Thrombospondin (TSP-1)-derived CD36 binding motif

Cat. No.: HY-P5322 Pureté: 99.58%: Fiche technique
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Thrombospondin (TSP-1)-derived CD36 binding motif is a bioactive hexapeptide. Thrombospondin (TSP-1)-derived CD36 binding motif interferes with the interaction between cells and the extracellular matrix by binding to CD36 and angiostatin, thereby affecting the cell adhesion and migration process. Thrombospondin (TSP-1)-derived CD36 binding motif inhibits platelet aggregation. Thrombospondin (TSP-1)-derived CD36 binding motif exerts an anti-tumor effect against colon cancer.

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Thrombospondin (TSP-1)-derived CD36 binding motif Chemical Structure

CAS No. : 138849-26-0

Size	Stock	Quantité
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
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100 mg	Obtenir un devis

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Activité biologique
Pureté et documentation
Références
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Description

In Vitro

Thrombospondin (TSP-1)-derived CD36 binding motif (200 μM) inhibits thrombospondin surface expression on activated platelets and partially inhibits platelet aggregation in response to agonists such as A23187 (HY-N6687), Epinephrine (HY-B0447B), ADP (HY-W010918), and Collagen^[1].
Thrombospondin (TSP-1)-derived CD36 binding motif (200 μM) completely inhibits the attachment of Retinoic acid (HY-14649)-treated SK-N-SH cells to TSP-1, with an IC₅₀ of 80 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Thrombospondin (TSP-1)-derived CD36 binding motif (10 mg/kg; i.p.; every other day; 4 weeks) shows anti-tumor effects in a murine model of human colon cancer (female BALB/c nu/nu mice)^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c nu/nu mice (weight: 12-18 g, age: 8-10 weeks), human xenograft splenic injection model of colon cancer^[4]
Dosage:	10 mg/kg (in PBS)
Administration:	Intraperitoneal injection, every other day, 4 weeks
Result:	Significantly reduced the primary tumor volume by 69% compared with the control group. Improved the health score and internal disease score, with a minimum 30% improvement in both scores compared with control animals.

Masse moléculaire

566.65

Formule

C₂₀H₃₄N₆O₉S₂

CAS No.

138849-26-0

Appearance

Solid

Color

White to off-white

Sequence

Cys-Ser-Val-Thr-Cys-Gly (Disulfide bridge: Cys1-Cys5)

Sequence Shortening

CSVTCG (Disulfide bridge: Cys1-Cys5)

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité

In Vitro:

H₂O : 10 mg/mL (17.65 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7648 mL	8.8238 mL	17.6476 mL
5 mM	0.3530 mL	1.7648 mL	3.5295 mL
10 mM	0.1765 mL	0.8824 mL	1.7648 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureté et documentation

Purity: 99.58%

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Fiche technique (284 KB) SDS (252 KB)

COA (261 KB) RP-HPLC (111 KB) MS (219 KB) Elemental Analysis Report (121 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Asch AS, et al. Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding. Biochem Biophys Res Commun. 1992 Feb 14;182(3):1208-17. [Content Brief]

[2]. Pijuan-Thompson V, et al. Retinoic acid alters the mechanism of attachment of malignant astrocytoma and neuroblastoma cells to thrombospondin-1. Exp Cell Res. 1999 May 25;249(1):86-101. [Content Brief]

[3]. Tsao PW, et al. Thrombospondin mediates calcium mobilization in fibroblasts via its Arg-Gly-Asp and carboxyl-terminal domains. J Biol Chem. 1995 Oct 6;270(40):23747-53. [Content Brief]

[4]. Liebig C, et al. Angiocidin inhibitory peptides decrease tumor burden in a murine colon cancer model. J Surg Res. 2007 Oct;142(2):320-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.7648 mL	8.8238 mL	17.6476 mL	44.1189 mL
	5 mM	0.3530 mL	1.7648 mL	3.5295 mL	8.8238 mL
	10 mM	0.1765 mL	0.8824 mL	1.7648 mL	4.4119 mL
	15 mM	0.1177 mL	0.5883 mL	1.1765 mL	2.9413 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.