trans-Platinum(II)diammine dichloride
Based on 1 Customer Validation
trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394). Trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum(II)diammine dichloride is useful for studying DNA-protein cross-links.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 14913-33-8
- Formula: Cl2H6N2Pt
- Molecular Weight:300.05
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-W008145
Sodium tetrachloropalladate(II)
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HY-W075885R
trans-Platinum(II)diammine dichloride (Standard)
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HY-107754
Cesium chloride
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HY-W019894
Manganese chloride
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HY-108775A
Sodium thiosulfate (99%, water≤1.0%)
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HY-W105970
Sodium pyrophosphate
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HY-Y0998
Potassium hexacyanoferrate(III), 99.5%
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HY-Y1885
Tetrasodium pyrophosphate
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HY-Y0416
Potassium ferrocyanide trihydrate, 98.5%
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HY-Y1673
Potassium bromide, 99%
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HY-112030
Dipotassium tetrachloroplatinate
Biological Activity
trans-Platinum(II)diammine dichloride (20-200 μM, 0-24 h) induces DNA cross-linking but does not cause DNA fragmentation, and its cytotoxicity to L1210 cells is approximately one order of magnitude lower than that of Cisplatin[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 14913-33-8
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Appearance Solid
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Molecular Weight 300.05
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Formula Cl2H6N2Pt
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Color Light yellow to yellow
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SMILES
Cl[Pt]Cl.N.N
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Synonyms
trans-platinumdiamminedichloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
DMF : 10 mg/mL (33.33 mM; ultrasonic and warming and heat to 60°C; DMSO can inactivate trans-Platinum(II)diammine dichloride's activity)
H2O : 2 mg/mL (6.67 mM; ultrasonic and warming and heat to 60°C; DMSO can inactivate trans-Platinum(II)diammine dichloride's activity)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (640 KB)
- English - EN (640 KB)
- Français - FR (640 KB)
- Deutsch - DE (640 KB)
- Norwegian - NO (640 KB)
- Español - ES (640 KB)
- Swedish - SV (640 KB)
- Italian - IT (640 KB)
- Korean - KR (640 KB)
- Portuguese - PT (640 KB)
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Handling Instructions (2659 KB)
References
[1]. Zwelling LA, Anderson T, Kohn KW. DNA-protein and DNA interstrand cross-linking by cis- and trans-platinum(II) diamminedichloride in L1210 mouse leukemia cells and relation to cytotoxicity. Cancer Res. 1979 Feb;39(2 Pt 1):365-9. [Content Brief]
[2]. Kohn KW, Ewig RA. DNA-protein crosslinking by trans-platinum(II)diamminedichloride in mammalian cells, a new method of analysis. Biochim Biophys Acta. 1979 Mar 28;562(1):32-40. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMF | 1 mM | 3.3328 mL | 16.6639 mL | 33.3278 mL | 83.3195 mL |
| 5 mM | 0.6666 mL | 3.3328 mL | 6.6656 mL | 16.6639 mL | |
| DMF | 10 mM | 0.3333 mL | 1.6664 mL | 3.3328 mL | 8.3319 mL |
| 15 mM | 0.2222 mL | 1.1109 mL | 2.2219 mL | 5.5546 mL | |
| 20 mM | 0.1666 mL | 0.8332 mL | 1.6664 mL | 4.1660 mL | |
| 25 mM | 0.1333 mL | 0.6666 mL | 1.3331 mL | 3.3328 mL | |
| 30 mM | 0.1111 mL | 0.5555 mL | 1.1109 mL | 2.7773 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
trans-Platinum(II)diammine dichloride Related Classifications
HY-W075885 Related Classifications
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