7773-01-5
7773-01-5
Chemical Structure
Manganese chloride
Synonym(s): Manganese dichloride
- CAS No.: 7773-01-5
- Formula:Cl2Mn
- Molecular Weight:125.84
IUPAC Name: manganese(II) chloride
InChIKey: GLFNIEUTAYBVOC-UHFFFAOYSA-L
SMILES: Cl[Mn]Cl
Biological Activity: Manganese chloride is an orally active MRI liver contrast agent. Manganese chloride induces Apoptosis and activates the mTOR signaling pathway. Manganese chloride induces cognitive impairment, promotes hematopoietic recovery, and reduces radiation-induced bone marrow and brain damage. It can be used for the study of renal impairment[1][2][3][4][5][6].
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Manganese chloride | 99.1% | Manganese chloride is an orally active MRI liver contrast agent. Manganese chloride induces Apoptosis and activates the mTOR signaling pathway. Manganese chloride induces cognitive impairment, promotes hematopoietic recovery, and reduces radiation-induced bone marrow and brain damage. It can be used for the study of renal impairment. | ||||||||||||||||||||
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References
- [1]. Brismar TB, et al. Oral Manganese Chloride Tetrahydrate: A Novel Magnetic Resonance Liver Imaging Agent for Patients With Renal Impairment: Efficacy, Safety, and Clinical Implication. Invest Radiol. 2024 Feb 1;59(2):197-205. [Content Brief]
- [2]. Cen Y, et al. Manganese induces neuronal apoptosis by activating mTOR signaling pathway in vitro and in vivo. Food Chem Toxicol. 2024 Mar;185:114508. [Content Brief]
- [3]. Liang J, et al. Effects and mechanisms of water extract of Uraria crinit a on manganese chloride-induced apoptosis in SH-SY5Y cells. CyTA-Journal of Food, 2025, 23(1): 2463499.
- [4]. Hood MN, et al. Preliminary Promising Findings for Manganese Chloride as a Novel Radiation Countermeasure Against Acute Radiation Syndrome. Mil Med. 2024 Aug 19;189(Suppl 3):598-607. [Content Brief]
- [5]. Salami AT, et al. Attenuation of Experimental Cholesterol Gallstone Formation by Manganese Chloride in Mice: Role of NF-κβ Pathways. Biol Trace Elem Res. 2025 Aug;203(8):4164-4182. [Content Brief]
- [6]. Hussein A S A, et al. Quercetin or Rosmary extract mitigates Manganese chloride-induced Neurotoxicity through Regulation of DNA Methylation and Histone Acetylation and alleviation of apoptosis in rats. Journal of Advanced Veterinary Research, 2024, 14(6): 930-935.
Keywords
