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  3. Biochemical Assay Reagents OGT Glycosidase
  4. UDP-GalNAz disodium

UDP-GalNAz disodium  (Synonyms: UDP-N-azidoacetylgalactosamine disodium)

製品番号: HY-145934 純度: 99.89%
COA 取扱説明書 Technical Support

UDP-GalNAz (UDP-N-azidoacetylgalactosamine) disodium is the analogue of UDP-GalNAc disodium (HY-114365). UDP-GalNAc disodium is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor. UDP-GalNAz disodium is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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UDP-GalNAz disodium

UDP-GalNAz disodium 構造式

CAS 番号 : 653600-61-4

容量 価格（税別） 在庫状況 数量
5 mg $420 在庫あり
10 mg $660 在庫あり
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Based on 1 publication(s) in Google Scholar

Other Forms of UDP-GalNAz disodium:

UDP-GalNAz disodium 関連抗体

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製品説明

UDP-GalNAz (UDP-N-azidoacetylgalactosamine) disodium is the analogue of UDP-GalNAc disodium (HY-114365). UDP-GalNAc disodium is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor. UDP-GalNAz disodium is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups[1][2][3][4][5][6].

体外実験

UDP-GalNAz disodium can be used as a substrate for GalNAc-Ts, and be transferred by GalNAc-Ts to Ser, Thr, and Tyr residues of proteins to form O-GalNAc glycosylation[6].
UDP-GalNAz disodium can react with other chemical groups, such as bioorthogonal azide-alkyne cycloaddition reactions, to introduce chemical handles onto glycoproteins. UDP-GalNAz disodium can thereby be used for research of glycosylation proteins[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UDP-GalNAz disodium 関連抗体
分子量

692.33

分子式

C17H24N6Na2O17P2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(OP(O[C@@H]3[C@H](NC(CN=[N+]=[N-])=O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)(O[Na])=O)(O[Na])=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (144.44 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (144.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4444 mL 7.2220 mL 14.4440 mL
5 mM 0.2889 mL 1.4444 mL 2.8888 mL
10 mM 0.1444 mL 0.7222 mL 1.4444 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (3.61 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (3.61 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.89%

COA (255 KB) HNMR (304 KB) RP-HPLC (205 KB) LCMS (107 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.4444 mL 7.2220 mL 14.4440 mL 36.1099 mL
5 mM 0.2889 mL 1.4444 mL 2.8888 mL 7.2220 mL
10 mM 0.1444 mL 0.7222 mL 1.4444 mL 3.6110 mL
15 mM 0.0963 mL 0.4815 mL 0.9629 mL 2.4073 mL
20 mM 0.0722 mL 0.3611 mL 0.7222 mL 1.8055 mL
25 mM 0.0578 mL 0.2889 mL 0.5778 mL 1.4444 mL
30 mM 0.0481 mL 0.2407 mL 0.4815 mL 1.2037 mL
40 mM 0.0361 mL 0.1805 mL 0.3611 mL 0.9027 mL
50 mM 0.0289 mL 0.1444 mL 0.2889 mL 0.7222 mL
60 mM 0.0241 mL 0.1204 mL 0.2407 mL 0.6018 mL
80 mM 0.0181 mL 0.0903 mL 0.1805 mL 0.4514 mL
100 mM 0.0144 mL 0.0722 mL 0.1444 mL 0.3611 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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UDP-GalNAz disodium Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UDP-GalNAz disodium653600-61-4UDP-N-azidoacetylgalactosamine disodiumBiochemical Assay ReagentsOGTGlycosidaseO-linked N-acetylglucosaminyltransferaseO-GlcNAc transferaseUDP-GalNAc analoguenucleotide sugarInhibitorinhibitorinhibit

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製品名:
UDP-GalNAz disodium
製品番号:
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