2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. Tovecimig

Tovecimig  (Synonyms: CTX-009)

Art. -Nr.: HY-P991033 Reinheit: 97.39%
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HY-P991033 is an VEGFA/DLL4-targeting G1-scFvlh_L-κ type bispecific antibody.

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CAS. Nr. : 2923284-73-3

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Tovecimig Related Antibodies

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Alle VEGFR Isoform-spezifische Produkte anzeigen:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Beschreibung

HY-P991033 is an VEGFA/DLL4-targeting G1-scFvlh_L-κ type bispecific antibody[1].

Isotype

IgG1-kappa-[scFv]2-lambda-heavy
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

VEGFA & DLL4
Klinische Studie
Gene ID

7422  [NCBI] & 54567  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molekulargewicht

199.624 kDa

CAS. Nr.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Tovecimig]
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • IgG1-kappa-[scFv]2-lambda-heavy
Biological Activity
  • Immobilized VEGF121 Protein, Human (120 a.a, HY-P7420) can bind Tovecimig. The EC50 for this effect is 10.9 ng/mL.
  • Immobilized Delta-like protein 4/DLL4 Protein, Human (HEK293, HY-P72972) can bind Tovecimig. The EC50 for this effect is 16.06 ng/mL.
  • Flow cytometric analysis of 1X106 HeLa cells with Tovecimig (HY-P991033, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control.
Reinheit & Dokumentation
Verweise
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Tovecimig Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tovecimig2923284-73-3CTX-009CTX009CTX 009VEGFRVascular endothelial growth factor receptorInhibitorinhibitorinhibit

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