2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. trans-Platinum(II)diammine dichloride

trans-Platinum(II)diammine dichloride  (Synonyms: trans-platinumdiamminedichloride)

Cat. No.: HY-W075885 Purity: 99.90%
COA
SDS
Handling Instructions Technical Support

trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394). Trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum(II)diammine dichloride is useful for studying DNA-protein cross-links.

For research use only. We do not sell to patients.

trans-Platinum(II)diammine dichloride

trans-Platinum(II)diammine dichloride Chemical Structure

CAS No. : 14913-33-8

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Based on 1 publication(s) in Google Scholar

Other Forms of trans-Platinum(II)diammine dichloride:

trans-Platinum(II)diammine dichloride Related Antibodies

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  • Purity & Documentation

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Description

trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394). Trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum(II)diammine dichloride is useful for studying DNA-protein cross-links[1][2].

In Vitro

trans-Platinum(II)diammine dichloride (20-200 μM, 0-24 h) induces DNA cross-linking but does not cause DNA fragmentation, and its cytotoxicity to L1210 cells is approximately one order of magnitude lower than that of Cisplatin[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

trans-Platinum(II)diammine dichloride Related Antibodies
Molecular Weight

300.05

Formula

Cl2H6N2Pt
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

Cl[Pt]Cl.N.N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature, keep dry and cool

In solvent -80°C 1 year
-20°C 6 months
Solvent & Solubility
In Vitro: 

DMF : 10 mg/mL (33.33 mM; ultrasonic and warming and heat to 60°C; DMSO can inactivate trans-Platinum(II)diammine dichloride's activity)

H2O : 2 mg/mL (6.67 mM; ultrasonic and warming and heat to 60°C; DMSO can inactivate trans-Platinum(II)diammine dichloride's activity)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3328 mL 16.6639 mL 33.3278 mL
5 mM 0.6666 mL 3.3328 mL 6.6656 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.90%

SDS (640 KB)

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMF 1 mM 3.3328 mL 16.6639 mL 33.3278 mL 83.3195 mL
5 mM 0.6666 mL 3.3328 mL 6.6656 mL 16.6639 mL
DMF 10 mM 0.3333 mL 1.6664 mL 3.3328 mL 8.3319 mL
15 mM 0.2222 mL 1.1109 mL 2.2219 mL 5.5546 mL
20 mM 0.1666 mL 0.8332 mL 1.6664 mL 4.1660 mL
25 mM 0.1333 mL 0.6666 mL 1.3331 mL 3.3328 mL
30 mM 0.1111 mL 0.5555 mL 1.1109 mL 2.7773 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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trans-Platinum(II)diammine dichloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

trans-Platinum(II)diammine dichloride14913-33-8trans-platinumdiamminedichlorideDNA Alkylator/CrosslinkerDNA-Protein CrosslinkAlkaline ElutionQuantitative ModelCytotoxicityInhibitorinhibitorinhibit

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