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  4. Manganese chloride

Manganese chloride  (Synonyms: Manganese dichloride)

Cat. No.: HY-W019894 Purity: 99.1%
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Manganese chloride is an orally active MRI liver contrast agent. Manganese chloride induces Apoptosis and activates the mTOR signaling pathway. Manganese chloride induces cognitive impairment, promotes hematopoietic recovery, and reduces radiation-induced bone marrow and brain damage. It can be used for the study of renal impairment.

For research use only. We do not sell to patients.

Manganese chloride

Manganese chloride Chemical Structure

CAS No. : 7773-01-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

Manganese chloride Related Antibodies

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1 Publications Citing Use of MCE Manganese chloride

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Description

Manganese chloride is an orally active MRI liver contrast agent. Manganese chloride induces Apoptosis and activates the mTOR signaling pathway. Manganese chloride induces cognitive impairment, promotes hematopoietic recovery, and reduces radiation-induced bone marrow and brain damage. It can be used for the study of renal impairment[1][2][3][4][5][6].

In Vitro

Manganese chloride (200-800 μM; 24 h) reduces the viability of N27 cells, induces abnormal cell morphology and apoptosis, and activates the mTOR signaling pathway[2].
Manganese chloride (200 μM; 24 h) reduces the viability of SH-SY5Y cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Manganese chloride Related Antibodies

Western Blot Analysis[2]

Cell Line: N27 cells
Concentration: 200 μM, 400 μM, 800 μM
Incubation Time: 24 h
Result: Significantly increased the expression of cleaved-caspase 3.
Activated the mTOR signaling pathway, as evidenced by increased phosphorylation levels of mTOR, 4E-BP1, S6K1, Akt, and SGK1 (detected by Western blotting).
In Vivo

Manganese chloride (5-30 mg/kg; i.p.; five times a week; 90 days) induces cognitive impairment, neuronal apoptosis in the substantia nigra, and activation of mTOR signaling pathway in SD rats[2].
Manganese chloride (4.5-13.5 mg/kg; s.c.; 3 days (for 4.5 mg/kg)) improves the survival rate, promotes hematopoietic recovery, and reduces radiation-induced bone marrow and brain damage in male and female B6D2F1J mice (10-11 weeks old) exposed to 9.5 Gy whole-body Co60 γ-radiation[4].
Manganese chloride (59.36 mg/kg; p.o.; five times a week; 6 weeks) induces neurotoxicity in male albino rats, characterized by upregulated HAT1, HDAC1, PI3K gene expression, global DNA hypermethylation, and cerebellar histological damage[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SPF SD rats (6 weeks old, 200 g)[2]
Dosage: 5 mg/kg, 15 mg/kg, 30 mg/kg
Administration: intraperitoneal injection, five times a week, 90 days
Result: Prolonged the escape latency in the Morris water maze test.
Decreased the number of platform crossings and the time spent in the target quadrant (indicating cognitive impairment), increased the number of TUNEL-positive cells in the substantia nigra.
Upregulated cleaved-caspase 3 expression and the phosphorylation of mTOR, 4E-BP1, S6K1, Akt, SGK1 in the brain.
Molecular Weight

125.84

Formula

Cl2Mn
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

Cl[Mn]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

1 M HCl : 150 mg/mL (1191.99 mM; Need ultrasonic)

H2O : 100 mg/mL (794.66 mM; ultrasonic and adjust pH to 2 with 1 M HCl)

DMSO : 50 mg/mL (397.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.9466 mL 39.7330 mL 79.4660 mL
5 mM 1.5893 mL 7.9466 mL 15.8932 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.1%

SDS (949 KB)

COA (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O / 1 M HCl 1 mM 7.9466 mL 39.7330 mL 79.4660 mL 198.6650 mL
5 mM 1.5893 mL 7.9466 mL 15.8932 mL 39.7330 mL
10 mM 0.7947 mL 3.9733 mL 7.9466 mL 19.8665 mL
15 mM 0.5298 mL 2.6489 mL 5.2977 mL 13.2443 mL
20 mM 0.3973 mL 1.9866 mL 3.9733 mL 9.9332 mL
25 mM 0.3179 mL 1.5893 mL 3.1786 mL 7.9466 mL
30 mM 0.2649 mL 1.3244 mL 2.6489 mL 6.6222 mL
40 mM 0.1987 mL 0.9933 mL 1.9866 mL 4.9666 mL
50 mM 0.1589 mL 0.7947 mL 1.5893 mL 3.9733 mL
60 mM 0.1324 mL 0.6622 mL 1.3244 mL 3.3111 mL
80 mM 0.0993 mL 0.4967 mL 0.9933 mL 2.4833 mL
100 mM 0.0795 mL 0.3973 mL 0.7947 mL 1.9866 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Manganese chloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Manganese7773-01-5Manganese dichlorideBiochemical Assay ReagentsApoptosismTORMammalian target of RapamycinMRIcontrast agentsMBCAsInhibitorinhibitorinhibit

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