Thymine-¹³C₅,¹⁵N,¹⁵N₂  (Synonyms: 5-Methyluacil-¹³C₅,¹⁵N,¹⁵N₂)

Thymine-¹³C₅,¹⁵N₂ (5-Methyluacil-¹³C₅,¹⁵N₂) is ¹³C and ¹⁵N labeled Thymine. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a K_m of 2.3 μM^[1].

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

133.06

¹³C₅H₆¹⁵N₂O₂

2483830-13-1

65-71-4

O=[13C]1[13C]([13CH3])=[13CH][15NH][13C]([15NH]1)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Tuchman M, et al. Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase. Cancer Res. 1985 Nov;45(11 Pt 1):5553-6.  [Content Brief]