2. Anti-infection
  3. Bacterial
  4. TCA1

TCA1 is a small molecule with activity against agent-susceptible and -resistant Mycobacterium tuberculosis (Mtb). TCA1 inhibits enzymes involved in cell wall and molybdenum cofactor biosynthesis, such as DprE1 and MoeW.

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TCA1

TCA1 화학구조

CAS No. : 864941-32-2

사이즈 가격 재고 수량
무료 샘플 (0.1 - 0.2 mg)   지금 신청하기  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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고객리뷰

Based on 1 publication(s) in Google Scholar

TCA1 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE TCA1

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

TCA1 is a small molecule with activity against agent-susceptible and -resistant Mycobacterium tuberculosis (Mtb). TCA1 inhibits enzymes involved in cell wall and molybdenum cofactor biosynthesis, such as DprE1 and MoeW[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
46.1 μg/mL
Compound: TCA1
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 33852302]
Vero IC50
31.77 μg/mL
Compound: TCA1
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 33852302]
In Vitro

TCA1 shows bactericidal activity against both replicating (WT and drug resistant) and nonreplicating Mycobacterium tuberculosis (Mtb). TCA1 inhibits biofilm formation by Mtb H37Rv[1].
TCA1 shows selective inhibitory activity against bacterial growth-it is inactive against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, suggesting that the target for its bactericidal activity is specific to the genus Mycobacterium[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TCA1 Related Antibodies
In Vivo

TCA1 (40 mg/kg; oral gavage; 1 time/d for 5 d/week; for 4 weeks) is efficacious in acute and chronic Mtb infection mouse models[1].
In a mouse model of Mtb infection, after i.v. administration, TCA1 exhibits a low clearance and steady-state volume of distribution, with an elimination half-life of 0.73 h. After oral administration of 20 and 50 mg/kg in solution formulation, TCA1 shows a high Cmax (2122 and 5653 nM, respectively), moderate exposure with oral bioavailability ranging from 19% to 46%, and a half-life of 1.8 h[1]. BALB/c mice infected with Mtb H37Rv[1] 40 mg/kg Oral gavage; 1 time/d for 5 d/week; for 4 weeks Effectively inhibits Mtb in vivo.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
분자량

375.42

화학식

C16H13N3O4S2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=C(C(NC(OCC)=O)=O)C=CS1)C2=NC3=CC=CC=C3S2
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 125 mg/mL (332.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6637 mL 13.3184 mL 26.6368 mL
5 mM 0.5327 mL 2.6637 mL 5.3274 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6637 mL 13.3184 mL 26.6368 mL 66.5921 mL
5 mM 0.5327 mL 2.6637 mL 5.3274 mL 13.3184 mL
10 mM 0.2664 mL 1.3318 mL 2.6637 mL 6.6592 mL
15 mM 0.1776 mL 0.8879 mL 1.7758 mL 4.4395 mL
20 mM 0.1332 mL 0.6659 mL 1.3318 mL 3.3296 mL
25 mM 0.1065 mL 0.5327 mL 1.0655 mL 2.6637 mL
30 mM 0.0888 mL 0.4439 mL 0.8879 mL 2.2197 mL
40 mM 0.0666 mL 0.3330 mL 0.6659 mL 1.6648 mL
50 mM 0.0533 mL 0.2664 mL 0.5327 mL 1.3318 mL
60 mM 0.0444 mL 0.2220 mL 0.4439 mL 1.1099 mL
80 mM 0.0333 mL 0.1665 mL 0.3330 mL 0.8324 mL
100 mM 0.0266 mL 0.1332 mL 0.2664 mL 0.6659 mL
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TCA1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCA1864941-32-2TCA 1TCA-1BacterialDprE1MoeWMycobacteriumtuberculosisoralInhibitorinhibitorinhibit

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상품명:
TCA1
Cat. No.:
HY-12904
수량:
MCE Japan Authorized Agent:

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