UDP-GalNAz disodium (Synonyms: UDP-N-azidoacetylgalactosamine disodium)

Name: UDP-GalNAz disodium
Brand: MedChemExpress
SKU: HY-145934
Rating: 4.5 (1 reviews)

Art. -Nr.: HY-145934 Reinheit: 99.89%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

UDP-GalNAz (UDP-N-azidoacetylgalactosamine) disodium is the analogue of UDP-GalNAc disodium (HY-114365). UDP-GalNAc disodium is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor. UDP-GalNAz disodium is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

UDP-GalNAz disodium Chemische Struktur

CAS. Nr. : 653600-61-4

Größe	Verfügbarkeit	Menge
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Angebot einholen
100 mg	Angebot einholen

or Massenanfrage

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

This product is a controlled substance and not for sale in your territory.

Kundenbewertung

Based on 1 publication(s) in Google Scholar

Other Forms of UDP-GalNAz disodium:

UDP-GlcNAz disodium In-stock
UDP-GlcNAz Angebot einholen

1 Publications Citing Use of MCE UDP-GalNAz disodium

•Cell Chem Biol. 2025 Dec 8;32(12):1486-1502.e7.

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

In Vitro

UDP-GalNAz disodium can be used as a substrate for GalNAc-Ts, and be transferred by GalNAc-Ts to Ser, Thr, and Tyr residues of proteins to form O-GalNAc glycosylation^[6].
UDP-GalNAz disodium can react with other chemical groups, such as bioorthogonal azide-alkyne cycloaddition reactions, to introduce chemical handles onto glycoproteins. UDP-GalNAz disodium can thereby be used for research of glycosylation proteins^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

692.33

Formel

C₁₇H₂₄N₆Na₂O₁₇P₂

CAS. Nr.

653600-61-4

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(OP(O[C@@H]3[C@H](NC(CN=[N+]=[N-])=O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)(O[Na])=O)(O[Na])=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (144.44 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (144.44 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4444 mL	7.2220 mL	14.4440 mL
5 mM	0.2889 mL	1.4444 mL	2.8888 mL
10 mM	0.1444 mL	0.7222 mL	1.4444 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (3.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Reinheit & Dokumentation

Purity: 99.89%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (255 KB) HNMR (304 KB) RP-HPLC (205 KB) LCMS (107 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Hang HC, et al. Probing glycosyltransferase activities with the Staudinger ligation. J Am Chem Soc. 2004;126(1):6-7. [Content Brief]

[2]. Bourgeaux V, et al. Two-step enzymatic synthesis of UDP-N-acetylgalactosamine. Bioorg Med Chem Lett. 2005;15(24):5459-5462. [Content Brief]

[3]. Hang HC, et al. A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation. Proc Natl Acad Sci U S A. 2003;100(25):14846-14851. doi:10.1073/pnas.2335201100

[4]. Lo PW, et al. O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2. Proc Natl Acad Sci U S A. 2018;115(28):7302-7307. [Content Brief]

[5]. Vanessa Bourgeaux, et al. Two-step enzymatic synthesis of UDP-N-acetylgalactosamine. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5459-62. [Content Brief]

[6]. Choi J, et al., Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs. J Am Chem Soc. 2019 Aug 28;141(34):13442-13453. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	1.4444 mL	7.2220 mL	14.4440 mL	36.1099 mL
	5 mM	0.2889 mL	1.4444 mL	2.8888 mL	7.2220 mL
	10 mM	0.1444 mL	0.7222 mL	1.4444 mL	3.6110 mL
	15 mM	0.0963 mL	0.4815 mL	0.9629 mL	2.4073 mL
	20 mM	0.0722 mL	0.3611 mL	0.7222 mL	1.8055 mL
	25 mM	0.0578 mL	0.2889 mL	0.5778 mL	1.4444 mL
	30 mM	0.0481 mL	0.2407 mL	0.4815 mL	1.2037 mL
	40 mM	0.0361 mL	0.1805 mL	0.3611 mL	0.9027 mL
	50 mM	0.0289 mL	0.1444 mL	0.2889 mL	0.7222 mL
	60 mM	0.0241 mL	0.1204 mL	0.2407 mL	0.6018 mL
	80 mM	0.0181 mL	0.0903 mL	0.1805 mL	0.4514 mL
	100 mM	0.0144 mL	0.0722 mL	0.1444 mL	0.3611 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

UDP-GalNAz disodium Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UDP-GalNAz disodium653600-61-4UDP-N-azidoacetylgalactosamine disodiumBiochemical Assay ReagentsOGTGlycosidaseO-linked N-acetylglucosaminyltransferaseO-GlcNAc transferaseUDP-GalNAc analoguenucleotide sugarInhibitorinhibitorinhibit

Ihre kürzlich angesehenen Produkte:

Produktname

Requested Quantity *

Name des Antragstellers *

Anrede

E-Mail-Addresse *

Telefonnummer *

Department

Name der Organisation *

City

Bundesland

Country or Region *

Bemerkungen

Produktname

Lot #

Name des Antragstellers *

E-Mail-Addresse *

Telefonnummer

Department *

Name der Organisation *

Country or Region *

Bemerkungen

Name
Email *

	Sorry, but the email address you supplied was invalid.

UDP-GalNAz disodium (Synonyms: UDP-N-azidoacetylgalactosamine disodium)

Kundenbewertung

Other Forms of UDP-GalNAz disodium:

UDP-GalNAz disodium Related Antibodies

1 Publications Citing Use of MCE UDP-GalNAz disodium

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

UDP-GalNAz disodium Related Antibodies

Molaritätsrechner

Verdünnungsrechner

Complete Stock Solution Preparation Table

UDP-GalNAz disodium Related Classifications

Keywords:

Ihre kürzlich angesehenen Produkte:

Kundenbewertung

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report