Tetrasodium pyrophosphate

Name: Tetrasodium pyrophosphate
Brand: MedChemExpress
SKU: HY-Y1885
Rating: 4.5 (1 reviews)

Cat. No.: HY-Y1885 Purity: 99.60%: Data Sheet
COA

SDS
Handling Instructions
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Tetrasodium pyrophosphate is a chelating that can bind calcium and help improve olfaction. Tetrasodium pyrophosphate is an antimicrobial agent that can reduce microbial colonization. Tetrasodium pyrophosphate blocks IPP translocation, enhances astaxanthin, phenol, flavonoid, and H₂O₂ levels, activates PAL and DPPH scavenging activity. Tetrasodium pyrophosphate can be used for the research of alleviating symptoms post COVID-19.

For research use only. We do not sell to patients.

Tetrasodium pyrophosphate Chemical Structure

CAS No. : 7722-88-5

Size	Stock	Quantity
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Tetrasodium pyrophosphate (1 mM; 2 h) alleviates the oxidative suppression of transglutaminase-mediated crosslinking in pork Longissimus lumborum actomyosin, as indicated by a reduced decline in transglutaminase-induced free amine reduction^[1].
Tetrasodium pyrophosphate (1 mM; 2 h) modulates transglutaminase crosslinking patterns in pork Longissimus lumborum actomyosin, promoting crosslinking at the S1 and HMM domains, impeding Rod domain crosslinking, and slowing the oxidative stress-induced shift of primary crosslinking sites from S1 to S2^[1].
Tetrasodium pyrophosphate (0.1-0.4 mM; 14-21 days) stimulates astaxanthin production in Haematococcus pluvialis cells, while also increasing total phenol content, DPPH scavenging activity, PAL activity, and H₂O₂ content, with no significant effect on SOD or CAT activity and a reduction in protein content^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tetrasodium pyrophosphate (2000 mg/kg; i.g. or topical; single dose) shows no acute toxicity in Sprague Dawley rats^[4].
Tetrasodium pyrophosphate (250-1000 mg/kg; i.g..; five times weekly; 90 days) shows no toxicity in Sprague Dawley rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague Dawley rats (6-week-old female,160-220 g)^[4]
Dosage:	2000 mg/kg
Administration:	i.g. or topical; single dose
Result:	Showed no dead animals, clinical signs of toxicity, or abnormal necropsy findings in rats administered via oral or dermal routes. Determined LD₅₀ for oral and dermal exposure is greater than 2000 mg/kg.

Animal Model:	Sprague Dawley rats (6-week-old female,160-220 g)^[4]
Dosage:	250; 500; 1000 mg/kg
Administration:	i.g.; five times weekly; 90 days
Result:	Showed no treatment-related mortality across all doses. Observed hair loss in female rats treated with 500 mg/kg and 1000 mg/kg. Found no urinalysis abnormalities at any dose. Observed no significant hematology changes in the 250 mg/kg group. Showed no serum biochemistry changes at 250 mg/kg. Found no significant organ weight changes at 250 mg/kg. Observed no exposure-related histopathology changes in organs other than the kidney.

Molecular Weight

265.90

Formula

Na₄P₂O₇

CAS No.

7722-88-5

Appearance

Solid

Color

White to off-white

SMILES

[Na].O=P(O)(O)OP(=O)(O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (188.04 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7608 mL	18.8041 mL	37.6081 mL
5 mM	0.7522 mL	3.7608 mL	7.5216 mL
10 mM	0.3761 mL	1.8804 mL	3.7608 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.60%

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Data Sheet (275 KB) SDS (477 KB)

COA (247 KB)

Handling Instructions (2659 KB)

References

[1]. Wang Q, et al. Tetrasodium pyrophosphate ameliorates oxidative damage to the TGase-catalyzed gelation of actomyosins. Food Chem. 2022;378:132128. [Content Brief]

[2]. Pedrazzi V, et al. Clinical evaluation of residual tetrasodium pyrophosphate released from two different anticalculus flosses. Braz Dent J. 2015;26(2):116-120. [Content Brief]

[3]. Hassanpour H, et al. Impact of sodium pyrophosphate and static magnetic field on Haematococcus pluvialis: enhancement of astaxanthin accumulation, PAL, and antioxidant enzyme activities. Physiol Mol Biol Plants. 2022 Jun;28(6):1207-1216. [Content Brief]

[4]. Seo DS, et al. Acute Oral or Dermal and Repeated Dose 90-Day Oral Toxicity of Tetrasodium Pyrophosphate in Spraque Dawley (SD) Rats. Environ Health Toxicol. 2011;26:e2011014. [Content Brief]

[5]. Abdelazim, M. H., et al., (2022). The effect of intra-nasal tetra sodium pyrophosphate on decreasing elevated nasal calcium and improving olfactory function post COVID-19: a randomized controlled trial. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 18(1), 67. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.7608 mL	18.8041 mL	37.6081 mL	94.0203 mL
	5 mM	0.7522 mL	3.7608 mL	7.5216 mL	18.8041 mL
	10 mM	0.3761 mL	1.8804 mL	3.7608 mL	9.4020 mL
	15 mM	0.2507 mL	1.2536 mL	2.5072 mL	6.2680 mL
	20 mM	0.1880 mL	0.9402 mL	1.8804 mL	4.7010 mL
	25 mM	0.1504 mL	0.7522 mL	1.5043 mL	3.7608 mL
	30 mM	0.1254 mL	0.6268 mL	1.2536 mL	3.1340 mL
	40 mM	0.0940 mL	0.4701 mL	0.9402 mL	2.3505 mL
	50 mM	0.0752 mL	0.3761 mL	0.7522 mL	1.8804 mL
	60 mM	0.0627 mL	0.3134 mL	0.6268 mL	1.5670 mL
	80 mM	0.0470 mL	0.2351 mL	0.4701 mL	1.1753 mL
	100 mM	0.0376 mL	0.1880 mL	0.3761 mL	0.9402 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.