synonyms: JNJ-64407564)

Cat. No.: HY-P99394 Purity: 98.52%
COA
SDS
Technical Support

Talquetamab (JNJ-64407564) is a humanized bispecific antibody that binds to GPRC5D (member of G protein-coupled receptor family C5 group D) and CD3 to induce T cell-mediated killing of GPRC5D-expressing MM cells through T cell recruitment and activation. Talquetamab (JNJ-64407564) has antitumor activity.

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CAS No. : 2226212-40-2

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 견적 받기
100 mg   견적 받기  
200 mg   견적 받기  

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Talquetamab Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Talquetamab

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Talquetamab (JNJ-64407564) is a humanized bispecific antibody that binds to GPRC5D (member of G protein-coupled receptor family C5 group D) and CD3 to induce T cell-mediated killing of GPRC5D-expressing MM cells through T cell recruitment and activation. Talquetamab (JNJ-64407564) has antitumor activity[1][2].

Isotype

Ig(G4-kappa_G4-lambda2)
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

GPRC5D & CD3E
In Vitro

Talquetamab (0.00128-4.0 μg/mL, 48 h) effectively induces multiple myeloma cell lysis and leads to a significant increase in the proportion of activated CD4+ and CD8+ T cells, as well as to a dose-dependent increase in the levels of granzyme B and inflammatory cytokines such as IL-6, IL-8 and TNF-α[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Talquetamab Related Antibodies
In Vivo

Talquetamab (JNJ-64407564) (0.1-50 µg, s.c. or i.v.) has significant antitumor activity in H929 and MM mouse models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NSG mice with H929 cells[2]
Dosage: 0.1-10 µg (0.005 mg/kg)
Administration: Subcutaneous injection; on days 0, 3, 5, 7, and 10
Result: Completely blocked tumor formation at 1 μg and 10 μg doses.
Animal Model: Female NSG mice with human MM cells[2]
Dosage: 0.1-50 µg (0.005 mg/kg)
Administration: Intravenous injection; on days 15, 18, 22, 24, 29, 32, and 36
Result: Significantly inhibited tumor growth by 65% at the dose of 1μg and showed significant anti-tumor activity at 10 and 50 μg with complete tumor regression.
Clinical Trial
Gene ID

55507  [NCBI] & 916  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
분자량

144.58 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Talquetamab]
선적

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human Ig(G4-kappa_G4-lambda2)
Biological Activity
  • Flow cytometry analysis of GPRC5D overexpression CHOK1 cells labelling GPRC5D with Talquetamab at 20 nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/1000 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
  • Flow cytometry analysis of Jurkat cells labelling CD3 with Talquetamab at 20nM (Red). Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/1000 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
순도&문서

Purity: 98.52%

SDS (251 KB)

COA (231 KB) SDS-PAGE (142 KB)

Inhibitory Antibodies User Guide (603 KB)
References
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Talquetamab Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Talquetamab2226212-40-2JNJ-64407564JNJ64407564JNJ 64407564CD3Cluster of differentiation 3GPRC5DantitumorAMLMM cellInhibitorinhibitorinhibit

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상품명:
Talquetamab
Cat. No.:
HY-P99394
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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