14913-33-8
14913-33-8
Chemical Structure
trans-Platinum(II)diammine dichloride
Synonym(s): trans-platinumdiamminedichloride
- CAS No.: 14913-33-8
- Formula:Cl2H6N2Pt
- Molecular Weight:300.05
InChIKey: LXZZYRPGZAFOLE-UHFFFAOYSA-L
SMILES: Cl[Pt]Cl.N.N
Biological Activity: trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394). Trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum(II)diammine dichloride is useful for studying DNA-protein cross-links[1][2].
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trans-Platinum(II)diammine dichloride | 99.9% | trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394). Trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum(II)diammine dichloride is useful for studying DNA-protein cross-links. | ||||||||||||||||||||
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trans-Platinum(II)diammine dichloride (Standard) | ≥98% | trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) (Standard) is an analytical standard for trans-Platinum(II)diammine dichloride (HY-W075885). This product is intended for research and analytical applications. trans-Platinum(II)diammine dichloride is a geometric isomer of Cisplatin (HY-17394). trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage but exhibits low cytotoxicity. trans-Platinum(II)diammine dichloride can be used to study DNA-protein cross-links. | ||||||||||||||||||||
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References
- [1]. Zwelling LA, Anderson T, Kohn KW. DNA-protein and DNA interstrand cross-linking by cis- and trans-platinum(II) diamminedichloride in L1210 mouse leukemia cells and relation to cytotoxicity. Cancer Res. 1979 Feb;39(2 Pt 1):365-9. [Content Brief]
- [2]. Kohn KW, Ewig RA. DNA-protein crosslinking by trans-platinum(II)diamminedichloride in mammalian cells, a new method of analysis. Biochim Biophys Acta. 1979 Mar 28;562(1):32-40. [Content Brief]
