2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. trans-Platinum(II)diammine dichloride

trans-Platinum(II)diammine dichloride  (Synonyms: trans-platinumdiamminedichloride)

製品番号: HY-W075885 純度: 99.90%
COA 取扱説明書 Technical Support

trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394). Trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum(II)diammine dichloride is useful for studying DNA-protein cross-links.

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trans-Platinum(II)diammine dichloride

trans-Platinum(II)diammine dichloride 構造式

CAS 番号 : 14913-33-8

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in DMSO USD 33 在庫あり
Solid
100 mg $30 在庫あり
250 mg $55 在庫あり
500 mg $85 在庫あり
1 g $136 在庫あり
5 g $355 在庫あり
10 g   お問い合わせ  
50 g   お問い合わせ  

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trans-Platinum(II)diammine dichloride 関連抗体

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製品説明

trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394). Trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum(II)diammine dichloride is useful for studying DNA-protein cross-links[1][2].

体外実験

trans-Platinum(II)diammine dichloride (20-200 μM, 0-24 h) induces DNA cross-linking but does not cause DNA fragmentation, and its cytotoxicity to L1210 cells is approximately one order of magnitude lower than that of Cisplatin[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

trans-Platinum(II)diammine dichloride 関連抗体
分子量

300.05

分子式

Cl2H6N2Pt
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

Cl[Pt]Cl.N.N
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Store at room temperature, keep dry and cool

*In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature, keep dry and cool)
溶剤 & 溶解度
体外: 

DMF : 10 mg/mL (33.33 mM; ultrasonic and warming and heat to 60°C; DMSO can inactivate trans-Platinum(II)diammine dichloride's activity)

H2O : 2 mg/mL (6.67 mM; ultrasonic and warming and heat to 60°C; DMSO can inactivate trans-Platinum(II)diammine dichloride's activity)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3328 mL 16.6639 mL 33.3278 mL
5 mM 0.6666 mL 3.3328 mL 6.6656 mL
10 mM 0.3333 mL 1.6664 mL 3.3328 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.90%

COA (247 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMF 1 mM 3.3328 mL 16.6639 mL 33.3278 mL 83.3195 mL
5 mM 0.6666 mL 3.3328 mL 6.6656 mL 16.6639 mL
DMF 10 mM 0.3333 mL 1.6664 mL 3.3328 mL 8.3319 mL
15 mM 0.2222 mL 1.1109 mL 2.2219 mL 5.5546 mL
20 mM 0.1666 mL 0.8332 mL 1.6664 mL 4.1660 mL
25 mM 0.1333 mL 0.6666 mL 1.3331 mL 3.3328 mL
30 mM 0.1111 mL 0.5555 mL 1.1109 mL 2.7773 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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trans-Platinum(II)diammine dichloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

trans-Platinum(II)diammine dichloride14913-33-8trans-platinumdiamminedichlorideDNA Alkylator/CrosslinkerDNA-Protein CrosslinkAlkaline ElutionQuantitative ModelCytotoxicityInhibitorinhibitorinhibit

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