Tetrasodium pyrophosphate
Based on 1 Customer Validation
Tetrasodium pyrophosphate is a water-soluble inorganic salt commonly used as a buffering agent, emulsifier, and sequestrant. Tetrasodium pyrophosphate is an antimicrobial agent that can reduce microbial colonization. Tetrasodium pyrophosphate blocks IPP translocation, enhances astaxanthin, phenol, flavonoid, and H2O2 levels, activates PAL and DPPH scavenging activity. Tetrasodium pyrophosphate can be used for the research of alleviating symptoms post COVID-19.
For research use only. We do not sell to patients.
- Purity: 99.60%
- CAS No.: 7722-88-5
- Formula: Na4P2O7
- Molecular Weight:265.90
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Tetrasodium pyrophosphate (1 mM; 2 h) alleviates the oxidative suppression of transglutaminase-mediated crosslinking in pork Longissimus lumborum actomyosin, as indicated by a reduced decline in transglutaminase-induced free amine reduction[1].
Tetrasodium pyrophosphate (1 mM; 2 h) modulates transglutaminase crosslinking patterns in pork Longissimus lumborum actomyosin, promoting crosslinking at the S1 and HMM domains, impeding Rod domain crosslinking, and slowing the oxidative stress-induced shift of primary crosslinking sites from S1 to S2[1].
Tetrasodium pyrophosphate (0.1-0.4 mM; 14-21 days) stimulates astaxanthin production in Haematococcus pluvialis cells, while also increasing total phenol content, DPPH scavenging activity, PAL activity, and H2O2 content, with no significant effect on SOD or CAT activity and a reduction in protein content[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Tetrasodium pyrophosphate (250-1000 mg/kg; i.g..; five times weekly; 90 days) shows no toxicity in Sprague Dawley rats[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague Dawley rats (6-week-old female,160-220 g)[4]
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Dosage:2000 mg/kg
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Administration:i.g. or topical; single dose
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Result:Showed no dead animals, clinical signs of toxicity, or abnormal necropsy findings in rats administered via oral or dermal routes.
Determined LD50 for oral and dermal exposure is greater than 2000 mg/kg.
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Animal Model:Sprague Dawley rats (6-week-old female,160-220 g)[4]
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Dosage:250; 500; 1000 mg/kg
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Administration:i.g.; five times weekly; 90 days
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Result:Showed no treatment-related mortality across all doses.
Observed hair loss in female rats treated with 500 mg/kg and 1000 mg/kg.
Found no urinalysis abnormalities at any dose.
Observed no significant hematology changes in the 250 mg/kg group.
Showed no serum biochemistry changes at 250 mg/kg.
Found no significant organ weight changes at 250 mg/kg.
Observed no exposure-related histopathology changes in organs other than the kidney.
Chemical Information
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CAS No. 7722-88-5
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Appearance Solid
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Molecular Weight 265.90
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Formula Na4P2O7
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Color White to off-white
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SMILES
[Na].O=P(O)(O)OP(=O)(O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 50 mg/mL (188.04 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (615 KB)
- English - EN (615 KB)
- Français - FR (615 KB)
- Deutsch - DE (615 KB)
- Norwegian - NO (615 KB)
- Español - ES (615 KB)
- Swedish - SV (615 KB)
- Italian - IT (615 KB)
- Korean - KR (615 KB)
- Portuguese - PT (615 KB)
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Handling Instructions (2659 KB)
References
[1]. Wang Q, et al. Tetrasodium pyrophosphate ameliorates oxidative damage to the TGase-catalyzed gelation of actomyosins. Food Chem. 2022;378:132128. [Content Brief]
[2]. Pedrazzi V, et al. Clinical evaluation of residual tetrasodium pyrophosphate released from two different anticalculus flosses. Braz Dent J. 2015;26(2):116-120. [Content Brief]
[3]. Hassanpour H, et al. Impact of sodium pyrophosphate and static magnetic field on Haematococcus pluvialis: enhancement of astaxanthin accumulation, PAL, and antioxidant enzyme activities. Physiol Mol Biol Plants. 2022 Jun;28(6):1207-1216. [Content Brief]
[4]. Seo DS, et al. Acute Oral or Dermal and Repeated Dose 90-Day Oral Toxicity of Tetrasodium Pyrophosphate in Spraque Dawley (SD) Rats. Environ Health Toxicol. 2011;26:e2011014. [Content Brief]
[5]. Abdelazim, M. H., et al., (2022). The effect of intra-nasal tetra sodium pyrophosphate on decreasing elevated nasal calcium and improving olfactory function post COVID-19: a randomized controlled trial. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 18(1), 67. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.7608 mL | 18.8041 mL | 37.6081 mL | 94.0203 mL |
| 5 mM | 0.7522 mL | 3.7608 mL | 7.5216 mL | 18.8041 mL | |
| 10 mM | 0.3761 mL | 1.8804 mL | 3.7608 mL | 9.4020 mL | |
| 15 mM | 0.2507 mL | 1.2536 mL | 2.5072 mL | 6.2680 mL | |
| 20 mM | 0.1880 mL | 0.9402 mL | 1.8804 mL | 4.7010 mL | |
| 25 mM | 0.1504 mL | 0.7522 mL | 1.5043 mL | 3.7608 mL | |
| 30 mM | 0.1254 mL | 0.6268 mL | 1.2536 mL | 3.1340 mL | |
| 40 mM | 0.0940 mL | 0.4701 mL | 0.9402 mL | 2.3505 mL | |
| 50 mM | 0.0752 mL | 0.3761 mL | 0.7522 mL | 1.8804 mL | |
| 60 mM | 0.0627 mL | 0.3134 mL | 0.6268 mL | 1.5670 mL | |
| 80 mM | 0.0470 mL | 0.2351 mL | 0.4701 mL | 1.1753 mL | |
| 100 mM | 0.0376 mL | 0.1880 mL | 0.3761 mL | 0.9402 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Tetrasodium pyrophosphate Related Classifications
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