Manganese chloride
Based on 1 publication(s) in Google Scholar
Manganese chloride is an orally active MRI liver contrast agent. Manganese chloride induces Apoptosis and activates the mTOR signaling pathway. Manganese chloride induces cognitive impairment, promotes hematopoietic recovery, and reduces radiation-induced bone marrow and brain damage. It can be used for the study of renal impairment.
For research use only. We do not sell to patients.
- Purity: 99.1%
- CAS No.: 7773-01-5
- Formula: Cl2Mn
- Molecular Weight:125.84
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Manganese chloride
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Biological Activity
Manganese chloride (200-800 μM; 24 h) reduces the viability of N27 cells, induces abnormal cell morphology and apoptosis, and activates the mTOR signaling pathway[2].
Manganese chloride (200 μM; 24 h) reduces the viability of SH-SY5Y cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:N27 cells
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Concentration:200 μM, 400 μM, 800 μM
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Incubation Time:24 h
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Result:Significantly increased the expression of cleaved-caspase 3.
Activated the mTOR signaling pathway, as evidenced by increased phosphorylation levels of mTOR, 4E-BP1, S6K1, Akt, and SGK1 (detected by Western blotting).
Manganese chloride (4.5-13.5 mg/kg; s.c.; 3 days (for 4.5 mg/kg)) improves the survival rate, promotes hematopoietic recovery, and reduces radiation-induced bone marrow and brain damage in male and female B6D2F1J mice (10-11 weeks old) exposed to 9.5 Gy whole-body Co60 γ-radiation[4].
Manganese chloride (59.36 mg/kg; p.o.; five times a week; 6 weeks) induces neurotoxicity in male albino rats, characterized by upregulated HAT1, HDAC1, PI3K gene expression, global DNA hypermethylation, and cerebellar histological damage[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male SPF SD rats (6 weeks old, 200 g)[2]
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Dosage:5 mg/kg, 15 mg/kg, 30 mg/kg
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Administration:intraperitoneal injection, five times a week, 90 days
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Result:Prolonged the escape latency in the Morris water maze test.
Decreased the number of platform crossings and the time spent in the target quadrant (indicating cognitive impairment), increased the number of TUNEL-positive cells in the substantia nigra.
Upregulated cleaved-caspase 3 expression and the phosphorylation of mTOR, 4E-BP1, S6K1, Akt, SGK1 in the brain.
Chemical Information
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CAS No. 7773-01-5
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Appearance Solid
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Molecular Weight 125.84
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Formula Cl2Mn
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Color Off-white to pink
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SMILES
Cl[Mn]Cl
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Synonyms
Manganese dichloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Colloid Interface Sci
Manganese-based metal-organic frameworks augment postoperative immunotherapy of high-intensity focused ultrasound. [Abstract]2026 Apr 15:708:139847. PMID: 41518922
Solvent & Solubility
1 M HCl : 150 mg/mL (1191.99 mM; Need ultrasonic)
H2O : 100 mg/mL (794.66 mM; ultrasonic and adjust pH to 2 with 1 M HCl)
DMSO : 50 mg/mL (397.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (949 KB)
- English - EN (949 KB)
- Français - FR (949 KB)
- Deutsch - DE (949 KB)
- Norwegian - NO (949 KB)
- Español - ES (949 KB)
- Swedish - SV (949 KB)
- Italian - IT (949 KB)
- Korean - KR (949 KB)
- Portuguese - PT (949 KB)
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Handling Instructions (2659 KB)
References
[1]. Brismar TB, et al. Oral Manganese Chloride Tetrahydrate: A Novel Magnetic Resonance Liver Imaging Agent for Patients With Renal Impairment: Efficacy, Safety, and Clinical Implication. Invest Radiol. 2024 Feb 1;59(2):197-205. [Content Brief]
[2]. Cen Y, et al. Manganese induces neuronal apoptosis by activating mTOR signaling pathway in vitro and in vivo. Food Chem Toxicol. 2024 Mar;185:114508. [Content Brief]
[4]. Hood MN, et al. Preliminary Promising Findings for Manganese Chloride as a Novel Radiation Countermeasure Against Acute Radiation Syndrome. Mil Med. 2024 Aug 19;189(Suppl 3):598-607. [Content Brief]
[5]. Salami AT, et al. Attenuation of Experimental Cholesterol Gallstone Formation by Manganese Chloride in Mice: Role of NF-κβ Pathways. Biol Trace Elem Res. 2025 Aug;203(8):4164-4182. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O / 1 M HCl | 1 mM | 7.9466 mL | 39.7330 mL | 79.4660 mL | 198.6650 mL |
| 5 mM | 1.5893 mL | 7.9466 mL | 15.8932 mL | 39.7330 mL | |
| 10 mM | 0.7947 mL | 3.9733 mL | 7.9466 mL | 19.8665 mL | |
| 15 mM | 0.5298 mL | 2.6489 mL | 5.2977 mL | 13.2443 mL | |
| 20 mM | 0.3973 mL | 1.9866 mL | 3.9733 mL | 9.9332 mL | |
| 25 mM | 0.3179 mL | 1.5893 mL | 3.1786 mL | 7.9466 mL | |
| 30 mM | 0.2649 mL | 1.3244 mL | 2.6489 mL | 6.6222 mL | |
| 40 mM | 0.1987 mL | 0.9933 mL | 1.9866 mL | 4.9666 mL | |
| 50 mM | 0.1589 mL | 0.7947 mL | 1.5893 mL | 3.9733 mL | |
| 60 mM | 0.1324 mL | 0.6622 mL | 1.3244 mL | 3.3111 mL | |
| 80 mM | 0.0993 mL | 0.4967 mL | 0.9933 mL | 2.4833 mL | |
| 100 mM | 0.0795 mL | 0.3973 mL | 0.7947 mL | 1.9866 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Manganese chloride Related Classifications
HY-W019894 Related Classifications
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